4篇
您的检索式：作者名="Longhao Sun"
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| 1 | Preoperative serum alkaline phosphatase: a predictive factor for early hypocalcaemia following parathyroidectomy of primary hyperparathyroidism显示文摘 | Sun Longhao He Xianghui Liu Tong | 2014 | Chinese Medical Journal2014，，18： | 7 |
| 2 | MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma(PDAC) is considered to be the most lethal and aggressive malignancy with high mortality and poor prognosis. Their responses to current multimodal therapeutic regimens are limited. It is urgently needed to identify the molecular mechanism underlying pancreatic oncogenesis. Twelve core signaling cascades have been established critical in PDAC tumorigenesis by governing a wide variety of cellular processes. Micro RNAs(mi RNAs) are aberrantly expressed in different types of tumors and play pivotal roles as post-transcriptional regulators of gene expression. Here, we will describe how mi RNAs regulate different signaling pathways that contribute to pancreatic oncogenesis and progression. | Longhao Sun Corrine Ying Xuan Chua Weijun Tian Zhixiang Zhang Paul J.Chiao Wei Zhang | 2015 | Journal of Genetics and Genomics2015，42，10： | 3 |
| 3 | NAS4RRAM: neural network architecture search for inference on RRAM-based accelerators显示文摘The RRAM-based accelerators enable fast and energy-efficient inference for neural networks.However, there are some requirements to deploy neural networks on RRAM-based accelerators, which are not considered in existing neural networks.(1) Because the noise problem and analog-digital converters/digitalanalog converters(ADC/DAC) affect the prediction accuracy, they should be modeled in networks.(2) Because the weights are mapped to the RRAM cells, they should be quantized, and the number of weights is limited by the number of RRAM cells in the accelerator. These requirements motivate us to customize the hardware-friendly network for the RRAM-based accelerator. We take the idea of network architecture search(NAS) to design networks with high prediction accuracy that meet the requirements. We propose a framework called NAS4RRAM to search for the optimal network on the given RRAM-based accelerator. The experiments demonstrate that NAS4RRAM can apply to different RRAM-based accelerators with different scales. The performance of searched networks outperforms the manually designed ResNet. | Zhihang YUAN Jingze LIU Xingchen LI Longhao YAN Haoxiang CHEN Bingzhe WU Yuchao YANG Guangyu SUN | 2021 | Science China(Information Sciences)2021，64，6： | 0 |
| 4 | Efficacy and safety of subsequent radiotherapy in patients with advanced-stage hepatocellular carcinoma treated with immune checkpoint inhibitors显示文摘Background:The development of immunotherapy resistance is associated with a poor prognosis in patients diagnosed with hepatocellular carcinoma(HCC)who are undergoing treatment with immune checkpoint inhibitors(ICI).This study aimed to evaluate the efficacy and safety of subsequent radiotherapy(RT)for patients with advanced-stage HCC who had lesion enlargement or new lesions(NLs)during ICI therapy.Methods:This retrospective observational study enrolled 36 patients with advanced-stage HCC who underwent subsequent RT for lesion enlargement or NLs during ICI therapy from two centers.The primary endpoints were progression-free survival(PFS)and overall survival(OS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),1-and 2-year local control(LC)rates,in-field PFS(IFPFS),out-field PFS(OFPFS),and safety.Results:The median follow-up time was 15.3 months.The median PFS was 7.4 months[95%confidence interval(CI):3.1-11.7 months],and the median OS was 18.8 months(95%CI:17.1-20.5 months).ORR and DCR were 38.9%and 72.2%,respectively.In addition,the median IFPFS was 17.8 months(95%CI:11.5-24.2 months),median OFPFS was 7.9 months(95%CI:3.4-12.5 months),and estimated 1-and 2-year LC rates were 67.1%and 31.9%,respectively.The most common treatment-related adverse events(all grades)were diarrhea(33.3%),rash(30.6%),and malaise(27.8%);a total of 14(38.9%)patients developed grade 3-4 AEs.Conclusions:Subsequent RT showed reliable antitumor effects and an acceptable safety profile in patients with advanced-stage HCC who had unsatisfactory response to ICI therapy;therefore,it could serve as an optional salvage strategy. | Cong Ning Jun Jia Xinmu Zhang Jing Sun Yunchao Wang Jingnan Xue Longhao Zhang Xiaorong Hou Xiaobo Yang Xinting Sang Xuezhang Duan Haitao Zhao | 2023 | Hepatobiliary Surgery and Nutrition2023，12，6： | 0 |
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