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| 1 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | Photoinhibition of Photosynthesis in Nature显示文摘 | S P Long S Humphries P G Falkowski | 1994 | Annual Review of Plant Physiology and Plant Molecular Biology1994，，： | 2 |
| 4 | The potential for resistance to Botrytis cinerea by kiwifruit显示文摘 | Wurms K V Long P G Sharrock K R | 1999 | Crop Protection1999，18，： | 1 |
| 5 | The effect of 03 fumigation during leaf development on photosynthesis of wheat and pea: An invivo analysis 显示文摘 | Farage P K Long S P | 1999 | Photosynthesis Research1999，59，： | 1 |
| 6 | Large-scale fabrication of single-Crystalline Mn3O4 nanowires via vapor phase growth显示文摘 | D P Yu Y Long | 2005 | Journal of Crystal Growth2005，279，： | 1 |
| 7 | Measurement of leaf and canopy photosynthetic C02 exchange in the field显示文摘 | Farageand P K Garcia R L | 1996 | Journal of Experimental Botany1996，47，304： | 1 |
| 8 | What have we learned from 15 years of free-air CO2 enrichment(FACE)?A meta-analytic review of the responses of photosynthesis,canopy properties and plant production to rising CO2显示文摘 | AINSWORTH E A LONG S P | 2005 | New Phytologist2005，165，2： | 1 |
| 9 | The effect of early to mid-gestational nutrient restrietion on female offspring fertility and hypothalamic-pituitary-adrenal axis response to stress 显示文摘 | Long N M Nijland M J Nathanielsz P W | 2010 | J Anim Sci2010，88，6： | 1 |
| 10 | Confronting conceptual confusion and conflict in knowledge management 显示文摘 | De Long D Seemann P | 2000 | Organizational Dynamics2000，29，1： | 1 |
| 11 | Effects of rising CO2concentration on expression of photosynthrtic protein显示文摘 | Webber A N Nie G Y Long S P | 1994 | Photosynth Res1994，39，： | 1 |
| 12 | Facts & figures chemical R & D显示文摘 | Brennan M B Long J R Zurer P R | 1997 | C & EN1997，75，35： | 1 |
| 13 | Cost-effective mass fabrication of multilevel differactive optical elements by a set of a single exposure with a Gray-scale mask on high-energy beam-sensitive glass显示文摘 | Daschner W Long P | 1997 | Appl Opt1997，36，： | 1 |
| 14 | Multiclass linear dimension reduction by weighted Pairwise Fisher criteria显示文摘 | Long M Duin R P W Haeb- Umbach R | 2001 | IEEE Transactions on Pattern Analysis and Machine Intelligence2001，23，7： | 1 |
| 15 | Application of the quadrilateral area coordinate method: A new element for Mindlin -Reissner plate 显示文摘 | Cen S Long Y Q Yao Z H Chiew S P | 2006 | International Journal for Numerical Methods in Engineering2006，66，1： | 1 |
| 16 | A dynamic disk spin down technique for mobile computing显示文摘 | David P Helmbold E Long D D Sherrod B | 1996 | Computing and Net- working1996，，： | 1 |
| 17 | Characterization of Hydrophobic Hypercrosslinked Polymer as an Adsorbent for Removal of Chlorinated Volatile Organic Compounds显示文摘 | Long C Liu P Li Y | 2011 | Environmental Science and Technology2011，45，10： | 1 |
| 18 | Can improved photosynthesis increase crop yields? 显示文摘 | Long S P Zhu X G Naidu S L | 2006 | Plant Cell Environ2006，29，： | 1 |
| 19 | Nuclear Magnetic Resonance studies of water mobility in bread during storage 显示文摘 | Chen P L Long Z Ruan R | 1997 | LWT- Food Science and Technology1997，30，2： | 1 |
| 20 | Improving photosynthetic effi ciency for greater yield 显示文摘 | Zhu X G Long S P Ort D R | 2010 | Annual Review of Plant Biolo gy2010，61，1： | 1 |
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