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| 1 | Startup and operation of anaerobic EGSB reactor treating palm oil mill effluent显示文摘A bench-scale expanded granular sludge bed (EGSB) reactor was applied to the treatment of palm oil mill effuent (POME). The reactor had been operated continuously at 35°C for 514 d, with organic loading rate (OLR) increased from 1.45 to 17.5 kg COD/(m3·d). The results showed that the EGSB reactor had good performance in terms of COD removal on the one hand, high COD removal of 91% was obtained at two days’ of hydraulic retention time (HRT), and the highest OLR of 17.5 kg COD/(m3·d). On the other hand, only 46% COD in raw POME was transformed into biogas in which the methane content was about 70% (V/V). A 30-d intermittent experiment indicated that the maximum transformation potential of organic matter in raw POME into methane was 56%. Volatile fatty acid (VFA) accumulation was observed in the later operation stage, and this was settled by supplementing trace metal elements. On the whole, the system exhibited good stability in terms of acidity and alkalinity. Finally, the operational problems inherent in the laboratory scale experiment and the corresponding countermeasures were also discussed. | ZHANG Yejian YAN Li CHI Lina LONG Xiuhua MEI Zhijian ZHANG Zhenjia | 2008 | Journal of Environmental Sciences2008，20，6： | 18 |
| 2 | Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation显示文摘瞄准: 调查在鼻咽的癌(NPC ) 上位于 celecoxib 的 anticancer 效果下面的机制。 | Dong-bo LIU Guang-yuan HU Guo-xian LONG Hong QIU Qi MEI Guo-qing HU | 2012 | Acta Pharmacologica Sinica2012，33，5： | 16 |
| 3 | Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients显示文摘BACKGROUND The methylated septin 9(mSEPT9) assay was the first blood-based test approved by the United States Food and Drug Administration as a colorectal screening test.However, the diagnostic and prognostic role of preoperative mSEPT9 for colorectal cancer(CRC) in Chinese patients is still unknown.AIM To improve the understanding of diagnostic and prognostic factors, serum m SEPT9 was detected in Chinese CRC patients.METHODS A retrospective analysis of 354 cases, of which 300 had CRC and 54 were normal,was performed in China. Patients' characteristics, treatments, and laboratory data, including age, the date of surgery, Union for International Cancer Control(UICC) stages, distant metastasis(M), and so on, were collected. Methylation levels of SEPT9 were quantified by quantitative, methylation-specific polymerase chain reaction before surgery. In addition, the effects of mSEPT9 on the occurrence and prognosis of 330 CRC cases from The Cancer Genome Atlas(TCGA) database were evaluated using bioinformatics analyses. Potential prognostic factors for overall survival(OS) and progression-free survival(PFS)were evaluated by Kaplan-Meier univariate analysis.RESULTSIn Chinese CRC patients, positive mSEPT9 was strongly associated with advanced UICC stages, deeper invasion by the primary tumor, and more distant metastasis. Methylation levels of SEPT9 were stage-dependent and showed a stepwise increase in UICC stages(I–IV), primary tumor categories(T1–T4),regional node categories(N0–N2), and distant metastasis categories(M0–M1).The patients with positive mSEPT9 showed a tendency toward lower PFS. After analyzing TCGA clinical data, the high mSEPT9 group was found to be obviously correlated only with more distant metastasis. The patients with high mSEPT9 levels showed a tendency toward lower OS. Besides, nine meaningful mSEPT9 sites were found to provide guidance for the follow-up studies.CONCLUSION MSEPT9 analysis may add valuable information to current tumor staging. Serum m SEPT9 in Chinese CRC patients appears to offer promising novel prognostic markers and might be considered for monitoring CRC recurrence. | Xue Yang Zhi-Jie Xu Xi Chen Shuang-Shuang Zeng Long Qian Jie Wei Mei Peng Xiang Wang Wan-Li Liu Hong-Ying Ma Zhi-Cheng Gong Yuan-Liang Yan | 2019 | World Journal of Gastroenterology2019，25，17： | 16 |
| 4 | Ginsenoside-Rg_6, a Novel Triterpenoid Saponin from the Stem-Leaves of Panax ginseng C. A. Mey.显示文摘A novel dammarane-type triterpene oligoglycoside, named ginsenoside-Rg6 3, was isolated from the stem-leaves of Panax ginseng C. A. Mey., together with two known ones, 20(S)-ginsenoside-Rg2 1 and 20(R)-ginsenoside-Rg2 2. On the basis of chemical and physicochemical evidence , the structure of ginsenoside-Rg6 have been elucidated as 6-O-(-L-rhamnosyl-(1?2)-(-D-glucopyranosyl-dammarane-(E)-20(22), 24-diene-3(, 6(, 12(-triol. | Xiu Wei YANG, Long Yun LI, Jian Ming TIAN, Zhi Wei ZHANG, Jin Mei YE, Wei Fang Gu (National Research Laboratory of Natural & Biomimetic Drugs, Peking University, Beijing 100083) (Academy of Chinese Traditional Medicine and Materia Medica of Jilin Provinc | 2000 | Chinese Chemical Letters2000，11，10： | 12 |
| 5 | MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803显示文摘作为基因表示的 post-transcriptional 管理者的一个家庭, microRNAs (miRNAs ) 控制包括房间区别,增长和 apoptosis 的生物进程的一个宽数组,和 miRNAs 的 dysregulation 是癌症的一个特点。这里,我们发现 microRNA-191 (miR-191 ) 在在人的胃的腺癌房间线 MGC803 和人的胃的癌症纸巾的高表示的水平。-2,5-diphenyltetrazolium 溴化物和殖民地形成试金显示出的 3-(4,5-dimethylthiazol-2-yl ) 的结果那 miR-191 能支持房间生长并且压制 MGC803 房间的 apoptosis。N-deacetylase/N-sulfotransferase 1 (NDST1 ) 被证实是提高的绿色边的 miR-191 的直接目标基因荧光灯蛋白质记者实验。NDST1 的 mRNA 和蛋白质层次相反地在 MGC803 房间与 miR-191 被相关,建议由 miR-191 的 NDST1 的否定规定。而且, NDST1 起了一个禁止的作用并且能压制 MGC803 房间增长。我们的调查结果建议 miR-191 能在 MGC803 房间充当 oncogene,并且细胞的功能部分由于它 NDST1 的否定规定。 | Xuejun Shi Shicang SU Jian Long Bing Mei Yajun Chen | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 12 |
| 6 | Specific targeting of nasopharyngeal carcinoma cell line CNE1 by C225-conjugated ultrasmall superparamagnetic iron oxide particles with magnetic resonance imaging显示文摘临床的目标体积(CTV ) 的一个精确定义为在鼻咽的癌(NPC ) 的放射疗法的应用程序是必要的处理。指向对比代理人(C225-USPIO ) 的新奇表皮的生长因素受体(EGFR ) 被结合 ultrasmall superparamagnetic 设计有 cetuximab (C225 ) 的氧化铁(USPIO ) nanoparticles, non-invasively 定义肿瘤的 CTV。到 NPC 房间线 CNE1 的 C225-USPIO 的 immunobinding 活动被流动 cytometry 和 immunofluorescence 证实。在 CNE1 房间的 C225-USPIO 的时间依赖者累积用普鲁士的蓝染色被评估。指向的成为主观和 C225-USPIO 的 subcellular 本地化被传播电子显微镜证实。结果显示了明确地在 CNE1 房间的表面上绑在 EGFR 的那 C225-USPIO 并且被收起进房间。由 CNE1 房间的 C225-USPIO 的举起与时间显著地增加了,当时与人的 IgG-USPIO 相比。另外, 4.7 T 磁性的回声成像(MRI ) 随着时间的过去表明 C225-USPIO 有一个能力在 CNE1 房间积累,与在 MRI T2 加权的信号紧张的结果的显著减少。这些调查结果当一个 MRI 对比代理人和罐头被采用 non-invasively 与 EGFR overexpression 检测早阶段的 NPC,暗示 C225-USPIO 有潜力。这为与混合物在 vivo 实验开始提供足够的理论基础。 | Dongbo Liu Chunli Chen Guangyuan Hu Qi Mei Hong Qiu Guoxian Long Guoqing Hu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 10 |
| 7 | Xa7, a new executor R gene that confers durable and broad-spectrum resistance to bacterial blight disease in rice显示文摘Bacterial blight(BB)is a globally devastating rice disease caused by Xanthomonas oryzae pv.oryzae(Xoo).The use of disease resistance(R)genes in rice breeding is an effective and economical strategy for the control of this disease.Nevertheless,a majority of R genes lack durable resistance for long-term use under global warming conditions.Here,we report the isolation of a novel executor R gene,Xa7,that confers extremely durable,broad-spectrum,and heat-tolerant resistance to Xoo.The expression of Xa7 was induced by incompatible Xoo strains that secreted the transcription activator-like effector(TALE)AvrXa7 or PthXo3,which recognized effector binding elements(EBEs)in the Xa7 promoter.Furthermore,Xa7 induction was faster and stronger under high temperatures.Overexpression of Xa7 or co-transformation of Xa7 with avrXa7 triggered a hypersensitive response in plants.Constitutive expression of Xa7 activated a defense response in the absence of Xoo but inhibited the growth of transgenic rice plants.In addition,analysis of over 3000 rice varieties showed that the Xa7 locuswas found primarily in the indica and aus subgroups.A variation consisting of an 11-bp insertion and a base substitution(G to T)was found in EBEAvrXa7 in the tested varieties,resulting in a loss of Xa7 BB resistance.Through a decade of effort,we have identified an important BB resistance gene and characterized its distinctive interaction with Xoo strains;these findings will greatly facilitate research on the molecular mechanism of Xa7-mediated resistance and promote the use of this valuable gene in breeding. | Xifeng Chen Pengcheng Liu Le Mei Xiaoling He Long Chen Hui Liu Shurong Shen Zhandong Ji Xixi Zheng Yuchen Zhang Zhenyu Gao Dali Zeng Qian Qian Bojun Ma | 2021 | Plant Communications2021，2，3： | 9 |
| 8 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 9 | Seismogenic Structure around the Epicenter of the May 12,2008 Wenchuan Earthquake from Micro-seismic Tomography显示文摘一个三维的本地规模的 P 速度模型在下面到 25 km,在主要吃惊震中区域附近的深度用从 5856 余震的地震光线由一个最新部署的暂时的地震网络记录了的 83821 event-to-receiver 被构造。棋盘测试证明我们的 tomographic 模型有 ∼2 km 的侧面、垂直的分辨率。高分辨率的 P 速度模型在 seismogenic 层揭示了有趣的结构:(1 ) Guanxian-Anxian 差错, Yingxiu-Beichuan 差错和 Longmen 掸人差错地区的 Wenchuan-Maoxian 差错好由突然地上面的外壳的速度变化描出;(2 ) Pengguan 山岳比它的包围区域有通常更高的速度,并且可以延长在下面到从表面的至少 ∼10 km;(3 ) 在 Wenchuan-Maoxian 差错下面的一个突然地侧面的速度变化可以显示 Pengguan 山岳的西方的边界或 Wenchuan-Maoxian 差错是垂直的,并且 Wenchuan 地震的低亚硫酸钠中心可能在蘸 Yingxiu-Beichuan 和 Guanxian-Anxian 差错,和垂直 Wenchuan-Maoxian 差错的 NW 的连词点定位;(4 ) 沿着 Yingxiu-Beichuan 差错的附近被很低的速度和低 seismicity 在浅深度描绘,可能由于孔和破裂的高内容;(5 ) 二块低速度的异例分别地与 ∼5 km 与 ∼7 km 偏移量在挂的墙和 Guanxian-Anxian 差错的脚墙中被想象垂直部件。 | AN Meijian FENG Mei DONG Shuwen LONG Changxing ZHAO Yue YANG Nong ZHAO Wenjin ZHANG Jizhong | 2009 | Acta Geologica Sinica(English Edition)2009，83，4： | 7 |
| 10 | Epidermal growth factor receptor-targeted ultra-small superparamagnetic iron oxide particles for magnetic resonance molecular imaging of lung cancer cells in vitro显示文摘 | CHEN Chun-li HU Guang-yuan MEI Qi QIU Hong LONG Guo-xian HU Guo-qing | 2012 | Chinese Medical Journal2012，，13： | 7 |
| 11 | Determination of Partial Molar Volumes of EPA and DHA Ethyl Esters in Supercritical Carbon Dioxide显示文摘The use of supercritical-fluid chromatography for determining partial molar volumes of ethyl esters of cis-5,8,11,14,17-eicosapentaenoic acid (EPA) and cis -4,7,10,13,16,19- docosa-hexaenoic acid (DHA) in supercritical carbon dioxide is presented and discussed. Partial molar volumes of EPA and DHA esters are obtained from the variation of the retention properties with the density of mobile phase at 313.15 K, 323.15 K, 333.15 K and in the pressure range from 9 MPa to 21 MPa. | Mei HUANG, Xian Da WANG, Ren Tian XIONG, Ping Dong WU, Qi Long REN* National Laboratory of Secondary Resources Chemical Engineering, Zhejiang University, Hangzhou 310027 | 2002 | Chinese Chemical Letters2002，13，1： | 6 |
| 12 | Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain 13-amyloid through PPARy activation显示文摘 | Li-ping LIU Tian-hua YAN Li-ying JIANG Wei HU Meng HU Chao WANG Qian ZHANG Yan LONG Jiang-qing WANG Yong-qi LI Mei HU Hao HONG | 2013 | Acta Pharmacologica Sinica2013，34，4： | 6 |
| 13 | Seasonal changes of organic matter origins and anammox activity in the Changjiang Estuary deduced from multi-biomarkers in suspended particulates显示文摘Human activity-induced eutrophication and harmful algal blooms are main causes of the expansion of the hypoxic zone in the Changjiang Estuary. Among the many changes in biogeochemical processes, anaerobic ammonium oxidation(anammox) is proposed to play an important role in the nitrogen cycle in hypoxic areas. Ladderane lipids have been used as biomarkers to indicate anammox activity in ecosystems, but the origins of anammox bacteria and ladderanes in suspended particulates are still unclear. In this study, we report the results of a suite of biomarker analyses of suspended particulates across a salinity gradient of the Changjiang Estuary in both the spring and summer to evaluate the origins of the ladderanes and their potential as proxies for anammox activity and hypoxia. The spatio-temporal variations in terrestrial biomarkers(n-alkanes and n-alkanols), marine biomarkers(brassicasterol and dinosterol), and the Terrestrial and Marine Biomarker Ratio and Branched and Isoprenoid Tetraether indices reveal that marine organic matter was dominant in the particulates in both the spring(55%) and summer(86%) seasons. Correlations with both marine and terrestrial biomarkers suggest that ladderanes were mainly produced in the water column, and therefore that ladderane concentrations in suspended particulates in the Changjiang Estuary mainly reflect anammox activity in the water column, although changes in anammox bacterial assemblages may also have played a role in ladderane concentrations. Overall, ladderane results suggest that anammox activity was widespread in the Changjiang Estuary; but higher ladderane concentrations in the summer(especially in the upwelling zone) were correlated with lower dissolved oxygen concentrations, which suggest that they are useful proxies for hypoxia. | HU Jing Wen ZHANG Hai Long LI Li WANG Yao Yao ZHAO Mei Xun | 2016 | Science China Earth Sciences2016，59，7： | 5 |
| 14 | The Research on Optimization of the Multiphase Flow Field of Biogas Plant by Using CFD Software显示文摘 | Ruyi Huang Yan Long Tao Luo Zili Mei Jun Wang Enshen Long | 2014 | Journal of Energy and Power Engineering2014，8，6： | 5 |
| 15 | Specific targeting of angiogenesis in lung cancer with RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a 4.7T magnetic resonance scanner显示文摘 | LIU Can LIU Dong-bo LONG Guo-xian WANG Jun-feng MEI Qi HU Guang-yuan QIU Hong HU Guo-qing | 2013 | Chinese Medical Journal2013，，12： | 5 |
| 16 | Dynamic blood single-cell immune responses in patients with COVID-19显示文摘The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency.However,the virus'pathogenesis remains unclear,and there is no cure for the disease.We investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell resolution.We obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic studies.In addition,we used three control samples.We found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical condition.The type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions improved.Consistent with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 controls.The concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of COVID-19.TCR and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 antigens.Our study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic potentials in treating COVID-19. | Lulin Huang Yi Shi Bo Gong Li Jiang Zhixin Zhang Xiaoqi Liu Jialiang Yang Yongquan He Zhilin Jiang Ling Zhong Juan Tang Chunfang You Qi Jiang Bo Long Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Shuqiang Wang Xingxiang Yang Zhenglin Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 4 |
| 17 | A switched system approach to stabilization of networked control systems显示文摘A switched system approach is proposed to model networked control systems (NCSs) with communication constraints. This enables us to apply the rich theory of switched systems to analyzing such NCSs. Sufficient conditions are presented on the stabilization of NCSs. Stabilizing state/output feedback controllers can be constructed by using the feasible solutions of some linear matrix inequalities (LMIs). The merit of our proposed approach is that the behavior of the NCSs can be studied by considering switched system without augmenting the system. A simulation example is worked out to illustrate the effectiveness of the proposed approach. | Mei YU Long WANG Guangming XIE | 2006 | 控制理论与应用(英文版)2006，4，1： | 4 |
| 18 | β-hydroxy-β-methylbutyrate Improves Chronic Renal Failure-Induced Sarcopenia in SD Rats by Regulating Autophagy显示文摘Background Chronic renal failure-induced sarcopenia(CRF-S)seriously affects public health by increasing morbidity and mortality.This study evaluated the therapeutic effects ofβ-hydroxy-β-methylbutyrate acid(HMB)and the underlying mechanism in an adenine-induced CRF-S rat model.Methods Sprague Dawley rats were divided into control,model(CRF-S),and HMB treatment(CRF-S+HMB)groups.The rats in the CRF-S group received 250 mg/kg/d adenine by oral gavage every day for 14 days,followed by administration every other day until the 28th day.In the CRF-S+HMB group,each rat was given 320 mg/kg/d HMB by oral gavage starting from 7 days prior to adenine treatment,and this treatment was maintained for a total of 35 days.The body weight,right anterior tibial muscle weight,blood serum parameters,gastrocnemius muscle and renal tissue histology,and expression of autophagy-related transcripts and proteins were evaluated.Results A rat model of CRF-S was successfully established via adenine gavage,as indicated by reduced body weight and muscle weights,and markers of sarcopenia.There were increased mRNA levels of LC3B,Beclin1,Ulk1,Atg5,Atg7,Atg13 and vps-34,and increased protein expression levels of LC3B and P62.In the rats with HMB intervention,the body weight,right anterior tibial weight and gastrocnemius muscle histology were not significantly different from those in the control group,and the expression levels of autophagy-related proteins(LC3B and P62)were consistent with those in the control group.Conclusion We successfully established a rat model of CRF-S using adenine administered via oral gavage,and observed that HMB treatment prevented CRF-S. | Zun Yue Zhang Liu Qing Yang Ya Nan Yang Yun Lin Wang Long Mei Zhang Kun Hua Wang Min Weng | 2021 | Journal of Nutritional Oncology2021，6，4： | 4 |
| 19 | Effect of montmorillonite on kinetics of polyurethane preparation reaction显示文摘prepolymerization 和 polyurethane/montmorillonite 的治好的反应动力学分别地与端基分析和 FTIR 被学习了。prepolymerization 和治好的反应跟随了第二顺序动力学,这被发现。但是在 montmorillonite 以后从 42.7 kJ/mol 增加到 56.5 kJ/mol 的 prepolymerization 的激活精力在治好反应的反应系统,和激活精力被增加从 64.4 kJ/mol 减少了到 17.5 kJ/mol。 | You Cao Yu Jiang Shu Lu Zhao Xiao Jun Cai Mei Long Hu Bing Liao | 2008 | Chinese Chemical Letters2008，19，1： | 4 |
| 20 | Coagulopathy in a subtype of choledochal cyst and management strategy显示文摘AIM:To evaluated our management algorithm of the coagulopathy.We evaluated our management algorithm of the coagulopathy.METHODS:Between October 2001 and January 2013,160 CDC children with coagulopathy(fibrinogen,FIB<2 g/L)were recruited.FIB≥1 g/L is generally required for safe elective surgery.We used FIB level as an indicator when:(1)patients with FIB levels between1-2 g/L underwent one-stage definitive operation;and(2)patients with FIB<1 g/L underwent 3 d of medical treatment.Thereafter,those with FIB≥1 g/L underwent one-stage definitive operation whereas those with FIB<1 g/L underwent external biliary drainage to allow liver function improvement.Those patients with liver function improvements underwent definitive operation after 7 d of drainage.RESULTS:After preoperative optimization,92.5%of CDC children with coagulopathy underwent successful one-stage definitive operation.The remaining 7.5%of CDC children required initial external bile drainage,and underwent definitive operation 11 d after the admission.The mean operative time and postoperative recovery duration were comparable to those with normal coagulations.The median follow-up period was 57 mo.No blood transfusion or other postoperative complications were encountered.CONCLUSION:Following our management protocol,the majority of CDC children with coagulopathy can be managed with one-stage definitive operation. | Mei Diao Long Li Wei Cheng | 2014 | World Journal of Gastroenterology2014，20，30： | 4 |
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