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| 1 | 2型糖尿病合并肢体部分性脂肪萎缩:一种新的脂肪萎缩表型显示文摘脂肪萎缩在糖尿病患者中并不罕见,2013年8期Diabetes Care刊登了Stricklan等的《2型糖尿病合并肢体部分性脂肪萎缩》一文,该文介绍了一种新的脂肪萎缩表型。来自NIH的Rother与Brown对该文进行了文献复习和评论。鉴于目前我国和全球T2DM患病者迅猛增加,而脂肪萎缩也是糖尿病合并症之一,为了引起临床医师对本合并症的重视,避免误漏诊,编辑部特将此二文介绍给本刊读者以供参考。 | 钱荣立 Strickland LR Guo F Lok K | 2015 | 中国糖尿病杂志2015，23，3： | 5 |
| 2 | 肝内胆管细胞癌和转移性胰腺导管腺癌的免疫组化鉴别显示文摘在肝脏活检标本中,原发性肝内胆管细胞癌(ICC)和转移性胰腺导管腺癌(PDA)组织学上难以区分,但二者的鉴别具有重要的临床意义。本组实验对41例ICCs和60例PDAs分别进行SLOOP、pVHL、IMP3、肿瘤抑制基因蛋白maspin、MUC5AC及CKl7蛋白的免疫表型评估,以了解这些标志物在两种疾病鉴别诊断中的价值。结果显示:29例(71%)ICCs表达pVHL,PDAs中仅3例(5%)出现pVHL表达。S100P、MUC5AC和CKl7在PDAs中阳性率较高,分别为57例(95%)、40例(67%)和36例(60%),ICCs中S100P、MUC5AC和CK17分别为11例(27%)、5例(12%)及5例(12%)表达。IMP3在ICCs和PDAs中阳性率均为90%。60例(100%)PDA和30例(73%)ICC患者存在maspin的阳性表达。作者对上述标志物表达情况进行归纳后发现,当免疫组化染色结果呈SLOOP-/pVHL+/MUC5AC-/CK17-时提示ICC,呈SLOOP+/pVHL-/MUC5AC+/CK17+和S100P+/pVHL-/MUC5AC-/CK17+时则提示PDA。据此可有效将ICC和PDA鉴别开来。 | Lok T Chen L Lin F 王慧 余英豪 | 2014 | 临床与实验病理学杂志2014，30，10： | 3 |
| 3 | Antiviral drug-resistant HBV: standardization of nomenclature and assays and recommendations for management显示文摘 | Lok AS Zoulim F Locarnini S | 2007 | Hepatology2007，46，1： | 1 |
| 4 | Provision of continuous VCR functions in interactive broadcast VoD systems 显示文摘 | POON W F LOK T FENG J | 2005 | IEEE Transition Broadcasting2005，51，4： | 1 |
| 5 | Activation of autophagy of aggregation-prone ubiquitinated proteins by timosaponin A-Ⅲ显示文摘 | Lok CN Sy LK Liu F | 2011 | J Biol Chem2011，286，31： | 1 |
| 6 | Hepatitis B virus variants显示文摘 | Chotiyaputta W Lok A S F | 2009 | Nat Rev Gastrol Hepatol2009，6，： | 1 |
| 7 | Antiviral drug-resistant HBV: standardization of nomenclature and assays and recommendations for management显示文摘 | Lok AS Zoulim F Locarnini S | 2007 | Hepatology2007，46，1： | 1 |
| 8 | Synthesis,processing and export of cytoplasmic endo-β-1, 4-xylanase from barley aleurone during germination 显示文摘 | Caspers M P M Lok F Sinjorgo K M C | 2001 | Plant J2001，26，2： | 1 |
| 9 | Isolation and characterization of the gene encoding the starch debranching enzyme limit dextrinase from germinating barley显示文摘 | Kristensen M Lok F Planchot V | 1999 | Biochimica et Biophysica Acta1999，1431，： | 1 |
| 10 | Antiviral Drug-Resistant HBV: Standardization of Nomenclature and Assays and Recommendations for Management显示文摘 | Lok AS Zoulim F Locarnini S | 2007 | Hepatology2007，46，： | 1 |
| 11 | Antiviral drug-resistant HBV: Standardization of nomendature and assays and recommenda tions for management 显示文摘 | Lok AS Zoulim F Locarnini S | 2007 | Hepatdogy2007，46，1： | 1 |
| 12 | Antiviral drug-resistant HBV:standardization of nomenclature and assays and recommendations for management显示文摘 | Lok AS Zoulim F Locarnini S | 2007 | Hepatology2007，46，1： | 1 |
| 13 | Dose-finding Study for the Use of Long-acting Gonadotrophin-releasing Hormone Analoges Prior to Ovarian Stimulation for IVF显示文摘 | Yim S F Lok I H Cheng L P | 2001 | Human Reprod2001，16，3： | 1 |
| 14 | Antiviral drugresistent HBV: Standardization of nomenclature and assays and recommendations for management 显示文摘 | Lok A S Zoulim F Locarnini S | 2007 | Hepatology2007，46，1： | 1 |
| 15 | Surgical management of tubal disease and infertility显示文摘 | Lok F Li TC | 2002 | Cur Obstetr Gynaeco12002，35，12： | 1 |
| 16 | Synthesis,processing and export of cytoplasmic endo-β-1,4-xylanase from barley aleurone during germination显示文摘 | Caspers M P M Lok F Sinjorgo K M C | 2001 | Plant J2001，26，2： | 1 |
| 17 | IL28B genetic variants and gender are associated with spontaneous clearance of hepatitis C virus infection 显示文摘 | Rao HY Sun DG Jiang D Yang RF Guo F Wang JH Liu F Zhang HY Zhang HH Du SC Jin Q Qin H Lok AS Wei L | 2012 | J Viral Hepat2012，19，3： | 1 |
| 18 | Meta-analysis of average and vari- ability of time to extubation comparing isoflurane with desflurane or isoflurane with sevoflurane显示文摘 | Agoliati A Dexter F Lok J | 2010 | Anesth Analg2010，110，5： | 1 |
| 19 | Antiviral drug -resistant HBV: standardization of nomenclature and assays and recommendations for management显示文摘 | Lok AS Zoulim F Locarnini S | 2007 | Hepatology2007，46，1： | 1 |
| 20 | Pricing games for distributed cooperative transmission显示文摘 | Ng C Y Lok T M and Wong T F | 2010 | IEEE Transactions on Vehicular Technology2010，59，7： | 1 |
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