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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Prevention of recurrent hepatitis B infection after liver transplantation显示文摘BACKGROUND:Recurrence of hepatitis B virus(HBV) infection after liver transplantation can lead to graft loss and a reduction in long-term survival.The purpose of this review is to summarize the current therapeutic options for preventing HBV recurrence in liver transplant recipients.DATA SOURCES:Up to January 2013,studies that were published in MEDLINE and EMBASE on prevention of HBV recurrence after liver transplantation were reviewed.RESULTS:There have been remarkable advancements in the past two decades on the prevention of HBV recurrence after liver transplantation,from the discovery of hepatitis B immune globulin(HBIG) and lamivudine monotherapy to the combination therapy using HBIG and lamivudine.With the development of newer and stronger antiviral agents,the need for life-long HBIG is doubtful.With their low resistance profile,oral antiviral prophylaxis using these new agents alone is sufficient and is associated with excellent outcome.CONCLUSIONS:Restoration of host HBV immunity with adoptive immunity transfer and vaccination may represent the ultimate strategy to withdraw prophylactic treatment and to achieve a drug free regimen against HBV recurrence after liver transplantation. | Tiffany CL Wong James YY Fung Chung Mau Lo | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 5 |
| 3 | Pre-ischemia electro-acupuncture potentiates the expression of Bcl-2 and transforming growth factor-beta 1 in rat brains显示文摘The expression of the anti-apoptotic molecules Bcl-2 and transforming growth factor-beta 1 is known to confer protective effects on the cerebral ischemia-reperfusion injury.The current study investigated the expression levels of Bcl-2 and transforming growth factor-beta 1 in response to multiple pre-ischemia electro-acupuncture at acupoints Zusanli(ST36)and Fengchi(GB20) stimulation.Rats were divided into five groups:uninjured,control,non-acupoint,GB20 and ST36. Rats in the non-acupoint,GB20 and ST36 groups received 30 minutes(3 times or 18 times)of electro-acupuncture stimulation before experimental cerebral ischemia was induced.Bcl-2 and transforming growth factor-beta 1 were found to be significantly increased in the ST36 groups with either 3 or 18 electro-acupuncture treatments(P<0.05).The production was higher with 18 electro-acupuncture treatments in the ST36 groups(P<0.05).In the GB20 groups,significant increase was only observed in transforming growth factor-beta 1 with 18 electro-acupuncture treatments(P<0.05).No significant elevation of the level of transforming growth factor-beta 1 was observed in the non-acupoint groups.However,the production of Bcl-2 increased with 18 treatments in the non-acupoint groups(P<0.05).The data suggest that multiple pre-ischemia electro-acupuncture at ST36 was effective in conferring neuroprotective effect on the brain by means of upregulation of Bcl-2 and transforming growth factor-beta 1 and the effect was increase with the number of treatment. | Ka Keung Yip Samuel CL Lo Kwok-fai So Dora MY Poon Mason CP Leung | 2012 | Neural Regeneration Research2012，7，24： | 3 |
| 4 | High-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation显示文摘The scarcity of liver grafts in Asia leads to a significant dropout of patients from liver transplant waiting lists, particularly patients with hepatocellular carcinoma and a low model for end-stage liver disease score. In order to reduce dropping out, different bridging therapies are employed. We report the use of high-intensity focused ultrasound ablation as a bridging therapy for a patient with hepatocellular carcinoma of stage two and an extremely low platelet count (20×10 9 /L). The ablation was successful. Blood tests showed that his liver function was similar before and after the treatment. No adhesion was encountered in the liver transplantation performed six months later. | Tan To Cheung Kenneth SH Chok Regina CL Lo William W Sharr See Ching Chan Ronnie TP Poon Sheung Tat Fan Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 3 |
| 5 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 6 | Hepatectomy for hepatocellular carcinoma: toward zero hospital deaths显示文摘 | Fan ST Lo CM Liu CL | 1999 | Ann Surg1999，229，3： | 1 |
| 7 | A randomized,controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma显示文摘 | Lo CM Liu CL Chan SC | | 0，，06： | 1 |
| 8 | Safety of duct-to-duct biliary reconstruction in right-lobe live-donor liver transplantation without biliary drainage显示文摘 | Liu CL Lo CM Chan SC | 2004 | Transplantation2004，77，5： | 1 |
| 9 | Choledochal cysts in adults 显示文摘 | Liu CL Fan ST Lo CM | 2002 | Arch Surg2002，137，4： | 1 |
| 10 | Technical refinement in adult-to-adult living donor liver transplantation using right lobe graft 显示文摘 | Fan ST Lo CM Liu CL | 2000 | AnnSurg2000，231，1： | 1 |
| 11 | Minimum graft size for successful living donor liver transplantation显示文摘 | Lo CM Fan ST Liu CL | 1999 | Transplantation1999，68，8： | 1 |
| 12 | Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function:implications for a strategy of salvage transplantation显示文摘 | Poon RT Fan ST Lo CM Liu CL Wong J | | 0，，03： | 1 |
| 13 | The role and limitation of living donor liver transplantation for hepatocellular carcinoma 显示文摘 | Lo CM Fan ST Liu CL | 2004 | Liver Transpl2004，10，3： | 1 |
| 14 | Anterior approach for major right hepatic resection for large hepatocellular carcinoma显示文摘 | Liu CL Fan ST Lo CM | 2000 | Ann Surg2000，232，1： | 1 |
| 15 | Anterior approach for major right hepatic resection for large hepatocellular carcinoma 显示文摘 | Liu CL Fan ST Lo CM | 2000 | Ann Surg2000，232，1： | 1 |
| 16 | Safety of donors in live donor liver transplantation using right lobe grafts显示文摘 | Fan ST Lo CM Liu CL | 2000 | Arch Surg2000，135，3： | 1 |
| 17 | Extending the limit on the size of adult recipient in living donor liver transplantation using extended right lobe graft显示文摘 | Lo CM Fan ST Liu CL | 1997 | Transplantation1997，63，10： | 1 |
| 18 | Management of sponteneous rupture of hepatocellular carcinoma, single-center experience显示文摘 | LIU CL FAN ST LO CM | 2001 | J Clin Oncol2001，19，： | 1 |
| 19 | A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepa- tocellular carcinoma显示文摘 | Lo CM Liu CL Chan SC | 2007 | Ann Surg2007，245，6： | 1 |
| 20 | Risk factors for biliary complications after liver transplantation 显示文摘 | Qian YB Liu CL Lo CM | 2004 | Arch Surg2004，139，10： | 1 |
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