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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | Effects of salvianolic acid-A on NIH/3T3 fibroblast proliferation,collagen synthesis and gene expression显示文摘AIM To investigate the mechanisms ofsalvianolic acid A(SA-A)against liver fibrosisin vitro.METHODS NIH/3T3 fibroblasts were culturedroutinely,and incubated with 10-4mol/L-10-7mol/L SA-A for 22 h.The cell viability wasassayed by[3H]proline incorporation,cellproliferation by[3H]TdR incorporation,cellcollagen synthetic rate was measured with[3H]proline impulse and collagenase digestionmethod.The total RNA was prepared from thecontrol cells and the drug treated cellsrespectively,and α(1)I pro-collagen mRNAexpression was semi-quantitatively analyzedwith RT-PCR.RESULTS 10-4mol/L SA-A decreased cellviability and exerted some cytotoxiciy,while10-5mol/L-10-7mol/L SA-A did not affect cellviability,but inhibited cell proliferationsignificantly,and 10-6mol/L SA-A had the besteffect on cell viability among theseconcentrations of drugs.10-5mol/L-10-6mol/LSA-A inhibited intracellular collagen syntheticrate,but no significant influence on extracellularcollagen secretion.Both 10-5mol/L and10-6mol/L SA-A could decrease α(1)I pro-collagen mRNA expression remarkably.CONCLUSION SA-A had potent action againstliver fibrosis.It inhibited NIH/3T3 fibroblastproliferation,intracellular collagen syntheticrate and type I pro-collagen gene expression,which may be one of the main mechanisms of thedrug. | Liu CH Hu YY Wang XL Liu P Xu LM | 2000 | World Journal of Gastroenterology2000，6，3： | 25 |
| 3 | 普萘洛尔治疗婴幼儿血管瘤的初步经验显示文摘普萘洛尔是治疗婴幼儿血管瘤的新药物,但目前缺少对该药物治疗效果的系统评价。该文应用回顾性研究的方法.以1个三级脉管性疾病中心的资料为研究对象.评价普萘洛尔治疗增殖期和消退期血管瘤的效果。应用治疗期间患者照片双盲对比及调查问卷,评判治疗效果及并发症。 | Buckmiller LM Munson PD Dyamenahalli U | 2010 | 中国口腔颌面外科杂志2010，8，4： | 23 |
| 4 | 疼痛闸门控制学说的构建与解构显示文摘1.概述
疼痛闸门控制学说的里程碑式的文章发表至今己接近50年,作者Melzack和Wall对疼痛机制做出了清晰的描述,后续的研究都参照闸门控制学说来进行评价,因此对这篇文章的讨论能够为该领域当时及之后的发展提供一个视窗,为现代疼痛理论的发展奠定坚实的理论基础。周围神经病变和电刺激研究为我们描绘了从外周依次经过脊髓、脑干和丘脑投射至皮层的疼痛通路。利用与疼痛机制有重要关联的刺激行为的观察结果建立了新的疼痛概念,闸门控制学说推动了此后疼痛机制的研究。 | Mendell LM 刘婷婷 | 2014 | 中国疼痛医学杂志2014，20，10： | 16 |
| 5 | Scutellarin protects oxygen/glucose-deprived astrocytes and reduces focal cerebral ischemic injury显示文摘Scutellarin, a bioactive flavone isolated from Scutellaria baicalensis, has anti-inflammatory, anti-neurotoxic, anti-apoptotic and anti-oxidative effects and has been used to treat cardiovascular and cerebrovascular diseases in China. However, the mechanisms by which scutellarin mediates neuroprotection in cerebral ischemia remain unclear. The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2(NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity. Cultures of primary astrocytes isolated from the cerebral cortex of neonatal Sprague-Dawley rats were pretreated with 2, 10 or 50 μM scutellarin for 30 minutes. The astrocytes were then subjected to oxygen/glucose deprivation by incubation for 2 hours in glucose-free Dulbecco's modified Eagle's medium in a 95% N2/5% CO_2 incubator, followed by simulated reperfusion for 22 hours. Cell viability was assessed by cell counting kit-8 assay. Expression levels of NOX2, connexin 43 and caspase-3 were assessed by western blot assay. Reactive oxygen species were measured spectrophotometrically. Pretreatment with 10 or 50 μM scutellarin substantially increased viability, reduced the expression of NOX2 and caspase-3, increased the expression of connexin 43, and diminished the levels of reactive oxygen species in astrocytes subjected to ischemia-reperfusion. We also assessed the effects of scutellarin in vivo in the rat transient middle cerebral artery occlusion model of cerebral ischemia-reperfusion injury. Rats were given intraperitoneal injection of 100 mg/kg scutellarin 2 hours before surgery. The Bederson scale was used to assess neurological deficit, and 2,3,5-triphenyltetrazolium chloride staining was used to measure infarct size. Western blot assay was used to assess expression of NOX2 and connexin 43 in brain tissue. Enzyme-linked immunosorbent assay was used to detect 8-hydroxydeoxyguanosine(8-OHd G), 4-hydroxy-2-nonenal(4-HNE) and 3-nitrotyrosin(3-NT) in brain tissue. Immunofluorescence double staining was used to determine the co-expression of caspase-3 and Neu N. Pretreatment with scutellarin improved the neurological function of rats with focal cerebral ischemia, reduced infarct size, diminished the expression of NOX2, reduced levels of 8-OHd G, 4-HNE and 3-NT, and reduced the number of cells co-expressing caspase-3 and Neu N in the injured brain tissue. Furthermore, we examined the effect of the NOX2 inhibitor apocynin. Apocynin substantially increased connexin 43 expression in vivo and in vitro. Collectively, our findings suggest that scutellarin protects against ischemic injury in vitro and in vivo by downregulating NOX2, upregulating connexin 43, decreasing oxidative damage, and reducing apoptotic cell death. | Jing-Bo Sun Yan Li Ye-Feng Cai Yan Huang Shu Liu Patrick KK Yeung Min-Zhen Deng Guang-Shun Sun Prince LM Zilundu Qian-Sheng Hu Rui-Xin An Li-Hua Zhou Li-Xin Wang Xiao Cheng | 2018 | Neural Regeneration Research2018，13，8： | 16 |
| 6 | Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors显示文摘 | Petrella JR Shah LM Harris KM Friedman AH George TM Sampson JH Pekala JS Voyvodic JT | 2006 | 中国神经肿瘤杂志2006，4，2： | 14 |
| 7 | 缺血性脑卒中和出血性脑卒中患者发病前后血压的变化显示文摘《中国高血压防治指南2010》指出,急性脑卒中的血压处理缺乏足够的临床试验证据,参考建议如下:急性脑卒中溶栓前血压应控制在<185/110mm Hg(1mm Hg=0.133kPa)。对急性缺血性脑卒中发病24h内血压升高的患者应谨慎处理,收缩压≥180mm Hg或舒张压≥100mm Hg或伴有严重心功能不全、主动脉夹层、高血压脑病者,一般不予降压。降压的合理目标是24h内血压降低约15%。有高血压病史且正在服用降压药物者,如神经功能平稳,可于脑卒中发病后24h开始使用降压药物。因此,了解脑卒中患者发病前后的血压情况对临床治疗有重要的意义。Fischer等研究者探讨缺血性脑卒中和出血性脑卒中患者发病前后血压的变化情况。结果表明,缺血性脑卒中患者发病后首次测量的收缩压低于出血性脑卒中。与发病前比较,缺血性脑卒中发病后收缩压略升高(约10.6mm Hg),24h内轻度降低(约13.6mm Hg);而出血性脑卒中发病后,收缩压明显升高(约40.7mm Hg),24h内明显下降(约41.1mm Hg)。出血性脑卒中发病前几天及几周的平均收缩压逐渐增加,而缺血性脑卒中无明显变化。出血性脑卒中患者发病3h内的最高收缩压比发病前高50.0 mm Hg,而缺血性脑卒中则低5.2mm Hg。综上所述,与发病前比较,出血性脑卒中发病后收缩压升高,而缺血性脑卒中无明显变化。 | Fischer U Cooney MT Bull LM Silver LE Chalmers J Anderson CS Mehta Z Rothwell PM 林东杰 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 13 |
| 8 | Redistribution of carbon flux in Torulopsis glabrata by altering vitamin and calcium level显示文摘 | Liu, LM Li, Y Zhu, Y Du, GC Chert, J | 2007 | 中国生物学文摘2007，21，10： | 12 |
| 9 | 低量强力霉素对牙周炎患者龈沟液胶原酶等活性的影响显示文摘为探讨低剂量强力霉素对牙周炎患者龈沟液中多种酶活性的抑制作用,作者对5例慢性成人牙周炎患者,经分别口服空白剂,强力霉素40mg/d,强力霉素20mg/d及停药共4个阶段,测量各自龈沟液量及龈沟液胶原酶、弹性蛋白酶、β-葡萄糖醛酸酶活性。结果:在口服强力霉素40mg/d时,其龈沟液量及酶活性均较用药前明显下降(P<0.01),且连续服用2周无明显副作用,可间隔1个月后重新用药。 | 沙月琴 Go.,LM | 1995 | 中华口腔医学杂志1995，30，5： | 6 |
| 10 | 高血压眼病的高血压视网膜病变脉络膜病变和视神经病变分期...显示文摘 | 曹安民 Jamp.,LM | 1990 | 眼底病1990，6，4： | 6 |
| 11 | 急性缺血性脑卒中后低脉压与不良预后相关显示文摘众所周知,脉压与心脏功能、动脉僵硬度、体液状态和血管事件有关。该研究旨在探讨基于中国台湾地区脑卒中登记资料的急性缺血性脑卒中(acute ischemic stroke,AIS)患者入院时脉压的预后作用。 | 刘莉 叶鹏 Tang SC Yin JH Liu CH Sun MH Lee JT Sun Y Hsu CS Sun MC Lin CH Chen CH Lien LM Muo CH Jeng JS Hsu CY | 2017 | 中华高血压杂志2017，25，7： | 5 |
| 12 | 自发性卵巢早衰并不等同于早绝经显示文摘 | Nelson LM 汝炜(摘) 钟慧萍(校) 汪昭葵(校) | 2006 | 国外医学(计划生育.生殖健康分册)2006，25，5： | 5 |
| 13 | Initial sequencing and analysis of the human genome显示文摘 | Lander ES Linton LM Birren B | | 0，，： | 4 |
| 14 | Glucocorticoids upregulate transepithelial electrical resistance and expression of tight junction-related protein in human trabecular meshwork cells显示文摘 | ZHUO Ye-hong, HUANG Ya-lin, WEI Yan-tao, LING Yun-lan, LIN Ming-kai and GE Jian Key Laboratory of Ophthalmology, Ministry of Education Zhongshan Ophtha lm ic Center , Sun Yat-sen University, Guangzhou 510060, China | 2005 | Chinese Medical Journal2005，，20： | 4 |
| 15 | Is acute dyspnea related to oxaliplatin administration?显示文摘The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin. Oxaliplatin improves the ef-ficacy of this combination in patients with stage Ⅲ colon cancer and moreover its toxicity is well tolerable. We de-scribe a rare clinical case of acute dyspnoea probably re-lated to oxaliplatin at one month from the end of the ad-juvant treatment. A 74-year-old man developed a locally advanced sigmoid carcinoma (pT3N1M0). A port a cath attached to an open-ended catheter was implanted in order to administer primary chemotherapy safely according to the FOLFOX4 schedule. One month following the end of the 6th cycle, the patient referred a persistent cough and moderate dyspnoea. Chest radiography displayed a change in the lung interstitium, chest CT scan con-firmed this aspect of adult respiratory distress syndrome, spirometry reported a decreased carbon monoxide diffu-sion capacity. Antibiotic and corticosteroids were admin-istered for 10 d, then a repeated chest X ray evidenced a progressive pulmonary infiltration. A transbronchial biopsy and cytology did not show an infective process, a CT scan reported radiological abnormalities including linear and nodular densities which were becoming con-fluents. Antimicotic and antiviral drugs did not evidence any benefit. The antiviral therapy was stopped and high dose metilprednisolone was started. The patient died of pulmonary distress after 10 d. | LM Pasetto S Monfardini | 2006 | World Journal of Gastroenterology2006，12，36： | 4 |
| 16 | The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression显示文摘The leading form of dementia worldwide,Alzheimer's disease(AD)is a common neurodegenerative disorder.The underlying causes of AD are not well understood,and no current treatments are preventing the onset or delay progression of the disease.Currently,most investigation is directed towards the amyloid-beta(Aβ)and tau pathologies,中文标题:The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression中文关词:Glu;AMPAR;APP;The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression;中文摘要:The leading form of dementia worldwide,Alzheimer's disease(AD)is a common neurodegenerative disorder.The underlying causes of AD are not well understood,and no current treatments are preventing the onset or delay progression of the disease. | Andrea Kwakowsky Henry J.Waldvogel Richard LM Faull | 2021 | Neural Regeneration Research2021，16，7： | 4 |
| 17 | Subtropical urban turfs: Carbon and nitrogen pools and the role of enzyme activity显示文摘Urban grasslands not only provide a recreational venue for urban residents, but also sequester organic carbon in vegetation and soils through photosynthesis, and release carbon dioxide through respiration, which largely contribute to carbon storage and fluxes at regional and global scales. We investigated organic carbon and nitrogen pools in subtropical turfs and found that dissolved organic carbon(DOC) and dissolved organic nitrogen(DON)were regulated by several factors including microbial activity which is indicated by soil enzymatic activity. We observed a vertical variation and different temporal patterns in both soil DOC, DON and enzyme activities, which decreased significantly with increasing soil depths. We further found that concentration of soil DON was linked with turf age. There were correlations between grass biomass and soil properties, and soil enzyme activities. In particular, soil bulk density was significantly correlated with soil moisture and soil organic carbon(SOC). In addition, DOC correlated significantly with DON. Significant negative correlations were also observed between soil total dissolved nitrogen(TDN) and grass biomass of Axonopus compressus and Zoysia matrella. Specifically, grass biomass was significantly correlated with the soil activity of urease and β-glucosidase. Soil NO3-N concentration also showed negative correlations with the activity of both β-glucosidase and protease but there were no significant correlations between cellulase and soil properties or grass biomass. Our study demonstrated a relationship between soil C and N dynamics and soil enzymes that could be modulated to enhance SOC pools through management and maintenance practices. | Ling Kong LM Chu | 2018 | Journal of Environmental Sciences2018，30，3： | 3 |
| 18 | Determination and geological implication of O-Si isotope of the sediment core in the CC area, the Pacific Ocean显示文摘ONCE ocean floor was below the calcite compensation depth (CCD), deeper than 5000 m, it was widely covered with siliceous ooze or abyssal clay without abyssoconite. The samples of sediment core used in the present research were collected at No. 1787 station during DY85-04 cruise and are mostly of siliceous ooze or abyssal clay. Therefore, traditional and well-considered stable isotopic study using foraminifera has to be given up. Instead, stable isotopic | Wu, SY Ding, TP Meng, XW Bai, LM | 1997 | Chinese Science Bulletin1997，42，17： | 3 |
| 19 | Evaluation of the Effects of Cypermethrin on Female Reproductive Function by Using Rabbit Model and of the Protective Role of Chinese Propolis显示文摘对 cypermethrin 毒性的中国 propolis 的预防效果被执行卵巢和子宫组织病理学说,以及由描绘卵巢的功能,胚胎,和崽评估。Cypermethrin 在卵巢和子宫导致了 atypia,并且减少排卵地点和胚胎的数字。导致 Cypermethrin 的氧化应力在怀孕期间,减少后代的生产率以及数字和重量并且在后代增加了词法畸形性的发生。到对待 cypermethrin 的动物的 propolis 的管理减轻了导致 cypermethrin 的繁殖毒性。 | AE Khatab NM Hashem LM El-Kodary FM Lotfy GA Hassan | 2016 | Biomedical and Environmental Sciences2016，29，10： | 3 |
| 20 | SALVIAFLASIDE AND SALVIAFLASIDE METHYL ESTER TWO NEW DEPSIDIC GLYCOSIDES FROM SALVIA FLAVA显示文摘SALVIAFLASIDEANDSALVIAFLASIDEMETHYLESTERTWONEWDEPSIDICGLYCOSIDESFROMSALVIAFLAVA￥LiMinAHAO;WenYiHE;XiaoTianLIANGandLianNiangLI... | Zhao, LM He, WY Liang, XT Li, LN | 1996 | Chinese Chemical Letters1996，7，5： | 3 |
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