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| 1 | Protocatechuic acid from Alpinia oxyphylla against MPP+-induced neurotoxicity in PC12 cells显示文摘 | An LJ Guan S Shi GF Bao YM Duan YL Jiang B | 2006 | 中国生物学文摘2006，20，10： | 30 |
| 2 | A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis b virus显示文摘 | Yu, K Sheng, GP Sheng, JF Chen, YM Xu, W Liu, XL Cao, HC Qu, HB Cheng, YY Li, LJ | 2007 | 中国生物学文摘2007，21，11： | 25 |
| 3 | FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma显示文摘AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with hepaticapoptosis.METHODS FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD protein.The positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P<0.05).Inthose of grade Ⅰ-Ⅱ,8(38.1%)cases wereFADD positive,while only 2/18(11.1%)casesof grade Ⅲ-Ⅳ had detectable FADD protein(P<0.05).No relationship was found betweenFADD expression and other clinical features,such as gender,age,tumor size,differentiationor metastasis.ISEL positive cells can be seen inall cases of HCC.The hepatic apoptosis wasassociated with FADD expression as moreapoptotic cells were detected in those caseswhich had moderately to strongly positiveFADD,as compared with negative or weakpositive FADD cases(P<0.05).No relationshipwas found between FADD expression and hepaticapoptosis in non-cancerous adjacent livertissues.Fifteen of 39(38.5%)cases of HCCwere found positive for TRADD protein,andsimilar positive rate(37.5%)in non-cancerousadjacent liver tissues(P>0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P<0.05),Norelationship was found between TRADDexpression and gender,age,tumor size or gradeor metastasis,although 42.9% of HCC of gradeⅠ/Ⅱ showed positive TRADD which wasslightly higher than that of grade Ⅲ/Ⅳ(33.3%,P>0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver tissues.CONCLUSION Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to HCCdevelopment.The cell apoptosis in HCC isassociated with FADD expression.However,theexpression of TRADD does not correlate wellwith hepatic apoptosis in HCC. | Sun BH Zhao XP Wang BJ Yang DL Hao LJ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 4 | 多粘菌素B治疗耐多药病原菌研究进展显示文摘由于耐多药革兰阴性菌院内感染在全世界广泛流行,目前尚无新的针对性抗菌药物被研发,所以多粘菌素B又被应用于临床。目前多粘菌素B和粘菌素为这些感染治疗的最后选择。本文综述了多粘菌素B的微生物学、药代动力学、药效学和临床学资料。多粘菌素B在体外,对常见耐多药革兰阴性菌,如铜绿假单胞菌、鲍氏不动杆菌、肺炎克雷伯菌,有迅速杀灭作用。对其耐药的病原菌还很少见。近期研究显示,多粘菌素B静脉治疗后大部分患者疗效好。但这些研究由于存在设计缺陷,需要进行更多的临床研究。尽管体外试验结果提示联合治疗是不错选择,但没有临床的研究给予支持。鉴于多粘菌素类将越来越多地用于治疗耐多药病原菌感染,迫切需要进一步进行临床药代动力学、药效学和毒理学的研究,来指导该药的使用。 | Zavascki AP Goldanilz LJ 周颖杰 施耀国 | 2008 | 国际药学研究杂志2008，35，4： | 21 |
| 5 | Protocatechuic acid suppresses MPP(+)-induced mitochondrial dysfunction and apoptotic cell death in PC12 cells.显示文摘 | Guan S Jiang B Bao YM An LJ | 2006 | 中国生物学文摘2006，20，10： | 17 |
| 6 | 多发肝癌免疫基因组特征及免疫逃逸机制的探究显示文摘【据《J Hepatol》2020年5月报道】题:多发肝癌免疫基因组特征及免疫逃逸机制的探究(作者Dong LQ等)多灶性肿瘤是肝癌常见的一种临床特征,其基因起源可能是由肝内转移(IM)或多中心独立发生(MO)而来的。本研究旨在探究多发肝癌基因组结构、异质性基因组结构对其免疫浸润及特征的影响,以及不同病灶差异化的免疫逃逸机制,从而针对其多病灶开发覆盖个体化的免疫治疗策略。 | 高强 董良庆 PENG LH MA LJ | 2020 | 临床肝胆病杂志2020，36，6： | 17 |
| 7 | Portal vein embolization by fine needle ethanol injection :experimental and clinicalstudies显示文摘AIM To improve the technique of intraportal embolization (PVE) therapy, a new embolic method, was devised and the safety, effectiveness and feasibility were evaluated. METHODS PVE with intraportal ethanol injection via a fine needle was performed in 28 normal dogs, 22 SD rats, and 24 cirrhotic SD rats. After PVE, portography, histological and functional alteration of the liver were evaluated in dogs and rats, and the changes in portal hemodynamics as well as hepatic anatomy were observed in rats. In the clinical study, PVE by ethanol injection was performed in 61 patients with hepatocellular carcinoma under the guidance of portoechography with intraportal injection of CO 2. The effect of PVE was evaluated by ultrasonography and laparotomy. RESULTS The effectiveness and toxicity were dependent on the dose of ethanol. In the dogs, 0 25*!mg/*!kg of ethanol caused incomplete embolization with least liver damage, while 1 0*!mg/*!kg induced complete embolization with a high mortality of 57 1% (4/*!7) due to respiratory arrest. The dose of 0 5*!mg/*!kg resulted in complete embolization with slight toxicity to the liver. In the rats, the survival rate was 100% in normal group but 40 9% in cirrhotic models after ethanol injection by dose of 0 05*!mg/*!100*!g . PVE for cirrhotic rats with 0 03*!mg/*!100*!g of ethanol induced satisfactory embolization with significant hypertrophy in nonembolized lobes, and only slight damage to the hepatic parenchyma, and transient alteration in liver function, portal pressure and portal flow. In the clinical study, 12 cases with reverse portal flow were excluded judged by portoechography. Satisfactory embolization was gained in 90 2% (55/*!61) of the remaining patients determined by ultrasonography and surgery. All cases ran an uneventful postembolization course with no aberrant embolization. CONCLUSION PVE with intraportal ethanol injection of appropriate dosage via a fine needle is safe and effective and has several advantages comparing with transcatheter method. Portoechography is a mandatory approach for the prevention of aberrant embolization. | Lu MD Chen JW Xie XY Liang LJ Huang JF | 1999 | World Journal of Gastroenterology1999，5，6： | 15 |
| 8 | 改善高血压患者的药物依从性:一项随机研究显示文摘治疗高血压和血脂异常能显著降低心血管事件和脑卒中风险,但服用降压药和降脂药的依从性差及没有持续性的现象仍很常见。数十年来已经对改善药物依从性的干预措施进行了较深入研究,即使采用了复杂的干预措施,其作用也很有限。一个可能的解释是不依从性受多因素影响。目前药物依从性研究的范围应倾向于个体化的治疗策略,而不是标准化干预,例如临床药师干预着重于关注患者药物相关问题和依从性行为。 | Hedegaard U Kjeldsen LJ Pottegard A Henriksen JE Lambrechtsen J Hangaard J Hallas J | 2015 | 中华高血压杂志2015，23，12： | 15 |
| 9 | Overexpression of P-glycoprotein in hepatocellular carcinoma and its clinical implication显示文摘INTRODUCTIONMost advanced hepatocellular garcinoma (HCC) isinsensitive to most anticancer drugs which might berelated to the high frequency of expression of themultidrug resistance-1(MDR1) gene and itsproduct,P-glycoprotein (p-gp).p-gp expressionmay also be concerned with tumor progression anddifferentiation.In the present study。 | Kong XB Yang ZK Liang LJ Huang JF Lin HL | 2000 | World Journal of Gastroenterology2000，6，1： | 13 |
| 10 | ISUOG早孕期胎儿超声扫查应用指南解读显示文摘目前国际公认的胎儿解剖结构超声评估的孕周为中孕期,但早孕期开展胎儿超声扫查可使胎儿畸形筛查时间提前、及早筛查胎儿染色体异常软标记,为致死性胎儿畸形的孕妇提供较早终止妊娠的机会。因此,早孕期胎儿超声扫查受到越来越多的重视,已成为产前超声研究的重要方向。国际妇产科超声学会(The International Society of Ultrasound in Obstetrics and Gynecology,ISUOG)临床标准委员会(Clinical Standards Committee,CSC)2013年发表了早孕期胎儿超声扫查影像诊断实用指南,本文对其主要内容予以解读。 | 田源 吴青青 王莉 Salomon LJ Alfirevic Z Bilardo CM | 2014 | 中华医学超声杂志(电子版)2014，11，4： | 12 |
| 11 | Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine显示文摘 | Zhao P Cao J Zhao LJ Ke JS Pan W Ren H Yu JG Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 12 |
| 12 | 前交叉韧带重建术后感染的相关因素显示文摘前交叉韧带(anterior cruciate ligament,ACL)重建术后感染相对少见,但一旦发生,情况非常严重,潜在威胁大。近期研究表明,移植物选择可能是ACL重建术后感染的危险因素之一,吸烟、肥胖、糖尿病等亦与骨科等外科手术术后感染密切相关。本研究的目的在于探究ACL重建术后感染与患者年龄、体质量指数(body mass index,BMI)、吸烟、糖尿病、移植物选择等潜在危险因素的相关性。 | Brophy RH Wright RW Huston LJ 胡玮 | 2015 | 中国骨科临床与基础研究杂志2015，7，4： | 10 |
| 13 | In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism. | Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle | 2016 | Bone Research2016，4，1： | 9 |
| 14 | Arteriovenous fistulas and digital hypoperfusion ischemic syndrome in patients on hemodialysis显示文摘AIM: To determine survival parameters as well as characteristics of patients with this syndrome. METHODS: The investigation was conducted over a period of eight years, as a prospective, non-randomized, clinical study which included 204 patients, treated by chronic hemodialysis. Most patients received hemodialysis 12 h per week. As vascular access for hemodialysis all subjects had an arteriovenous fistulae. Based on surveys the respondents were divided into groups of patients with and without digital hypoperfusion ischemic syndrome. Gender, demographic and anthropometric characteristics, together with comorbidity and certain habits, were recorded. During this period 34.8% patients died.RESULTS: Patients with digital hypoperfusion ischemic syndrome were older than those without ischemia(P = 0.01). Hemodialysis treatment lasted significantly longer in the patients with digital hypoperfusion ischemic syndrome(P = 0.02). The incidence of cardiovascular disease(P < 0.001) and diabetes mellitus(P = 0.01), as well as blood flow through the arteriovenous fistula(P = 0.036), were higher in patients with digital hypoperfusion ischemic syndrome. Statistically significant differences also existed in relation to oxygen saturation(P = 0.04). Predictive parameters of survival for patients with digital hypoperfusion ischemic syndrome were: adequacy of hemodialysis(B =-3.604, P < 0.001), hypertension(B =-0.920, P = 0.018), smoking(B =-0.901, P = 0.049), diabetes mellitus(B = 1.227, P = 0.005), erythropoietin therapy(B = 1.274, P = 0.002) and hemodiafiltration(B =-1.242, P = 0.033). KaplanMeier survival analysis indicated that subjects with and without digital hypoperfusion ischemic syndrome differed regarding the length of survival(P < 0.001), i.e., patients with confirmed digital hypoperfusion ischemic syndrome died earlier.CONCLUSION: Survival was significantly longer in the patients without digital hypoperfusion ischemic syndrome. | Radojica V Stolic Goran Z Trajkovic Dijana J Miric Bojana Kisic Zorana Djordje Goran Lj Azanjac Marijana S Stanojevic Dragica Z Stolic | 2013 | World Journal of Nephrology2013，2，2： | 8 |
| 15 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011，30，1： | 8 |
| 16 | 与HBeAg阴性慢性乙型肝炎患者成功停药相关的病毒和免疫因素显示文摘【据Journal of Hepatology 2020年12月报道】与HBeAg阴性慢性乙型肝炎患者成功停药相关的病毒和免疫因素(作者García-López M等)目前,与HBeAg阴性慢性乙型肝炎(CHB)患者成功停用核苷(酸)类似物(NA)治疗的相关因素尚未阐明。为了分析停用NA患者的HBV特异性T淋巴细胞反应以及外周和肝内病毒参数,来自西班牙巴塞罗那大学的García-López等对27例病毒完全抑制(>3年)HBeAg阴性CHB非肝硬化患者进行了前瞻性研究。在基线时定量检测肝内HBV DNA(iHBV DNA)、肝内HBV RNA(iHBV RNA)和共价闭合环状DNA(cccDNA)。此外,在基线和整个随访过程中,对血清标志物(HBV DNA、HBsAg、HBcrAg和HBV RNA)和HBV特异性T淋巴细胞反应进行了分析。 | GARCIA-LOPEZ M LENS S PALLETT LJ 孟方园 高沿航 | 2021 | 临床肝胆病杂志2021，37，2： | 8 |
| 17 | 钠摄入量与血压的关系随能量摄入而变化:终止高血压膳食研究-钠试验的二次分析显示文摘膳食钠的摄入量是以绝对量(mg/d)表示而不是以钠密度(mg/kcal)表示的。研究者旨在确定钠摄入量与血压关系的强弱是否随着能量摄入量而变化。终止高血压膳食研究(dietary approaches to stop hypertension,DASH)-钠试验是比较2种膳食(DASH和对照)和3种钠密度水平的随机膳食摄入试验。 | 刘青 叶鹏 Murtaugh MA Beasley JM Appel LJ Guenther PM McFadden M Greene T Tooze JA | 2018 | 中华高血压杂志2018，26，6： | 7 |
| 18 | 遮荫程度及其持续时间对花生生长和产量的影响显示文摘 | Rao,LJ 赵作屏 | 1989 | 国外农学(农业气象)1989，，2： | 7 |
| 19 | Effect of temperature field on solidification structure of pure Al under pulse magneto-oscillation显示文摘This article discusses the effect of temperature field on the Pulse Magneto-Oscillation(PMO) induced solidification refinement of pure aluminium to provide more information for the industrial application of the PMO solidification technology.The temperature field is altered mainly by applied variable cooling conditions and pulse parameters.Experimental results show that the refinement effect in the case of full sand mould applied is weakened with the decreasing of cooling rate,however,in the alternative case,the sand mould whose sand bottom was replaced by a graphite block is favorable to the survival of equiaxed nucleus.The refinement mechanism is discussed in terms of the relationship between temperature field and the formation process of solidified structure.The formation or survival of nucleus depends on both temperature field and Joule heat produced by PMO,both low pulse frequency and high pulse current were experimentally confirmed to be effective;and PMO was demonstrated high potential in industrial application. | Li Bo Yin Zhenxing Gong Yongyong LJ Kefeng Zheng Hongxing Li Renxing Zhai Qijie | 2011 | China Foundry2011，8，2： | 6 |
| 20 | Platelet activating factor/platelet activating factor receptor pathway as a potential therapeutic target in autoimmune diseases 显示文摘 | Edwards LJ Constantinescu CS | 2009 | lnflamm Allergy Drug Targets2009，8，3： | 6 |
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