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| 1 | Targeting BMI-1-mediated epitheliale-mesenchymal transition to inhibit colorectal cancer liver metastasis显示文摘Liver is the most common metastatic site for colorectal cancer(CRC),there is no satisfied approach to treat CRC liver metastasis(CRCLM).Here,we investigated the role of a polycomb protein BMI-1 in CRCLM.Immunohistochemical analysis showed that BMI-1 expression in liver metastases was upregulated and associated with T4 stage,invasion depth and right-sided primary tumor.Knockdown BMI-1 in high metastatic HCT116 and LOVO cells repressed the migratory/invasive phenotype and reversed epithelialemesenchymal transition(EMT),while BMI-1 overexpression in low metastatic Ls174 T and DLD1 cells enhanced invasiveness and EMT.The effects of BMI-1 in CRC cells were related to upregulating snail via AKT/GSK-3βpathway.Furthermore,knockdown BMI-1 in HCT116 and LOVO cells reduced CRCLM using experimental liver metastasis mice model.Meanwhile,BMI-1 overexpression in Ls174 T and DLD1 significantly increased CRCLM.Moreover,sodium butyrate,a histone deacetylase and BMI-1 inhibitor,reduced HCT116 and LOVO liver metastasis in immunodeficient mice.Our results suggest that BMI-1 is a major regulator of CRCLM and provide a potent molecular target for CRCLM treatment. | Zhiyao Xu Zhuha Zhou Jing Zhang Feichao Xuan Mengjing Fan Difan Zhou Zhenyu Liuyang Ximei Ma Yiyang Hong Yihong Wang Sherven Sharma Qinghua Dong Guanyu Wang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 8 |
| 2 | 18例先天性内耳发育不良继发脑脊液耳漏诊疗总结(英文)显示文摘目的:介绍先天性内耳发育不良继发耳源性脑脊液渗漏的临床表现、诊断、手术方法及预后。创新点:总结了先天性内耳发育不良所致的脑脊液耳漏儿童与成人的畸形特点,为先天性内耳畸形导致的脑脊液耳漏提供诊疗参考。方法:回顾性分析2007~2017年我组18例内耳发育不良继发耳源性脑脊液渗漏患者,随访至少4个月,平均随访时间为3年。介绍所有患者的临床表现特点,包括自述症状、影像学表现、手术方法及修复方法、术中渗漏位置、术后病程、手术成功率等。结论:在先天性内耳发育不良所致的脑脊液耳漏中,儿童的内耳畸形情况较成人更为严重。最常见的症状是脑膜炎、听力障碍和脑脊液耳漏或鼻漏。高分辨率CT(HRCT)对本病具有较高的诊断准确率。最常见的瘘口位于椭圆窗周围,包括镫骨足板和环形韧带。 | Bing WANG Wen-jia DAI Xiao-ting CHENG Wen-yi LIUYANG Ya-sheng YUAN Chun-fu DAI Yi-lai SHU Bing CHEN | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，2： | 8 |
| 3 | Review on DFT calculation of s-triazine-based carbon nitride显示文摘To improve the photocatalytic performance of pristine photocatalysts,element doping,construction of composites and fabrication of novel nanostructures are recognized as universal modification methods.These methods have been experimentally verified to be effective in manifold photocatalytic application over various photocatalysts.Density functional theory(DFT)calculation is a powerful and fundamental tool to pinpoint the intrinsic mechanism of the enhanced photocatalytic activity.And it holds the degree of precision ranging from atoms,molecules to unit cells.Herein,recent DFT calculation research progress of modified s-triazine-based graphitic carbon nitride(g-C3N4)systems as photocatalysts is summarized.To specify,we collected information of doping site,formation energy,geometric,and electronic properties.We also discussed the synergistic effect of work function,Fermi level and band edge position on the built-in electric field,transfer route of photogenerated charge carriers and photocatalytic mechanism(traditional typeⅡor direct Z-scheme heterostructure).Moreover,we analyzed the geometric configuration,band structure,and stability of g-C3N4 nanocluster,nanoribbon,and nanotube.Finally,future perspective in the further theoretical revelation of g-C3N4-based photocatalysts is proposed. | Bicheng Zhu Bei Cheng Liuyang Zhang Jiaguo Yu | 2019 | Carbon Energy2019，1，1： | 8 |
| 4 | Step-scheme CdS/TiO_(2) nanocomposite hollow microsphere with enhanced photocatalytic CO_(2) reduction activity显示文摘Converting solar energy into chemical energy by artificial photosynthesis is promising in addressing the issues of the greenhouse effect and fossil fuel crisis.Herein,a novel photocatalyst,i.e.CdS/TiO_(2) hollow microspheres(HS),were dedicatedly designed to boost overall photocatalytic efficiency.TiO_(2) nanoparticles were in-situ decorated on the inside and outside the shell of Cd S HS,ensuring close contact between TiO_(2) and CdS.The CdS/TiO2 HS with abundant mesopores inside of the shell boost the light absorption via multiscattering effect as well as accessible to reactions in all directions.The heterojunction was scrutinized and the charge transfer across it was revealed by in-situ irradiated X-ray photoelectron spectroscopy(ISI-XPS).Ultimately,the charge transfer in this composite was determined to follow stepscheme mechanism,which not only facilitates the separation of charge carriers but also preserves strong redox ability.Benefited from the intimate linkage between Cd S and TiO_(2) and the favorable step-scheme heterojunction,enhanced photocatalytic CO_(2) reduction activity was accomplished.The CH4 yield rate of CdS/TiO_(2) reaches 27.85μmol g^(–1) h^(–1),which is 145.6 and 3.8 times higher than those of pristine CdS and TiO_(2),respectively.This work presents a novel insight into constructing step-scheme photocatalytic system with desirable performance. | Zhongliao Wang Yifan Chen Liuyang Zhang Bei Cheng Jiaguo Yu Jiajie Fan | 2020 | Journal of Materials Science & Technology2020，56，21： | 7 |
| 5 | Numerical Simulation on Temperature and Microstructure during Quenching Process of Large-sized AISI P20 Steel Die Blocks显示文摘In this paper, a model of coupled thermal and phase transformation is described. The temperature and microstructure during the quenching process for large-sized AISI P20 steel die blocks have been simulated using the finite element method (FEM). The optimum quenching technology of large-sized AISI P20 steel die blocks has been proposed based on the simulation results, which not only can effectively avoid quenching cracks and obtain deeper hardened depth, but also can improve the microstructure and properties of the large-sized die blocks. | SONGDong-li GUJian-feng ZHANGWei-min LIUYang PANJian-sheng | 2004 | 材料热处理学报2004，25，05B： | 7 |
| 6 | Ablation of C/SiC-HfC composite prepared by precursor infiltration and pyrolysis in plasma wind tunnel显示文摘Carbon fiber reinforced silicon carbide-hafnium carbide(C/SiC-HfC)composite was prepared by precursor infiltration and pyrolysis process.Then,ablation behavior of C/SiC-HfC was evaluated in plasma wind tunnel.It was found that oxide layer formed during ablation significantly influenced the surface temperature.Formation of dense HfO2 SiO2 layer under low heat flux led to stable surface temperature.Silica(SiO2)on the surface was gradually consumed when heat flux increased,resulting in conversion of HfO2-SiO2 on the surface to HfO2.Converted HfO2 with high catalytic cofficient absorbed more energy,causing gradual increase in the surface temperature.Formed oxide layer was destroyed at high heat flux and high stagnation point pressure.After carbon fiber lost the protection of HfO2-SiO2 layer,it burned immediately,leading to surface temperature jump. | Liuyang DUAN Lei LUO Liping LIU Yiguang WANG | 2020 | Journal of Advanced Ceramics2020，9，3： | 7 |
| 7 | S-scheme photocatalyst Bi2O3/TiO2 nanofiber with improved photocatalytic performance显示文摘In this study,a hierarchical Bi2O3/TiO2 fibrous composite was in-situ fabricated on an electrospun TiO2 nanofiber at ambient temperature.In the Bi2O3/TiO2 composite,S-scheme electron migration occurred between Bi2O3 and TiO2.In the photocatalytic degradation of phenol under simulated sunlight,the asprepared Bi2O3/TiO2 nanofibers considerably outperformed Bi2O3 nanoparticles and TiO2 nanofibers.This improvement is contributed by maintaining and effectively utilizing the useful carriers and consuming the useless holes and electrons,realized by the S-scheme heterojunction and hierarchical structure.This study also provides an alternative design fashion for photocatalysts. | Rongan He Haijuan Liu Huimin Liu Difa Xu Liuyang Zhang | 2020 | Journal of Materials Science & Technology2020，52，17： | 6 |
| 8 | Development mechanism of internal local corrosion of X80 pipeline steel显示文摘The occurrence and development mechanism of internal local corrosion has always been a controversial topic,and especially under flow conditions.In this paper,an improved high shear force loop was experimentally used,and local flow field is induced by simulating corrosion defects on the surface of X80 pipeline steel specimens.The characteristics of corrosion products deposited on the surface of specimens in CO2-saturated NACE solution were investigated by means of electrochemical impedance spectroscopy(EIS),scanning electron microscopy(SEM),X-ray diffraction(XRD),and energy dispersive spectrometry(EDS).The 3D micromorphology of the corrosion test surface after remove the corrosion scale used to measure the size of localized corrosion pit.Under the influence of local defects,the wall shear stress(WSS)and turbulent kinetic energy of local flow fields enhanced significantly,and pressure fluctuations in local flow field were induced.The results showed that the characteristics of surface corrosion products varied with flow velocity.The corrosion scales formed in various regions of specimens with defects exhibited different surface micro-morphologies and chemical compositions.Overall,these data offer new perspectives for better understanding the mechanisms behind local corrosion. | Zhuowei Tan Liuyang Yang Dalei Zhang Zhenbo Wang Frank Cheng Mingyang Zhang Youhai Jin | 2020 | Journal of Materials Science & Technology2020，47，14： | 6 |
| 9 | A chlorinated non-fullerene acceptor for efficient polymer solar cells显示文摘Improving the performance and reducing the manufacturing costs are the main directions for the development of organic solar cells in the future.Here,the strategy that uses chemical structure modification to optimize the photoelectric properties is reported.A new narrow bandgap(1.30 eV)chlorinated non-fullerene electron acceptor(Y15),based on benzo[d][1,2,3] triazole with two 3-undecylthieno[2’,3’:4,5] thieno[3,2-b] pyrrole fused-7-heterocyclic ring,with absorption edge extending to the near-infrared(NIR) region,namely A-DA’D-A type structure,is designed and synthesized.Its electrochemical and optoelectronic properties are systematically investigated.Benefitting from its NIR light harvesting,the fabricated photovoltaic devices based on Y15 deliver a high power conversion efficiency(PCE) of 14.13%,when blending with a wide bandgap polymer donor PM6.Our results show that the A-DA’D-A type molecular design and application of near-infrared electron acceptors have the potential to further improve the PCE of polymer solar cells(PSCs). | Mei Luo Can Zhu Jun Yuan Liuyang Zhou M.L.Keshtov D.Yu Godovsky Yingping Zou | 2019 | Chinese Chemical Letters2019，30，12： | 5 |
| 10 | Highly sensitive and miniature microfiber-based ultrasound sensor for photoacoustic tomography显示文摘A microfiber with large evanescent field encapsulated in PDMS is proposed and demonstrated for ultrasound sensing.The compact size and large evanescent field of microfiber provide an excellent platform for the interaction between optical signal and ultrasound wave,exhibiting a high sensitivity of 3.5 mV/kPa,which is approximately 10 times higher than the single-mode fiber sensor.Meanwhile,a phase feedback stabilization module is introduced into the coherent demodulation system for long-term stable measurement.In addition,a photoacoustic tomography experiment with the microfiber ultrasound sensor is implemented to verify the excellent performance on imaging,with the depth of 12 mm,the highest lateral resolution of 65μm and axial resolution of 250μm,respectively.The highly sensitive microfiber ultrasound sensor provides a competitive alternative for various applications,such as industrial non-destructive testing,biomedical ultrasound and photoacoustic imaging. | Liuyang Yang Yanpeng Li Fang Fang Liangye Li Zhijun Yan Lin Zhang Qizhen Sun | 2022 | Opto-Electronic Advances2022，5，6： | 5 |
| 11 | Wearable Alignment‑Free Microfber‑Based Sensor Chip for Precise Vital Signs Monitoring and Cardiovascular Assessment显示文摘Continuous pulse wave signals monitoring is the essential basis for clinical cardiovascular diagnosis and treatment.Recent researches show the majority of current electronic pulse sensors usually face challenges in electrical safety concern,poor durability and demanding precision in position alignment.Thus,a highly sensitive,inherently electrical safe,robust and alignment-free device is highly desired.Here,we present a wearable alignment-free microfber-based sensor chip(AFMSC)for precise vital signs monitoring and cardiovascular health assessment.The AFMSC comprises an optical micro/nano fber sensor(MNF)and a fexible soft liquid sac while the MNF sensor is used to perceive the physiological signals and the liquid sac is used to eliminate the misalignment.The real-time and accurate monitoring of the pulse signals was realized by tracking the optical power variation of transmitted light from MNF.Then,the cardiovascular vital signs extracted from radial artery pulse signals were used to evaluate cardiovascular health condition and the results were in accordance with human physiological characteristics.Moreover,the pulse signals from diferent arterial area,the respiration signals from chest and the radial pulse signals before and after exercise were detected and analyzed.The non-invasive,continuous and accurate monitoring of cardiovascular health based on the reported wearable and alignment-free device is promising in both ftness monitoring and medical diagnostics for cardiovascular disease prevention and diagnosis. | Liangye Li Yunfei Liu Changying Song Shunfeng Sheng Liuyang Yang Zhijun Yan Dora Juan Juan Hu Qizhen Sun | 2022 | Advanced Fiber Materials2022，4，3： | 5 |
| 12 | Solar fuel generation over nature-inspired recyclable TiO_(2)/g-C_(3)N_(4)S-scheme hierarchical thin-film photocatalyst显示文摘Preparation of efficient photocatalysts with ease of recovery in solar fuel generation is highly desired to achieve carbon neutralization in carbon dioxide(CO_(2))emissions.Inspired from the forest with superior light penetration and fast gas transport,a TiO_(2)/g-C_(3)N_(4)composite nanowire arrays(NAs)film with maximized light utilization is devised.It is achieved by in-situ coating a thin layer of g-C_(3)N_(4)(as the leaf)on the vertically-oriented TiO_(2)arrays(as tree trunks)on Ti foil(as soil).Benefiting from the effective charge separation by S-scheme charge transfer,intimate contact by the in-situ growth as well as the ingenious structure,the composite,readily recyclable,displays exciting performance in photocatalytic CO_(2)reduction.It is beyond doubt that the combination of heterojunction construction and“nature-inspired biomimetic photocatalyst”design promises practical applications and industrial use. | Libo Wang Xingang Fei Liuyang Zhang Jiaguo Yu Bei Cheng Yuhua Ma | 2022 | Journal of Materials Science & Technology2022，，17： | 4 |
| 13 | Alanine aminotransferase(OsAlaAT1)modulates nitrogen utilization,grain yield,and quality in rice显示文摘Widespread use of inorganic nitrogen fertilizers has increased yields of many grains, including rice (Oryza sativa L.);however, fertilizers are costly for farmers and cause serious environmental problems, such as soil acidification and water eutrophication (Guo et al., 2010, 2021;Liu et al., 2021). Improving nitrogen use efficiency(NUE) in rice offers a practical way to enhance grain yield and alleviate the environmental problems caused by overuse of nitrogen fertilizer. Identifying and characterizing genes involved in NUE provides crucial information for this aim. | Liangbing Fang Liuyang Ma Shaolu Zhao Ruijie Cao Guiai Jiao Peisong Hu Xiangjin Wei | 2022 | Journal of Genetics and Genomics2022，49，5： | 3 |
| 14 | Construction of nickel cobalt sulfide nanosheet arrays on carbon cloth for performance-enhanced supercapacitor显示文摘Materials featured with self-supported three-dimensional network,hierarchical pores and rich electrochemical active sites are considered as promising electrodes for pseudocapacitors.Herein,a novel strategy for the growth of nickel-cobalt bisulfide(Ni Co S)nanosheets arrays on carbon cloth(CC)as supercapacitor electrodes is reported,involving deposition of two-dimensional metal-organic framework(MOF)precursors on the CC skeletons,conversion of MOF into nickel-cobalt layered double-hydroxide by ion exchange process and formation of Ni Co S by a sulfidation treatment.The Ni Co S nanosheets with rough surface and porous structures are uniformly anchored on the CC skeletons.The unique architecture endows the composite(Ni Co S/CC)with abundant accessible active sites.Besides,robust electrical/mechanical joint between the nanosheets and the substrates is attained,leading to the improved electrochemical performance.Moreover,an asymmetric supercapacitor device is constructed by using Ni Co S/CC and activated carbon as a positive electrode and a negative electrode,respectively.The optimized device exhibits a high specific capacitance,large energy density and long cycle life.The Ni Co S/CC electrode with intriguing electrochemical properties and mechanical flexibility holds great prospect for next-generation wearable devices. | Tao Liu Jiahao Liu Liuyang Zhang Bei Cheng Jiaguo Yu | 2020 | Journal of Materials Science & Technology2020，47，12： | 3 |
| 15 | Optical Microfber Neuron for Finger Motion Perception显示文摘To achieve dexterous motion controlling of robot,the sensors that function like human neurons for motion perception are essential.In this work,a silica microfber probe-based optical neuron(MPON)for robot fnger motion detection is proposed.The silica microfber probe was fabricated by snapping a biconical silica optical microfber that drawn from the standard optical fbre.Then it was embedded into thin polydimethylsiloxane(PDMS)to detect and recognize motions of robotic fnger.Specifcally,a PDMS-Tefon-Microfber-Tefon-PDMS composite structure was prepared to protect the waveguide structure of silica microfber probe and avoid the environmental pollution.With the help of this composite structure,the proposed MPON achieved the accurate measurement of bending angle with large range and fast response.The repeatability and stability of MPON were also investigated.Additionally,diferent fnger motions were successfully distinguished through observing the output power variation of MPON.The proposed MPON could serve as the perceptron of robot hand,which could be applied in dexterous gesture control even human machine interaction. | Yanpeng Li Shijie Tan Liuyang Yang Liangye Li Fang Fang Qizhen Sun | 2022 | Advanced Fiber Materials2022，4，2： | 3 |
| 16 | The Composition of Colonic Commensal Bacteria According to Anatomical Localization in Colorectal Cancer显示文摘结直肠癌是由遗传突变、表观遗传改变、慢性炎症、饮食和生活方式等多因素引起的多阶段疾病。最新研究表明,肠道菌群是结直肠癌发展过程中的重要参与者。肠道菌群稳态的失调,可通过诱发炎症、调控宿主防御、氧化应激和改变细菌代谢产物等机制促进结直肠癌的发生发展。值得注意的是,肠道横、纵截面上不同解剖部位的驻留菌群有所不同。根据细菌在肠道中定植部位的不同,可将其划分为4种类型:肠腔共生菌、肠黏膜驻留菌、上皮驻留菌和淋巴组织驻留菌。由于结肠共生细菌的易位与结直肠癌的发展密切相关,结直肠癌相关细菌可有望成为用于结直肠癌诊断的非侵入且准确性高的新型生物标志物。本文旨在总结和概述肠道不同解剖部位中的肠道菌群在结直肠癌发生发展中的作用。 | Liuyang Zhao Xiang Zhang Tao Zuo Jun Yu | 2017 | Engineering2017，3，1： | 3 |
| 17 | A novel sparse feature extraction method based on sparse signal via dual-channel self-adaptive TQWT显示文摘Sparse signal is a kind of sparse matrices which can carry fault information and simplify the signal at the same time.This can effectively reduce the cost of signal storage,improve the efficiency of data transmission,and ultimately save the cost of equipment fault diagnosis in the aviation field.At present,the existing sparse decomposition methods generally extract sparse fault characteristics signals based on orthogonal basis atoms,which limits the adaptability of sparse decomposition.In this paper,a self-adaptive atom is extracted by the improved dual-channel tunable Q-factor wavelet transform(TQWT)method to construct a self-adaptive complete dictionary.Finally,the sparse signal is obtained by the orthogonal matching pursuit(OMP)algorithm.The atoms obtained by this method are more flexible,and are no longer constrained to an orthogonal basis to reflect the oscillation characteristics of signals.Therefore,the sparse signal can better extract the fault characteristics.The simulation and experimental results show that the selfadaptive dictionary with the atom extracted from the dual-channel TQWT has a stronger decomposition freedom and signal matching ability than orthogonal basis dictionaries,such as discrete cosine transform(DCT),discrete Hartley transform(DHT)and discrete wavelet transform(DWT).In addition,the sparse signal extracted by the self-adaptive complete dictionary can reflect the time-domain characteristics of the vibration signals,and can more accurately extract the bearing fault feature frequency. | Junlin LI Huaqing WANG Liuyang SONG | 2021 | Chinese Journal of Aeronautics2021，34，7： | 2 |
| 18 | Mechanical properties and finite element analysis of walnut under different cracking parts显示文摘In order to reduce mechanical damage and improve extraction quality of walnut kernel during walnut cracking,the Wen-185 walnut cultivar was selected as the research object,and the mechanical properties of walnut under different cracking parts were assessed by combining compression tests and finite element analysis(FEA)method.The compression test results showed that the relationships between rupture force and deformation of walnut were nonlinear,and the cracking process of shell mainly consisted of three stages(elastic stage,plastic stage and composite elastic-plastic stage).The best method to crack walnut was the spherical compression,and the peak value of rupture force and corresponding deformation were 211.83 N and 1.68 mm,respectively.In condition of spherical compression,the shell-breaking rate,first-grade kernel rate and whole kernel rate were(91.67±2.89)%,(88.33±2.89)%,(80.00±5.00)%,respectively.The FEA results indicated that spherical compression was also the suitable way to rupture walnut,which resulted in the obvious propagation trends of shell cracks and further a better integrity of extracting walnut kernel.Therefore,the spherical contact form between walnut and cracking parts may be considered to design the structural shape of key components of walnut cracking machines,which was consistent with the analysis of compression test results.The comparison between experiment results and FEA results showed that the established FEA model can be used to analyze the mechanical properties of walnut.The research results can provide references for the structural design and optimization of key components of cracking machines for walnut or other nut crops. | Hong Zhang Liuyang Shen Haipeng Lan Yong Li Yang Liu Yurong Tang Wen Li | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 2 |
| 19 | 单细胞蛋白的研究 Ⅱ.利用酒糟生产酵母蛋白饲料显示文摘试验于1985~1987年进行,本研究课题选育的117号和136号酵母诱变株生产的酒糟酵母蛋白饲料含蛋白质28.18%,且具备牲畜必需的10种氨基酸,经高温40℃驯化的酵母菌,回复到适温28℃培养,酵母细胞增殖率明显提高,采用混合菌比单一菌生产酒糟酵母蛋白饲料,蛋白质含量增加,在发酵浪中加入糖化酶,蛋白质含量相应增加,沉淀过滤速度显著加快,酒糟酵母蛋白饲料饲养牲猪,与鱼粉对比差异显著(p>0.05) | Section of Microbiology,Hunan Agricultural College Liuyang Wine Factory | 1989 | 湖南农学院学报1989，15，1： | 2 |
| 20 | Incorporation of cerium in zirconolite–sphene Synroc显示文摘 | Shanlin Wang Yuancheng Teng Lang Wu Kuibao Zhang Xuetan Ren Hang Yang Liuyang Xu | 2013 | 2013 (1-3)2013，，1： | 2 |
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