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| 1 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 2 | Intraspinal transplantation of CD34+ human umbilical cord blood cells after spinal cord hemisection injury improves functional recovery in adult rats显示文摘 | Zhao,ZM Li,HJ Liu,HY Lu,SH Yang,RC Zhang,QJ Han,ZC | 2005 | 中国生物学文摘2005，19，3： | 2 |
| 3 | Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages显示文摘 | Liu,YJ Lu,SH Xu,B Yang,RC Ren,Q Liu,B Lu,M Yan,FY Han,ZB Han,ZC | 2005 | 中国生物学文摘2005，19，3： | 2 |
| 4 | Systemic infusion of FLKI(+) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice显示文摘 | Fang,BJ Shi,MX Liao,LM Yang,SG Liu,YH Zhao,RC | 2005 | 中国生物学文摘2005，19，3： | 2 |
| 5 | Developing c - MET pathway inhibitors for cancer therapy : progress and challenges 显示文摘 | Liu X Newton RC Scherle PA | 2010 | Trends Mol Med2010，16，1： | 1 |
| 6 | Meta-analysis on the effect of mental imagery on motor recovery of the hemiplegic upper extremity function显示文摘 | Kho AY Liu KP Chung RC | 2014 | Aust OccupTherJ2014，61，2： | 1 |
| 7 | Intimal estrogen receptor(ER)beta,but not ERalpha expression,is correlated with coronary calcification and atherosclerosis in pre-and postmenopausal women显示文摘 | Christian RC Liu PY Harrington S | | 0，，： | 1 |
| 8 | Aging, cancer and nutri- tion : the DNA methylation connection 显示文摘 | Liu L Wylie RC Andrews LG | 2003 | Mechanisms of ageing and development2003，124，10： | 1 |
| 9 | Relationship between medium composition, inoeulumsize, temperature and euhure time in the yields of Steinernema and Heterorhabditis nematodes 显示文摘 | Han RC Cao L Liu XL | 1992 | Fundamental and Applied Nematology1992，15，3： | 1 |
| 10 | In vitro corrosion degra- dation behaviour of Mg-Ca alloy in the presence of albu- min显示文摘 | Liu CL Wang Y J Zeng RC | 2010 | Cot Sci2010，52，10： | 1 |
| 11 | Evaluation of a newly developed genoarray human papillomavirus(HPV) geno- typing assay and comparison With the roche linear array HPV genotyping assay显示文摘 | Liu SS Leung RC Chan KK | 2010 | J Clin Microbiol2010，48，3： | 1 |
| 12 | Effects of dezocine on postoperative sore throat after maxillofacial procedures:a comparison with flur- biprofen axetil显示文摘 | Jiao L Liu RC | 2014 | Beijing Da Xue Xue Bao2014，46，1： | 1 |
| 13 | Endoplasmic reticulum chaperones GRP78 and calreticulin prevent oxidative stress, Ca2+ disturbances, and cell death in renal epithelial cells显示文摘 | Liu H Bowes RC 3rd van de Water B | 1997 | J Biol Chem1997，272，21： | 1 |
| 14 | Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer 显示文摘 | Leung RC Liu SS Chan KY | 2008 | Oncol Rep2008，19，5： | 1 |
| 15 | Interleukin(IL)-6,tumour necrosis factor alpha(TNF-cL)and soluble interleukin-2 receptors(sIL-2R)are elevated in patients with major depressive disorder:a recta-analysis and recta-regression 显示文摘 | Liu Y Ho RC Mak A | 2012 | J Affect Disord2012，139，： | 1 |
| 16 | Stretching single tain rod molecules activates vinculin binding 显示文摘 | Del Rio A Perez-Jimenez R Liu RC | 2009 | Science2009，323，5914： | 1 |
| 17 | Aging, cancer and nutrition: the DNA methylation connection 显示文摘 | Liu L Wylie RC Andrews LG | 2003 | Mech Ageing Dev2003，124，1012： | 1 |
| 18 | A novel role of IGFBP7 in mouse uterus: regulating uterine receptivity through Thl/Th2 lymphocyte balance and decidualization 显示文摘 | Liu ZK Wang RC Han BC | 2012 | PLoS One2012，7，45： | 1 |
| 19 | Noninvasive monitoring of embryonic stem cells in vivo with MRI transgene reporter显示文摘 | Liu J Cheng EC Long RC | | 0，，04： | 1 |
| 20 | Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer 显示文摘 | Leung RC Liu SS Chan KY | 2008 | Oncol Rep2008，19，5： | 1 |
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