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您的检索式：作者名="Liting LAI"
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| 1 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 2 | Research Progress in Anti-tumor Effects of Traditional Chinese Medicine and Its Extracts显示文摘Traditional Chinese medicine and its extracts have received widespread attention due to their significant anti-tumor effects and low adverse reactions.Many traditional Chinese medicine and its extracts have been applied in clinical tumor treatment.In this paper,the research progress in anti-tumor effects of plant-based traditional Chinese medicine and its extracts,animal-based traditional Chinese medicine and its extracts,and traditional Chinese medicine compound is reviewed. | Jingjing LIAO Hong LEI Liting LAI Bing QING Wen ZHONG Yunli TANG | 2023 | Medicinal Plant2023，14，5： | 0 |
| 3 | The English Subtitle Translation of Quanzhou’s World Heritage Application Documentary: A Frame Theory Perspective显示文摘Based on Fillmore’s frame theory, this paper examines the translator’s cognitive frame operation in the English subtitle translation of Quanzhou’s World Heritage application documentary. It analyzes and discusses how the translator maximizes translation effect between the source language and the target language, so as to enhance the readability of documentary subtitles and promote the spread of traditional Chinese culture. The findings are as follows: Firstly, in the translation process, the frame operations used by the translator include frame correspondence, intra-frame operations, frame replacement, frame perspective shift and frame transplantation. Secondly, cultural documentaries are full of culture-loaded words, for which the translator usually uses frame transplantation. Thirdly, due to the instantaneous nature of subtitles, intra-frame operations and frame replacement are applied in terms of cultural background of the target language audience. Besides, in order to enhance the audience’s reading experience, there may be some changes of narrative perspective in the English translation of cultural documentaries. | LAI Liting CHEN Min | 2023 | Sino-US English Teaching2023，20，8： | 0 |
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