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| 1 | 晚期非小细胞肺癌免疫检查点抑制剂新型生物标志物:血液PD-L1动态检测显示文摘背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性肿瘤患者的肿瘤组织和配对血样本,进行PD-L1表达的相关性分析。40例晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受ICIs治疗,2个月时检测血液PD-L1(bloodPD-L1,bPD-L1)表达的动态变化,包括PD-L1 mRNA、外泌体PD-L1(exosomalPD-L1,exoPD-L1)蛋白和可溶性PD-L1(solublePD-L1,sPD-L1)。应用R软件计算最佳截断值,用于预测最佳客观缓解(best objective response,b OR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。结果51例不同恶性肿瘤患者中,组织PD-L1(tissuePD-L1,tPD-L1)表达阳性患者的PD-L1mRNA表达水平显著升高。40例接受ICIs治疗的晚期NSCLC患者中,bPD-L1 mRNA上调≥2.04的患者b OR、PFS和OS更佳;21例接受ICIs治疗的晚期NSCLC患者中,exoPD-L1上调≥1.86的患者临床获益更大。sPD-L1动态变化与ICIs疗效无显著相关性。PD-L1 mRNA和exoPD-L1联合检测更有利于预测ICIs治疗疗效。结论bPD-L1表达与tPD-L1表达存在正相关;晚期NSCLC患者ICIs治疗初期PD-L1 mRNA和(或)exoPD-L1表达升高,可作为评估临床获益的新型生物标志物。 | Qiao YANG Mingjing CHEN Jiaoyang GU Kai NIU Xianlan ZHAO Linpeng ZHENG Zihan XU Yongxin YU Feng LI Lingxin MENG Zhengtang CHEN Wenlei ZHUO Luping ZHANG Jianguo SUN 杨峤(译) 孙建国(译) | 2021 | 中国肺癌杂志2021，24，12： | 10 |
| 2 | Artificial Hair-Like Sensors Inspired from Nature: A Review显示文摘 | Zhiwu Han Linpeng Liu Kejun Wang Honglie Song Daobing Chen Ze Wang Shichao Niu Junqiu Zhang Luquan Ren | 2018 | Journal of Bionic Engineering2018，15，3： | 6 |
| 3 | Pathogenesis of allergic diseases and implications for therapeutic interventions显示文摘Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD), food allergy (FA), and eczema aresystemic diseases caused by an impaired immune system. Accompanied by high recurrence rates, the steadily rising incidence ratesof these diseases are attracting increasing attention. The pathogenesis of allergic diseases is complex and involves many factors,including maternal-fetal environment, living environment, genetics, epigenetics, and the body’s immune status. The pathogenesisof allergic diseases exhibits a marked heterogeneity, with phenotype and endotype defining visible features and associatedmolecular mechanisms, respectively. With the rapid development of immunology, molecular biology, and biotechnology, manynew biological drugs have been designed for the treatment of allergic diseases, including anti-immunoglobulin E (IgE), antiinterleukin(IL)-5, and anti-thymic stromal lymphopoietin (TSLP)/IL-4, to control symptoms. For doctors and scientists, it is becomingmore and more important to understand the influencing factors, pathogenesis, and treatment progress of allergic diseases. Thisreview aimed to assess the epidemiology, pathogenesis, and therapeutic interventions of allergic diseases, including AR, AAS, AD,and FA. We hope to help doctors and scientists understand allergic diseases systematically. | Ji Wang Yumei Zhou Honglei Zhang Linhan Hu Juntong Liu Lei Wang Tianyi Wang Haiyun Zhang Linpeng Cong Qi Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 3 |
| 4 | Crack-based and Hair-like Sensors Inspired from Arthropods:A Review显示文摘Over a long period of time,arthropods evolve to have two excellent mechanical sensilla of slit sensilla and trichobothria sensilla,which construct a perfect perception system.The former mainly perceives the change of the in-the-plane force while the latter perceives that of the out-of-plane force.In recent years,these two sensilla have attracted researchers as the models for developing artificial mechanical sensors.This review mainly includes the biomechanics and biomimetic manufacturing techniques as well as their future application value.In order to better understand the advantages of biological strategies,this review describes the morphology,mechanical analysis,and information recognition of slit sensilla and trichobothria sensilla.Then this review highlights the recent development of Crack-based Sensors(CBSs)and Hair-like Sensors(HLSs)based on the analysis of biological mechanism.The manufacturing method and substrate of crack in CBS and those of hair rods in HLS are discussed respectively.Finally,the practical applications and potential value of two sensilla,such as flexible wearable electronic devices,robot sensing system,autopilot sensing and wind tunnel speed detection,are briefly discussed. | Changchao Zhang Junqiu Zhang Daobing Chen Xiancun Meng Linpeng Liu Kejun Wang Zhibin Jiao Tao Sun Dakai Wang Shichao Niu Zhiwu Han Luquan Ren | 2020 | Journal of Bionic Engineering2020，17，5： | 2 |
| 5 | Micro/nano-scale Characterization and Fatigue Fracture Resistance of Mechanoreceptor with Crack-shaped Slit Arrays in Scorpion显示文摘The nocturnal scorpion Heterometrus petersii uses Basitarsal Compound Slit Sensilla (BCSS) as mechanoreceptor to detect mechanical signal (e.g. substrate vibration, cyclic loads caused by walking) without fatigue failure such as initiation of fatigue crack and further propagation of crack-shaped slit. The outstanding perceptive function has been discovered for over half a century. However, it is not yet clear about the microstructure, material composition and micromechanical property which are all important factors that determine the fatigue fracture resistance of the BCSS. Here, the microscopic characteristics of the BCSS were thoroughly studied. The results dicate that anti-fatigue resilin and stiff chitinous cuticle form multilayered composite as the main body of the BCSS. Meanwhile, the pre-existing slit as mechanosensory structure is covered by cuticular membrane which has different mechanical property with the epicuticle. Theoretical analysis shows that the structure-composition-property synergistic relations of composites confer on the BCSS with extreme fatigue fracture tolerance. | Kejun Wang Junqiu Zhang Yuqiang Fang Daobing Chen Linpeng Liu Zhiwu Han Luquan Ren | 2019 | Journal of Bionic Engineering2019，16，3： | 1 |
| 6 | Accurate Area, Time and Power Models for FPGA-based Implementation 显示文摘 | Deng Linpeng Sobti K Zhang Yuanrui | 2011 | Journal of Signal Processing Systems2011，63，1： | 1 |
| 7 | Nanowire-assisted microcavity in a photonic crystal waveguide and the enabled high-efficiency optical frequency conversions显示文摘We report an indium phosphide nanowire(NW)-induced cavity in a silicon planar photonic crystal(PPC)waveguide to improve the light–NW coupling.The integration of NW shifts the transmission band of the PPC waveguide into the mode gap of the bare waveguide,which gives rise to a microcavity located on the NW section.Resonant modes with��factors exceeding 103 are obtained.Leveraging on the high density of the electric field in the microcavity,the light–NW interaction is enhanced strongly for efficient nonlinear frequency conversion.Second-harmonic generation and sum-frequency generation in the NW are realized with a continuous-wave pump laser in a power level of tens of microwatts,showing a cavity-enhancement factor of 112.The hybrid integration structure of NW-PPC waveguide and the self-formed microcavity not only opens a simple strategy to effectively enhance light–NW interactions,but also provides a compact platform to construct NW-based on-chip active devices. | Linpeng Gu Liang Fang Qingchen Yuan Xuetao Gan Hao Yang Xutao Zhang Juntao Li Hanlin Fang Vladislav Khayrudinov Harri Lipsanen Zhipei Sun Jianlin Zhao | 2020 | Photonics Research2020，8，11： | 0 |
| 8 | Solvothermal Synthesis of TiO2/Bi2WOs Heterojunction Photocatalyst with Optimized Interface Structure and Enabled Photocatalytic Performance显示文摘 | Linpeng Jiang Shujie Wang Liyi Shi Yin Zhao Zhuyi Wang Meihong Zhang Shuai Yuan | 2017 | Chinese Journal of Chemistry2017，35，2： | 0 |
| 9 | LOPE:A Low-Overhead Payment Verification Method for Blockchains显示文摘With its characteristics of decentralization,security,data traceability,and tamper-resistance,the blockchain has been widely used in various domains.Considering the difference in the performance of the devices,the light client is proposed so that devices without the ability to store a full blockchain copy can also participate in the blockchain transactions.However,the light client has to communicate with full nodes and verify the authenticity of a transaction which brings in some extent of communication,computation,and storage overheads to the light client.These overheads cannot be ignored for some low-performance devices,such as embedded devices or Io T chips,and therefore the current light client scheme does not work in this situation.We propose LOPE(a Low-overhead payment v Erification method)for poor-capacity nodes in the blockchain system.In LOPE,a grouping protocol is designed to partition full nodes into groups to serve the verification requests of the light client.In addition,Practical byzantine fault tolerance(PBFT)is used to ensure the light client to get a credible result in spite of a few dishonest nodes existing in the group.We conduct LOPE and evaluate it in a testbed.The experiment results show that LOPE reduces more than half of the communication overhead,degrades the computation overhead of the light client to a large extent,and avoids the storage overhead of the hash roots of block headers in the light client.We also conduct theoretical analysis to show the performance improvement and security issues of LOPE. | ZHANG Ying HE Zhengyuan JIA Linpeng DING Donghui ZHANG Hanwen SUN Yi | 2021 | Chinese Journal of Electronics2021，30，2： | 0 |
| 10 | Integrating ASTER and GLASS broadband emissivity products using a multi-resolution Kalman filter显示文摘In this study,the multi-resolution Kalman filter(MKF)algorithm,which can handle multi-resolution problems with high computational efficiency,was used to blend two emissivity products:the Global LAnd Surface Satellite(GLASS)(BBE)product and the Advanced Spaceborne Thermal Emission and Reflection Radiometer(ASTER)narrowband emissivity(NBE)product.The ASTER NBE product was first converted into a BBE product.A new detrending method was used to transfer the BBEs into a process suitable for the MKF.The new detrending method was superior to the two existing methods.Finally,both the de-trended GLASS and ASTER BBE products were incorporated into the MKF framework to obtain the optimal estimation at each scale.Field measurements collected in North America were used to validate the integrated BBEs.Visually,the fusion map showed good continuity,with the exception of the border areas,and the quality of the fusion map was better than that of the original maps.The validation results indicate that the MKF improved the BBE product accuracy at the coarse scale.In addition,the MKF was capable of recovering missing pixels at a finer scale. | Linpeng Shi Shunlin Liang Jie Cheng Quan Zhang | 2016 | International Journal of Digital Earth2016，9，11： | 0 |
| 11 | Hepatic venous pressure gradient measurement guiding nonselective beta-blocker therapy in a patient with clinically significant portal hypertension显示文摘Clinically significant portal hypertension(CSPH),defined as a hepatic venous pressure gradient(HVPG)≥10 mmHg,is an independent risk factor for decompensated events in patients with compensated cirrhosis.Currently,the Baveno VII consensus recommends using nonselective beta-blockers to treat compensated cirrhosis in patients with CSPH.Here,we report a unusual case of compensated cirrhosis with CSPH caused by hepatitis B,and we successfully adjust NSBBs drug treatment strategies monitoring by HVPG results and achieve response standards.Timely adjustment of NSBBs drug treatment strategies based on HVPG test results for patients with CSPH can improve the final response rate. | Kun Wang Minghui Tian Linpeng Zhang Shanghao Liu Xiaoqing Guo Jianzhong Ma | 2023 | Portal Hypertension & Cirrhosis2023，2，2： | 0 |
| 12 | Combining biological denitrification and electricity generation in methane-powered microbial fuel cells显示文摘Methane has been demonstrated to be a feasible substrate for electricity generation in microbial fuel cells(MFCs)and denitrifying anaerobic methane oxidation(DAMO).However,these two processes were evaluated separately in previous studies and it has remained unknown whether methane is able to simultaneously drive these processes.Here we investigated the co-occurrence and performance of these two processes in the anodic chamber of MFCs.The results showed that methane successfully fueled both electrogenesis and denitrification.Importantly,the maximum nitrate removal rate was significantly enhanced from(1.4±0.8)to(18.4±1.2)mg N/(L·day)by an electrogenic process.In the presence of DAMO,the MFCs achieved a maximum voltage of 610 mV and a maximum power density of 143±12 mW/m^(2).Electrochemical analyses demonstrated that some redox substances(e.g.riboflavin)were likely involved in electrogenesis and also in the denitrification process.High-throughput sequencing indicated that the methanogen Methanobacterium,a close relative of Methanobacterium espanolae,catalyzed methane oxidation and cooperated with both exoelectrogens and denitrifiers(e.g.,Azoarcus).This work provides an effective strategy for improving DAMO in methane-powered MFCs,and suggests that methanogens and denitrifiers may jointly be able to provide an alternative to archaeal DAMO for methane-dependent denitrification. | Linpeng Yu Eryi Zhang Lin Yang Shiqi Liu Christopher Rensing Shungui Zhou | 2023 | Journal of Environmental Sciences2023，，8： | 0 |
| 13 | Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis(CHESS1904):An international multicenter study显示文摘Aim:To determine the tolerance and acceptance of hepatic venous pressure gradient(HVPG)measurements in patients with liver cirrhosis.Methods:This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG measurement between October 2019 and June 2020.Data related to the tolerance and acceptance of HVPG measurements were collected using descriptive questionnaires.Results:HVPG measurements were technically successful in all 271 patients,with 141(52.0%)undergoing HVPG measurement alone.The complication rate was 0.4%.Postoperative pain was significantly lower than preoperative expected pain(p<0.001)and intraoperative pain(p<0.001),and intraoperative pain was also significantly lower than preoperative expected pain(p=0.036).No,mild,moderate,severe,and intolerable discomfort scores were reported by 36.9%,44.6%,11.1%,6.3%,and 0.4%of these patients,respectively,during HVPG measurement and by 54.6%32.5%,11.4%,1.5%,and 0%,respectively,after HVPG measurement.Of these patients,39.5%had little understanding and 10%had no understanding of the value of HVPG measurement,with 35.1%and 4.1%regarding HVPG measurements as being of little or no help,respectively.Most patients reported that they would definitely(15.5%),probably(46.9%),or possibly(29.9%)choose to undergo additional HVPG measurements again,and 62.7%regarded the cost of the procedure as acceptable.Conclusion:HVPG measurement was safe and well‐tolerated in patients with cirrhosis,but patient education and communication are warranted to improve the acceptance of this procedure. | Jun‐Hui Sun He Zhao Haijun Zhang Lei Li NecatiÖrmeci Zi‐Niu Yu Xun Li Shuangxi Li Xujun Yang Huaping Wei Xiaoliang Zhu Zhengcong Zhang Yajin Wang Zhongwei Zhao Jianting Mao Qiaohong Wu Xiaole Sun Huiling Xiang Kefeng Jia Chao Yang Wei Wu Xiuqing Lin Haixin Yao Changzeng Zuo Jitao Wang Bo Zhang Chunqing Zhang Xiaoling Wu Guangchuan Wang Shengjuan Yao Ruihang Wang Li Zhou Hui Huan Qingli Tu Xue Pu Feng Zhang Qin Yin Linpeng Zhang Ying Guo Jian Wang Kohei Kotani Sawako Uchida‐Kobayashi Norifumi Kawada He Zhu Li Li Wei Wang Guo Zhang Lei Yu Xudong Cui Qingliang Zhu Hailong Zhang Xiaoli Hu Rafael OXimenes Adriano Gonçalves de Araújo Giulliano Gardenghi Yubao Zheng Zebin Wu Mingsheng Huang Xiaoyong Chen Jun Wu Feng Xie Yang Bo Shengjuan Hu Linke Ma Xiao Li Xiaolong Qi | 2022 | Portal Hypertension & Cirrhosis2022，1，1： | 0 |
| 14 | Vibrational Receptor of Scorpion(Heterometrus petersii):The Basitarsal Compound Slit Sensilla显示文摘Recently,micro-vibrational perception mechanisms of nocturnal arthropods such as scorpions and spiders are attracting increasingly more attention and research.The relevant micro-vibrational receptors are exquisite,in terms of their comprehensive performance such as sensitivity,stability,high anti-interference,and ultralow-power consumption.In this work,we find the Basitarsal Compound Slit Sensilla (BCSS) of scorpion (Heterometrus petersii) are composed of the crack-shaped slits as mechanosensory structure and can efficiently detect substrate-borne vibrational signal in complex natural environment.The study on microstructures and mechanical properties of tissue phases constituting the BCSS reveals that the strategy of tessellation is used to make crack-shaped slit amplify the tiny mechanical signal.In addition,the magnitude-frequency characteristics of electrophysiological signals caused by vibration stimulation with different frequencies indicate that the scorpion is sensitive to micro-vibrational signals at a certain frequency range.Meanwhile,the vibrational perception mechanism based on geometrical amplification and resonance is proposed to explain how scorpions detect the tiny biotic vibrational signal efficiently in noise environment.This finding not only promotes our further understanding of ultra-sensitive mechanism of the vibrational receptors,but also provides biological inspiration for the next generation of mechanosensor for a broad range of applications. | Kejun Wang Junqiu Zhang Linpeng Liu Daobing Chen Honglie Song Yinliang Wang Shichao Niu Zhiwu Han Luquan Ren | 2019 | Journal of Bionic Engineering2019，16，1： | 0 |
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