|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Facile one-pot sonochemical synthesis of hydrophilic ultrasmall LaF_3:Ce,Tb nanoparticles with green luminescence | Lisha Zhang a,Wei Li b,Xianghua Hu b,Yanlin Peng b,Junqing Hu b,Xingyu Kuang b,Linlin Song b,Zhigang Chen b a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Environmental Science and Engineering,Donghua University,Shanghai 201620,China b College of Materials Science and Engineering,Donghua University,Shanghai 201620,China | 2012 | Progress in Natural Science:Materials International2012，22，5： | 1 |
| 2 | Phylogenetic Analysis Revealed Concurrent Circulation of Two Clusters of Duck Tembusu Virus in South China显示文摘Eleven strains of duck Tembusu virus(TMUV)were isolated from diseased ducks at different duck farms in South China during 2011–2015,and their whole genomes were sequenced.The 11 isolated strains shared high sequence identity from 95.9%to 99.5%.Phylogenetic analysis revealed that all TMUV strains isolated after 2010 are clustered into two distinct branches,one branch comprising 2 Malaysian strains,and the other branch comprising all Chinese and Thai strains forming Chinese cluster 1 and Chinese cluster 2.Five of the 11 isolated strains were closely related to classical Chinese strains(BYD)belonging to Chinese cluster 1,and the remaining 6 isolated strains were closely related to strains newly isolated in South China and Thailand,belonging to Chinese cluster 2(a mixed China-Thailand cluster).Phylogenetic analysis of the partial E and NS 5 gene of TMUVs also showed the similar results.The results collectively showed a new trend of TMUV disease that two Chinese clusters of TMUV have been concurrently circulating in South China.This study provides practical guidance for preparing vaccines against TMUV in South China. | Linlin LI Jiawen DONG Chunhong ZHANG Ruihuan KUANG Minhua SUN Jianfeng ZHANG | 2019 | Agricultural Biotechnology2019，8，4： | 0 |
| 3 | Multi-valent mRNA vaccines against monkeypox enveloped or mature viron surface antigens demonstrate robust immune response and neutralizing activity显示文摘Monkeypox was declared a global health emergency by the World Health Organization,and as of March 2023,86,000 confirmed cases and 111 deaths across 110 countries have been reported.Its causal agent,monkeypox virus(MPV)belongs to a large family of double-stranded DNA viruses,Orthopoxviridae,that also includes vaccinia virus(VACV)and others.MPV produces two distinct forms of viral particles during its replication cycles:the enveloped viron(EV)that is released via exocytosis,and the mature viron(MV)that is discharged through lysis of host cells.This study was designed to develop multi-valent m RNA vaccines against monkeypox EV and MV surface proteins,and examine their efficacy and mechanism of action.Four m RNA vaccines were produced with different combinations of surface proteins from EV(A35R and B6R),MV(A29L,E8L,H3L and M1R),or EV and MV,and were administered in Balb/c mice to assess their immunogenicity potentials.A dynamic immune response was observed as soon as seven days after initial immunization,while a strong Ig G response to all immunogens was detected with ELISA after two vaccinations.The higher number of immunogens contributed to a more robust total Ig G response and correlating neutralizing activity against VACV,indicating the additive potential of each immunogen in generating immune response and nullifying VACV infection.Further,the m RNA vaccines elicited an antigen-specific CD4^(+)T cell response that is biased towards Th1.The m RNA vaccines with different combinations of EVand MV surface antigens protected a mouse model from a lethal dose VACV challenge,with the EV and MV antigens-combined vaccine offering the strongest protection.These findings provide insight into the protective mechanism of multi-valent m RNAvaccines against MPV,and also the foundation for further development of effective and safe m RNA vaccines for enhanced protection against monkeypox virus outbreak. | Niubing Zhang Xiang Cheng Yilong Zhu Ouyang Mo Huiqing Yu Liqi Zhu Juan Zhang Linlin Kuang Ying Gao Ruiyuan Cao Xiaozhen Liang Haikun Wang Honglin Li Song Li Wu Zhong Xuan Li Xiao Li Pei Hao | 2023 | Science China(Life Sciences)2023，66，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员