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您的检索式：作者名="Linjia BAI"
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| 1 | Collapse fragility assessment of steel roof framings with force limiting devices under transient wind loading显示文摘Steel structural frame is a popular structural form to cover large-span roof space and under high winds.Either part of the roof enclosure or the entire roof structure can be lifted off a building,particularly for low sloped roofs subject to wind-induced suction force.Collapse of roof could cause severe economic loss and poses safety risk to residents in the building.The buckling of members in a steel roof frame structure,which may lead to progressive collapse,may be dynamic in nature.This paper presents a fragility analysis of the collapse of steel roof frame structures under combined static and transient wind loading.Uncertainties associated with wind load change rate and member imperfections are taken into account in this study.A numerical example based on a Steel Joist Institute(SJI)K series joist was used to demonstrate the use of force limiting devices for collapse risk mitigation.For the presented fragility assessment of steel roof collapse,a Monte Carlo method combined with response surface approach was adopted,which greatly reduces the computation time and makes the Monte Carlo simulation feasible for probabilistic collapse analysis of steel roof frame structures. | Linjia BAI Yunfeng ZHANG | 2012 | Frontiers of Structural and Civil Engineering2012，6，3： | 2 |
| 2 | SERS monitoring of photoinduced-enhanced oxidative stress amplifier on Au@carbon dots for tumor catalytic therapy显示文摘Currently,artificial enzymes-based photodynamic therapy(PDT)is attractive due to its efficient capacity to change the immunosuppressive tumor microenvironment(TME).It is of great significance to study the therapeutic mechanism of novel artificial enzymes in TME through a monitoring strategy and improve the therapeutic effect.In this study,Au@carbon dots(Au@CDs)nanohybrids with a core-shell structure are synthesized,which not only exhibit tunable enzyme-mimicking activity under near-infrared(NIR)light,but also excellent surface-enhanced Raman scattering(SERS)properties.Therefore,Au@CDs show a good capability for monitoring NIR-photoinduced peroxidase-like catalytic processes via a SERS strategy in tumor.Moreover,the Au@CDs deplete glutathione with the cascade catalyzed reactions,thus elevating intratumor oxidative stress amplifying the reactive oxygen species damage based on the NIR-photoinduced enhanced peroxidase and glutathione oxidase-like activities,showing excellent and fast PDT therapeutic effect promoted by photothermal property in 3 min,finally leading to apoptosis in cancer cells.Through SERS monitoring,it is further found that after removing the NIR light source for 33 min,the reactive oxygen species(ROS)activity of the TME is counteracted and eliminated due to the presence of glutathione.This work presents a guidance to rationally design of artificial enzyme for ROS-involved therapeutic strategies and a new spectroscopic tool to evaluate the tumor catalytic therapy. | Linjia Li Jin Yang Jiahui Wei Chunhuan Jiang Zhuo Liu Bai Yang Bing Zhao Wei Song | 2022 | Light(Science & Applications)2022，11，10： | 0 |
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