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| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | Reversible adhesion surface coating proppant显示文摘Proppant is a key material in the hydraulic fracturing process,which has been widely used in unconventional oil exploitation.Normal proppants are easy to sedimentate and accumulate at the entrance of shale fracture,which will block the diversion of water,oil and gas.Coated proppants(CPs) are fabricated by coating resin on normal ceramic proppants through a simple method,which is dramatically enhanced the supporting properties in shale fracture and easy to scale up.Compared with uncoated ceramic proppants,the self-suspension ability of CPs is ~11 times higher,which are able to migrate and distribute farther and deeper inside the fracture.At the same time,Coating enhanced the 23.7% of adhesive force in maximum,which makes the CPs easier to adhere on the fracture surface to supportthe shale fracture.Besides,the liquid conductivity of CPs is 60% higher than uncoated ceramic proppants at13.6 MPa pressure.This method is expected to fabricated varieties of proppantsfor shale fracture supporting to improve the exploration of unconventional oil and gas resources. | Quan Xu Fan Fan Zhaohui Lu Mao Sheng Shouceng Tian Ye Zhang Linhua Pan Yang Zhou | 2021 | Chinese Chemical Letters2021，32，1： | 2 |
| 3 | Electrolytic manganese metal industry experience based China’s new model for cleaner production promotion显示文摘 | Ning Duan Zhigang Dan Fan Wang Cenxuan Pan Changbo Zhou Linhua Jiang | 2011 | Journal of Cleaner Production2011，，17： | 2 |
| 4 | Solvent extraction of rhodium from aqueousy solution of Rh(Ⅲ)-Sn(Ⅱ)-Cl-system by TBP显示文摘 | Zou Linhua Chen Jing Pan Xuejun | 1998 | Hydrometallurgy1998，50，： | 1 |
| 5 | Solvent extraction of rhodium from aqueous solution of Rh ( Ⅲ ) - Sn( Ⅱ) - Cl - system by TBP 显示文摘 | ZOU Linhua CHEN Jing PAN Xuejun | 1998 | Hydrometallurgy1998，50，3： | 1 |
| 6 | Solvent extraction of rhodium from aqueous solution of Rh(Ⅲ)-Sn(Ⅱ)-Cl- system by TBP 显示文摘 | Chen Jing Pan Xuejun | 1998 | Hydrometallurgy1998，50，： | 1 |
| 7 | Preliminary study of the internal margin of the gross tumor volume in thoracic esophageal cancer显示文摘 | Jiancheng Li Linhua Wang Xiaoliang Wang Yunhui Zhao Di Liu Cheng Chen He Ping Zhang Jianji Pan | 2012 | Cancer / Radiothérapie2012，，7： | 1 |
| 8 | Corrosion Resistance of Steel in Cracked Reinforced Concrete after Electro-depositon Treatment显示文摘An electro-deposition method has been recently proposed to repair cracked reinforced concrete. To evaluate the corrosion resistance of the reinforcing steel in cracked concrete, three different parameters including type of auxiliary electrode, electrode distance, and current density were studied. Tafel polarization curve was used to evaluate the corrosion resistance of the steel. Self-corrosion potential and corrosion current of the steel were tested. The results indicate that the corrosion resistance improvement of the reinforcing steel is optimal as prism titanium mesh is applied as auxiliary electrode, followed by the flaky titanium mesh and the column titanium bar. When the electrode distance is 60 mm, the corrosion resistance improvement of the reinforcing steel is optimal, and with 80 mm electrode distance, the corrosion resistance improvement is the poorest. The property falls in between them when 40 mm electrode distance is used. Moreover, the corrosion resistance improvement of the reinforcing steel increases as the current density goes up. | 储洪强 PAN Congling XIONG Chuansheng ZHAO Sujing JIN Ming SONG Zijian JIANG Linhua | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，5： | 0 |
| 9 | Indoor Toxicity and Field Efficacy of Five Insecticides against Cerataphis lataniae Biosduval显示文摘[Objective] The paper aimed to screen out efficient and safe insecticides against Cerataphis lataniae Biosduval. [Method] Control effects of five insecticides against C. lataniae were studied through indoor bioassay and field trial. [Result] Bioassay results showed that the indoor toxicities of 10% α-cypermethrin,22% sulfoxaflor and 10% imidacloprid were higher,with LC 50 of 15.28,30.00 and 30.23 mg/L,respectively. In field trials,the control effects of 10% α-cypermethrin,22% sulfoxaflor and 10% imidacloprid against C. lataniae were over 90% for all the concentrations at 10 d post adminstration. The control effect of 22% sulfoxaflor reached 100% for all the concentrations at 5 d post administration. [Conclusion]10% α-cypermethrin was a superior pesticide against C. lataniae,but 22% sulfoxaflor and 10% imidacloprid were more efficient in emergency. | Sha Linhua Chen Lin Chen Pan Xu Jianhui Luo Xiangyue | 2016 | Plant Diseases and Pests2016，7，1： | 0 |
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