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| 1 | Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications显示文摘Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer treatment, but the complex biological processes of cancer cells seriously limit the efficacy of various anticancer drugs. Autophagy, a self-degradative system that maintains cellular homeostasis, universally operates under normal and stress conditions in cancer cells. The roles of autophagy in cancer treatment are still controversial because both stimulation and inhibition of autophagy have been reported to enhance the effects of anticancer drugs. Thus, the important question arises as to whether we should try to strengthen or suppress autophagy during cancer therapy. Currently, autophagy can be divided into four main forms according to its different functions during cancer treatment: cytoprotective(cell survival), cytotoxic(cell death), cytostatic(growth arrest), and nonprotective(no contribution to cell death or survival). In addition, various cell death modes, such as apoptosis, necrosis, ferroptosis, senescence, and mitotic catastrophe, all contribute to the anticancer effects of drugs. The interaction between autophagy and these cell death modes is complex and can lead to anticancer drugs having different or even completely opposite effects on treatment. Therefore, it is important to understand the underlying contexts in which autophagy inhibition or activation will be beneficial or detrimental.That is, appropriate therapeutic strategies should be adopted in light of the different functions of autophagy. This review provides an overview of recent insights into the evolving relationship between autophagy and cancer treatment. | Zhaoshi BAI Yaling PENG Xinyue YE Zhixian LIU Yupeng LI Lingman MA | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，2： | 5 |
| 2 | Uterine artery score and perinatal outcome显示文摘 | Hernandez Andrade E Brodszk i J Lingman G | 2002 | Utrasound Obstet Gynecol2002，19，4： | 1 |
| 3 | The impact of hypertension and diabetes on outcome in patients undergoing percutaneous coro- nary intervention 显示文摘 | Lingman M Albertsson P Herlitz J | 2011 | Am J Med2011，124，： | 1 |
| 4 | comparison of results of perautaneous nephrostolithatomy and extracpreal shock wave tithotripsy 显示文摘 | Lingman J E Coury A Newman 0 M | 1997 | Urdogy1997，138，： | 1 |
| 5 | Morphology of the Pelvic Floor显示文摘 | Hugosson C Jorulf H Lingman G | 1991 | Lancet1991，337，8737： | 1 |
| 6 | A critical appraisal of the use of umbilical artery Doppler ultrasound in high-risk pregnancies:use of meta-analyses in evidence-based obstetrics显示文摘 | Westergaard HB Langhoff-Roos J Lingman G | | 0，，6： | 1 |
| 7 | Changes in human fetal oxygenation during maternal hyperoxia as estimated by BOLD MRI显示文摘 | Anne S?rensen David Peters Carsten Simonsen Michael Pedersen Brian Stausb?l‐Gr?n Ole Bjarne Christiansen G?ran Lingman Niels Uldbjerg | 2012 | Prenat Diagn2012，，2： | 1 |
| 8 | Uterine artery score and perinatal outcome显示文摘 | Hemandez - Andrade E Brodszki J Lingman G | | Ultrasound Obstet Gyne- eol0，19，5： | 1 |
| 9 | Transient repolarization alterations dominate the initial phase of an acute anterior infarc- tion--a vectorcardiography study 显示文摘 | Lingman M Hartford M Karlsson T | 2014 | Electrocardio12014，47，4： | 1 |
| 10 | Transient repo- larization alterations dominate the initial phase of an acute anterior infarction-a vectorcardiography study显示文摘 | Lingman M Hartford M Karlsson T | 2014 | J Elec- trocardiol2014，47，4： | 1 |
| 11 | Three methods for hysterectomy: a randomized prospective study of short term outcome显示文摘 | Ottosen C Lingman G Ottosen L | 2000 | Br J Obstet Gynaecol2000，107，11： | 1 |
| 12 | AUA guide- line on management of staghorn calculi:Diagnosis and treatment recommendations显示文摘 | Preminger GM Assimos DG Lingman JE | 2005 | J Urol2005，173，6： | 1 |
| 13 | Uterine artery score and perinatal outcome显示文摘 | Hernandez-Andrade E BrodszkiJ Lingman G | 2002 | Utrasound Obstet Gynecol2002，19，5： | 1 |
| 14 | Circulatory effects of fetal arrhythmias显示文摘 | Lingman G Marsal K | 1996 | Pediatrtic Cardiogy1996，7，： | 1 |
| 15 | Transvaginal ultrasound and lactate dehydrogenase isoenzyme activity profile in uterine aspirate for diagnosis of endometrial carcinoma in women with postmenopausal bleeding显示文摘 | Niklasson O Skude G Lingman G | 2007 | Int J Gynecol Cancer2007，17，6： | 1 |
| 16 | The Effectiveness of Rear Axle Steering on the Yaw Stability and Responsive- ness of a Heavy Truck 显示文摘 | Kharrazi S Lidberg M Lingman P | 2008 | Vehicle System Dynamics2008，，： | 1 |
| 17 | A critical appraisal of the use of umbilical artery Doppler ultrasound in high-risk pregnancies: use of meta-analyses in evidence-based obstetrics显示文摘 | Westergaard HB Langhoff-Roos J Lingman G | 2001 | Ultrasound Obstet Gynecol2001，17，6： | 1 |
| 18 | Morphology of the pelvic floor显示文摘 | Hugosson C Jorulf H Lingman G | 1991 | Lancet1991，337，： | 1 |
| 19 | Uterine artery score and perinatal outcome显示文摘 | Hernandez-Andrade E Brodszki J Lingman G | 2002 | Ultrasound Obstet Gyneeol2002，19，5： | 1 |
| 20 | AUA guideline on management of staghorn calculi: diagnosis and treatment recommendations显示文摘 | Preminger GM Assimos DG Lingman JE | 1991 | J Urol1991，200，173： | 1 |
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