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| 1 | Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management显示文摘Chronic hepatitis B(CHB) is a major global health problem affecting an estimated 350 million people with more than 786000 individuals dying annually due to complications, such as cirrhosis, liver failure and hepatocellular carcinoma(HCC). Liver transplantation(LT) is considered gold standard for treatment of hepatitis B virus(HBV)-related liver failure and HCC. However, post-transplant viral reactivation can be detrimental to allograft function, leading to poor survival. Prophylaxis with high-dose hepatitis B immunoglobulin(HBIG) and anti-viral drugs have achieved remarkable progress in LT by suppressingviral replication and improving long-term survival. The combination of lamivudine(LAM) plus HBIG has been for many years the most widely used. However, life-long HBIG use is both cumbersome and costly, whereas long-term use of LAM results in resistant virus. Recently, in an effort to develop HBIG-free protocols, high potency nucleos(t)ide analogues, such as Entecavir or Tenofovir, have been tried either as monotherapy or in combination with low-dose HBIG with excellent results. Current focus is on novel antiviral targets, especially for covalently closed circular DNA(ccc DNA), in an effort to eradicate HBV infection instead of viral suppression. However, there are several other molecular mechanisms through which HBV may reactivate and need equal attention. The purpose of this review is to address post-LT HBV reactivation, its risk factors, underlying molecular mechanisms, and recent advancements and future of anti-viral therapy. | Ranjit Chauhan Shilpa Lingala Chiranjeevi Gadiparthi Nivedita Lahiri Smruti R Mohanty Jian Wu Tomasz I Michalak Sanjaya K Satapathy | 2018 | World Journal of Hepatology2018，10，3： | 5 |
| 2 | Immunohistochemical staining of cancer stem cell markers in hepatocellular carcinoma 显示文摘 | Lingala S Cui YY Chen X | 2010 | ExpMolPathol2010，89，1： | 1 |
| 3 | Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations 显示文摘 | Chen X Lingala S Khoobyari S | 2011 | J Hepatol2011，55，4： | 1 |
| 4 | Declines in mortality from acute myocardial infarction in successive incidence and birth cohorts of patients with rheumatoid arthritis显示文摘 | Krishnan E Lingala VB Singh G | 2004 | Circulation2004，110，13： | 1 |
| 5 | Hyperuricemia and untreated gout are poor prognostic marker among those with a recent acute myocardial infarction显示文摘 | Krishnan E Pandya BJ Lingala B | 2012 | Arthritis Res Ther2012，14，1： | 1 |
| 6 | Epithelial mesen- chymal transition and hedgehog signaling activation are as- sociated with chemoresistance and invasion of hepatoma subpopulations显示文摘 | Chen X Lingala S Khoobyari S | 2011 | J Hepatol2011，55，： | 1 |
| 7 | Immunohistochemical staining of cancer stem cell markers in hepatocellular carcinoma显示文摘 | Lingala S Cui Y Y Chert X | | 0，，01： | 1 |
| 8 | Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis 显示文摘 | Wasko MC Hubert HB Lingala VB | 2007 | JAMA2007，298，2： | 1 |
| 9 | Hyperuricemia anduntreated gout are poor prognostic markers among those with a re-cent acute myocardial infarction显示文摘 | Krishnan E Pandya BJ Lingala B | 2012 | Arthritis Res Ther2012，14，1： | 1 |
| 10 | Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations显示文摘 | Chen X Lingala S Khoobyari S | 2011 | J Hepato12011，55，4： | 1 |
| 11 | Blind compressive sensing dynamic MRI 显示文摘 | Lingala SG Jacob M | 2013 | IEEE Tran Med Imaging2013，32，6： | 1 |
| 12 | Accelerated dynamic MRI exploiting sparsity and low-rank structure: k-t SLR显示文摘 | Lingala SG Hu '2 Dibella E | 2011 | IEEE Trans Med Imaging2011，30，5： | 1 |
| 13 | Assessment of packed bed bioreaetor systems in the production of viral vaccines显示文摘 | RAJENDRAN R LINGALA R VUPPU S K | 2014 | AMBExpress2014，4，： | 1 |
| 14 | Hyperuricemia and untreated gout are poor prognostic markers among those with a recent acute myocardial infarction显示文摘 | Krishnan E Pandya B J Lingala B | 2012 | Arthritis Res Ther2012，14，1： | 1 |
| 15 | Hydroxychloroquine andrisk of diabetes in patients with rheumatoid arthritis显示文摘 | Wasko MC Hubert HB Lingala VB | 2007 | JAM&2007，298，2： | 1 |
| 16 | Declines in mortality from acutemyocardial infarction in successive incidence and birth cohorts of patients with rheumatoid arthritis 显示文摘 | Krishnan E Lingala VB Singh G | 2004 | Circulation2004，110，13： | 1 |
| 17 | Immunohistochemical staining of cancer stem cell markers in hepatocellular carcinoma显示文摘 | Lingala S Cui YY Chen X | 2010 | Exp Mol Pathol2010，89，1： | 1 |
| 18 | Blind Compressive Sensing Dynamic MRI 显示文摘 | Lingala S Jacob M | 2013 | Medical Imaging IEEE Transactions on Medical Imaging2013，32，6： | 1 |
| 19 | Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations显示文摘 | Chen X Lingala S Khoobyari S | 2011 | J Hepatol2011，55，4： | 1 |
| 20 | Hyperuricemia and untreated gout are poor prognostic markers among those with a recent acute myocardial infarction显示文摘 | Krishnan E Pandya BJ Lingala B | 2012 | Arthritis Res Ther2012，14，1： | 1 |
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