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您的检索式：作者名="Linfei Feng"
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| 1 | Knockdown of Nav1_5 inhibits cell proliferation,migration and invasion via Wnt/β-catenin signaling pathway in oral squamous cell carcinoma显示文摘Oral squamous cell carcinoma(OSCC)is a common type of malignant oral cancer that has a high recurrence rate.Voltage-gated sodium channel Nav1.5 was reported to be highly up-regulated in various types of cancers.However,the regulatory mechanism of Nav1.5 in cancers including OSCC still remains elusive.In this study,Nav1.5 was found to be highly expressed in OSCC tissues and cells.Through the analysis of clinical characteristics of patients,we found that the expression level of Nav1.5 was closely related to neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,tumor-node-metastasis stage,and lymph node metastasis.Moreover,we found that Nav1.5 mainly located on the cell membrane as well as cytoplasm and knockdown of Nav1.5 promoted cell apoptosis and decreased proliferation in OSCC.Transwell assay results showed that knockdown of Nav1.5 effectively suppressed the migration and invasion in OSCC.In addition,knockdown of Nav1.5 was found to inhibit the protein and mRNA expression levels ofβ-catenin,cyclin D1,and C-Myc in the Wnt/βcatenin signaling pathway.In summary,these results indicated that Nav1.5 may be involved in the progression of OSCC through the Wnt/βcatenin signaling pathway. | Xiaoli Xu Yongzheng Dai Linfei Feng Hongli Zhang Yukun Hu Le Xu Xinwei Zhu Yong Jiang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 0 |
| 2 | The Association between Vitamin D and Hashimoto Thyroiditis:An Upto-date Systematic Review and Meta-analysis显示文摘The objective of the surrent study was to summarize the up-to-date studies to investigate the relationship between vitamin D and Hashimoto thyroiditis(HT).An online search of English and Chinese databases was performed.The studies concerned the investigation of the relationship between vitamin D and HT including meta-analysis,meanwhile the heterogeneities were revealed by subgroup analysis.Fourty six elated studies containing 15,336 participants(HT:6,138 versus control:9,198)were included.HT patients had lower levels of 25(OH)D_(3)(standardised mean difference,−1.09;95%CI:[−1.42,−0.75];P<0.01),and were more likely to be deficient in 25(OH)D_(3)(OR,2.77;95%CI,[1.88,3.91];P<0.05).Obvious heterogeneities in the results of meta-analysis were down to the difference of detection methods and criteria of vitamin D insufficiency among studies.Vitamin D deficiency was colncluded to have a significant relation with HT. | Zhengrong Liu Linfei Feng Yanfang He Sijie Yuan Chao Xu | 2022 | Food Materials Research2022，2，1： | 0 |
| 3 | A laser synthesis of vanadium oxide bonded graphene for high-rate supercapacitors显示文摘Graphene is a type of promising electrode material for high-energy and high-power density supercapacitors,but its electrochemical performance is greatly limited by the restacking problem.In this work,we reported a facile approach to synthesis graphene with chemically bonded vanadium oxide(VOx)nanoparticles and demonstrated that chemically-bonded VOxnanoparticles can effectively prevent the graphene sheets from restacking and hence improve the electrochemical performance.The capacitance of VOxbonded graphene increases to 272 F/g compared to 183 F/g of pristine graphene in 1 M H3PO4 aqueous electrolyte at 2 A/g.The VOx-bonded graphene also showed improved rate capability in both H3PO4 and ionic liquid electrolytes.The capacitance retention increases to 54.5%from 28.5%at 100 A/g(compare to2 A/g)in H3PO4 and increases to 65.1%from 46.3%at 2 A/g(compare to 0.2 A/g)in neat ionic liquid.A high energy density of 84.4 Wh/kg is obtained within the voltage window of 4 V in ionic liquid.Even at a high-power density of 1000 W/kg,the VOx-bonded graphene shows a high energy density of 47.3 Wh/kg. | Jun Tang Linfei Zhang Xiongwei Zhong Xinghui Wang Feng Pan Baomin Xu | 2020 | Journal of Energy Chemistry2020，29，10： | 0 |
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