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您的检索式：作者名="Lin Xuanhao"
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| 1 | 显示文摘 | Liu Zhaolin Lin Xuanhao Lee Jim Yattg | 2002 | Langmuir2002，18，10： | 1 |
| 2 | Preparation and characterization of platinum-based electrocatalysts on multiwalled carbon nanotubes for proton exchange membrane fuel cells 显示文摘 | Liu Zhaolin Lin Xuanhao Lee Jim Yang Zhang Weide Hart Ming Gan Leong Ming | 2002 | Langmuir2002，18，10： | 1 |
| 3 | A Review on Electrospinning as Versatile Supports for Diverse Nanofibers and Their Applications in Environmental Sensing显示文摘Rapid industrialization is accompanied by the deterioration of the natural environment.The deepening crisis associated with the ecological environment has garnered widespread attention toward strengthening environmental monitoring and protection.Environmental sensors are one of the key technologies for environmental monitoring,ultimately enabling environmental protection.In recent decades,micro/nanomaterials have been widely studied and applied in environmental sensing owing to their unique dimensional properties.Electrospinning has been developed and adopted as a facile,quick,and effective technology to produce continuous micro-and nanofiber materials.The technology has advanced rapidly and become one of the hotspots in the field of nanomaterials research.Environmental sensors made from electrospun nanofibers possess many advantages,such as having a porous structure and high specific surface area,which effectively improve their performance in environmental sensing.Furthermore,by introducing functional nanomaterials(carbon nanotubes,metal oxides,conjugated polymers,etc.)into electrospun fibers,synergistic effects between different materials can be utilized to improve the catalytic activity and sensitivity of the sensors.In this review,we aimed to outline the progress of research over the past decade on electrospinning nanofibers with different morphologies and functional characteristics in environmental sensors. | Jialing Song Xuanhao Lin Liang Ying Ee Sam Fong Yau Li Manhong Huang | 2023 | Advanced Fiber Materials2023，5，2： | 0 |
| 4 | AIFM1 variants associated with auditory neuropathy spectrum disorder cause apoptosis due to impaired apoptosis-inducing factor dimerization显示文摘Auditory neuropathy spectrum disorder(ANSD)represents a variety of sensorineural deafness conditions characterized by abnormal inner hair cells and/or auditory nerve function,but with the preservation of outer hair cell function.ANSD represents up to 15%of individuals with hearing impairments.Through mutation screening,bioinformatic analysis and expression studies,we have previously identified several apoptosis-inducing factor(AIF)mitochondria-associated 1(AIFM1)variants in ANSD families and in some other sporadic cases.Here,to elucidate the pathogenic mechanisms underlying each AIFM1 variant,we generated AIF-null cells using the clustered regularly interspersed short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system and constructed AIF-wild type(WT)and AIF-mutant(mut)(p.T260A,p.R422W,and p.R451Q)stable transfection cell lines.We then analyzed AIF structure,coenzyme-binding affinity,apoptosis,and other aspects.Results revealed that these variants resulted in impaired dimerization,compromising AIF function.The reduction reaction of AIF variants had proceeded slower than that of AIF-WT.The average levels of AIF dimerization in AIF variant cells were only 34.5%-49.7%of that of AIF-WT cells,resulting in caspase-independent apoptosis.The average percentage of apoptotic cells in the variants was 12.3%-17.9%,which was significantly higher than that(6.9%-7.4%)in controls.However,nicotinamide adenine dinucleotide(NADH)treatment promoted the reduction of apoptosis by rescuing AIF dimerization in AIF variant cells.Our findings show that the impairment of AIF dimerization by AIFM1 variants causes apoptosis contributing to ANSD,and introduce NADH as a potential drug for ANSD treatment.Our results help elucidate the mechanisms of ANSD and may lead to the provision of novel therapies. | YUE QIU HONGYANG WANG HUAYE PAN JING GUAN LEI YAN MINGJIE FAN HUI ZHOU XUANHAO ZHOU KAIWEN WU ZEXIAO JIA QIANQIAN ZHUANG ZHAOYING LEI MENGYAO LI XUE DING AIFU LIN YONG FU DONG ZHANG QIUJU WANG QINGFENG YAN | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 0 |
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