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| 1 | How do Chinese medicines that tonify the kidney inhibit dopaminergic neuron apoptosis?显示文摘Wistar rats were intragastrically perfused with Chinese medicines used for tonifying the kidney.These included 0.180 g/mL of Herba Epimedii(Epimedium), Semen Cuscutae(Dodder Seed), or Herba Cistanches(Desertliving Cistanche), 0.04 mg/mL monoamine oxidase-B inhibitor selegiline,or distilled water for 14 consecutive days to prepare drug-containing serum or blank serum.MES23.5 cells in the logarithmic phase were cultured in media supplemented with 15%drug-containing serum for 24 hours, followed by incubation in culture solution containing 100 μmol/L H2O2for 3 hours. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) and flow cytometry results showed that all drug-containing serums improved the survival rate of H2O2-injured MES23.5 cells, inhibited pro-apoptotic FasL and caspase-3 expression, promoted anti-apoptotic Bcl-2 expression. However, drug-containing serums had little influence on Fas expression in H2O2-injured MES23.5 cells. Enzyme-linked immunosorbent assay results showed that serum containing Herba Cistanches or Herba Epimedii increased the expression of nerve growth factor,brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in injured MES23.5cells; serum containing Semen Cuscutae only increased brain-derived neurotrophic factor expression; while expression of the above neurotrophic factors remained the same in cells treated with serum containing selegiline. These findings indicate that Chinese medicines used to tonify the kidney can protect nerve cells by regulating the expression of apoptosis-related factors and neurotrophic factors in MES23.5 cells. | Shaogang Lin Shuifen Ye Jinmu Huang Yun Tian Yihui Xu Mengqi Wu Jingxia Wang Songying Wu Jing Cai | 2013 | Neural Regeneration Research2013，8，30： | 9 |
| 2 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 3 | Unexpected complexity of multidrug resistance in the mcr-1-harbouring Escherichia coli显示文摘Dear Editor,The discovery that the mobile colistin resistance gene(mcr-1)is encoded by plasmids and is prevalent in food animals and human beings worldwide(Hasman et al.,2015;Liu et al.,2015)has challenged greatly our traditional idea that polymyxin(consisting of two isoforms:polymyxin B and polymyxin E(colistin))acts as an ultimate line of refuge in the clinical treatment against the severe infections by the multidrug-resistant Gram-negative pathogens(Nation et al.,2015;Paterson and Harris,2015).To make | Rongsui Gao Yue Li Jingxia Lin Chen Tan Youjun Feng | 2016 | Science China(Life Sciences)2016，59，7： | 5 |
| 4 | Diversified variants of the mcr-1-carrying plasmid reservoir in the swine lung microbiota显示文摘Dear Editor,Emergence of bacteria with multiple drug resistance is a major problem in global public health.Polymyxin comprising polymyxin E(colistin)and polymyxin B is generally recognized as the last-resort antibiotics with | Zhencui Li Chen Tan Jingxia Lin Youjun Feng | 2016 | Science China(Life Sciences)2016，59，9： | 3 |
| 5 | Adverbial Clauses显示文摘 | Lin Jingxia | 2015 | International Encyclopediaof the Social & Behavioral Sciences2015，，： | 1 |
| 6 | MeasureRbl,Re,Rgl in Ginsenoside of Shenxue Capsule显示文摘 | Wang Jingxia Chen Lin Qiao Qingshen | 2011 | Joumalof Zhejiang Chinese Medical University2011，，1： | 1 |
| 7 | Micellar Catalysis:Visible-Light Mediated Imidazo[1,2-a]pyridine C—H Amination with N-Aminopyridinium Salt Accelerated by Surfactant in Water显示文摘A light-promoted metal-free protocol for the amination of imidazo[1,2-a]pyridines with N-aminopyridinium salt by the assistance of surfactants in water was reported,charactering mild and environmentally benign conditions,as well as great functional group tolerance.Micelles with negatively charged polar surface and hydrophobic core formed from sodium dodecyl sulfate serve as an ideal medium for visible-light mediated radical reaction of cationic pyridine salt and imidazo[1,2-a]pyridine in aqueous phase.The electrostatic interaction between positively charged N-aminopyridinium and negatively charged surface of micelles is of great significance in this method. | Zhonglie Yang Kun Cao Xiaoyan Peng Li Lin Danchen Fan Jun-Long Li Jingxia Wang Xiaobin Zhang Hezhong Jiang Jiahong Li | 2021 | Chinese Journal of Chemistry2021，39，12： | 0 |
| 8 | Impacts of acupressure treatment on depression:A systematic review and meta-analysis显示文摘BACKGROUND Depression is recognized as a major public health problem with a substantial impact on individuals and society.Complementary therapies such as acupressure may be considered a safe and cost-effective treatment for people with depression.An increasing body of research has been undertaken to assess the effectiveness of acupressure in various populations with depression,but the evidence thus far is inconclusive.AIM To examine the efficacy of acupressure on depression.METHODS A systematic literature search was performed on PubMed,PsycINFO,Scopus,Embase,MEDLINE,and China National Knowledge(CNKI).Randomized clinical trials(RCTs)or single-group trials in which acupressure was compared with control methods or baseline in people with depression were included.Data were synthesized using a random-effects or a fixed-effects model to analyze the impacts of acupressure treatment on depression and anxiety in people with depression.The primary outcome measures were set for depression symptoms.Subgroups were created,and meta-regression analyses were performed to explore which factors are relevant to the greater or lesser effects of treating symptoms.RESULTS A total of 14 RCTs(1439 participants)were identified.Analysis of the betweengroup showed that acupressure was effective in reducing depression[Standardized mean differences(SMDs)=-0.58,95%CI:-0.85 to-0.32,P<0.0001]and anxiety(SMD=-0.67,95%Cl:-0.99 to-0.36,P<0.0001)in participants with mildto-moderate primary and secondary depression.Subgroup analyses suggested that acupressure significantly reduced depressive symptoms compared with different controlled conditions and in participants with different ages,clinical conditions,and duration of intervention.Adverse events,including hypotension,dizziness,palpitation,and headache,were reported in one study.CONCLUSION The evidence of acupressure for mild-to-moderate depressive symptoms was significant.Importantly,the findings should be interpreted with caution due to study limitations.Future research with a well-designed mixed method is required to consolidate the conclusion and provide an in-depth understanding of potential mechanisms underlying the effects. | Jingxia Lin Tianhao Chen Jiali He Raymond CK Chung Haixia Ma HWH Tsang | 2022 | World Journal of Psychiatry2022，12，1： | 0 |
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