|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 2 | 低剂量睾酮疗法降低TM3睾丸间质细胞的氧化损伤显示文摘睾酮替代疗法对老年男性及性腺机能减退症的治疗是有意义的。然而,外源性睾酮对睾丸间质细胞的作用尚不清楚,需要进一步阐明。本研究表明睾酮补充疗法能降低睾丸间质细胞的氧化损伤。本文用睾丸间质细胞TM3作为体外细胞模型。研究发现睾酮剂量为100nmol L-1治疗时可以产生细胞保护作用,但睾酮补充剂量≥500nmol L-1时就会产生细胞毒作用。在睾酮剂量为100nmol L-1治疗时能够显著降低ROS的产生,脂质过氧化物含量,缺氧诱导因子(HIF)-1α的稳定性和活性。睾酮剂量为500nmol L-1时产生的活性氧比100nmol L-1时增加了1.72倍。与对照组相比,睾酮剂量为50nmol L-1时类固醇激素合成急性调节蛋白(STAR)的表达增加了1.58倍(P〈0.01).睾酬补充疗法降低了化学性诱导缺氧。低剂量睾酮补充疗法治疗睾丸间质细胞通过降低ROS和脂质过氧化物,增加StAR蛋白表达,减缓缺氧应激即降低HIF-1α测子的稳定性性产生细胞保护作用。研究中发现当睾酮剂量≥500nmol L-1时,氧化损伤增加。为阐明睾酮替代疗法的效果,需进一步阐明睾丸间质细胞中华酮量效关系受哪种机制调控。 | Thomas IS Hwang Tien-Ling Liao Ji-Fan Lin Yi-Chia Lin Shu-Yu Lee Yen-Chun Lai Shu-Huei Kao | 2011 | Asian Journal of Andrology2011，13，3： | 2 |
| 3 | Congenital dacrypcystocelewith acute dacrypcystitis: report of two cases显示文摘 | Lin IS Nar MK Kua KE | 2006 | Acta PaediatrTaiwan2006，47，1： | 1 |
| 4 | Role of electrophysiological studies and arrhythmia intervention in repairing Ebstein' s anomaly显示文摘 | Huang CJ Chiu IS Lin FY | 2000 | Thorac Cardiovasc Surg2000，48，6： | 1 |
| 5 | Possible localization of a recessive testis forming gene on 9p24 显示文摘 | Hoo JJ Salafsky IS Lin CC | 1989 | Am J Hum Genet1989，45，： | 1 |
| 6 | Coumarins and anti- platelet aggregation constituents from Zanthoxylurn schinfolium 显示文摘 | Chen IS Lin YC Tsai IL | 1995 | Phytochemistry1995，39，5： | 1 |
| 7 | Long-term Beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection显示文摘 | Lin SM Sheen IS Chien RN | | HEPATOLOGY0，，： | 1 |
| 8 | Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B:a longitudinal study显示文摘 | Lin DY Sheen IS Chiu CT | 1993 | J Clin Ultrasound1993，21，5： | 1 |
| 9 | Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection显示文摘 | Lin SM Sheen IS Chien RN et at | 1999 | Hepatology1999，29，3： | 1 |
| 10 | Genome- wide hy- pomethylation in hepatocellular carcinogenesis 显示文摘 | Lin C H H sieh SY Sheen IS | 2001 | Cancer Res2001，61，10： | 1 |
| 11 | Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection显示文摘 | Lin SM Sheen IS Chien RN | 1999 | Hepatology1999，29，： | 1 |
| 12 | Genome-wide hypomethylation in hepatocellular carcinogenesis显示文摘 | Lin CH Hsieh SY Sheen IS | 2001 | Cancer Res2001，61，10： | 1 |
| 13 | Inoculation route - dependent and allergen - specific supressive effects of bacille calmette - guerin vaccination on asthmatic reaction in BALB/c mice 显示文摘 | Choi IS Lin XH Koh YA | 2007 | Lung2007，185，3： | 1 |
| 14 | Genome2 wide hypomethyla- tion in hepatocelular carcinogenesis 显示文摘 | Lin CH Hsieh SY Sheen IS | 2001 | Cancer Res2001，61，10： | 1 |
| 15 | Flavopiridol, fludarabine and rituximab ( FFR ) : an active regimen in indolent B - cell lymphoproliferative disorders and mantle cell lymphoma 显示文摘 | Lin 'IS Fischer B Btum KA | 2008 | Blood2008，112，： | 1 |
| 16 | Role of hepatitis C and delta viruses in the termination of chronic hepati- tis B surface antigen carrier state : a multivariate anal- ysis in a longitudinal follow-up study 显示文摘 | Sheen IS Liaw YF Lin DY | 1994 | J Infect Dis1994，170，2： | 1 |
| 17 | The functional outcome of lower-extremity fractures with vascular injury显示文摘 | Lin CH Wei FC Levin IS | 1997 | J Trauma1997，43，3： | 1 |
| 18 | Structure-function studies on Taiwan cobra long neurotoxin homolog显示文摘 | Chang IS Lin SR Wang J J | 2000 | Biochimica Biophysica Acta2000，1480，： | 1 |
| 19 | Amisulpride related tic -like symptoms in an adolescent schizophrenic 显示文摘 | Lin CL Shiah IS Yeh CB | 2006 | Proq Neropsycho- pharmacol Biol Psyehiatry2006，30，： | 1 |
| 20 | Erythema elevatum diutinum as a paraneoplastic syndrome in a patient with pulmonary lymphoepithelioma-like carcinoma 显示文摘 | Liu TC Chen IS Lin TK | 2009 | Lung Cancer2009，63，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员