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| 1 | Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection显示文摘AIM To demonstrate the relationship betweenH-ras oncogene and hepatocellular carcinoma(HCC) metastasis.METHODS Activated H-ras oncogene wastransfected into SMMC 7721, a cell line derivedfrom human HCC, by calcium phosphatetransfection method. Some metastasis-relatedparameters were detected in vitro, includingadhesion assay, migration assay, expression ofcollagenase ⅣV (c ⅣV ase) and epidermal growthfactor receptor (EGFR).RESULTS The abilities of H-ras-transfected cellclones in adhesion to laminin (LN) or fibronectin(FN), migration, c Ⅳ ase secretion increasedmarkedly, and the expression of EGFR elevatedmoderately. More importantly, these alterationswere consistent positively with the expressionof p21, the protein product of H-ras oncogene.CONCLUSION H-ras oncogene could inducethe metastatic phenotype of HCC cell in vitro toraise its metastatic potential. | Qing Wang~1 Zhi Ying Lin~2 Xiao Li Feng~3 ~1Department of Microbiology,Medical Center of Fudan University.the former Shanghai Medical University,Shanghai 200032,China ~2Liver Cancer Institute,Zhongshan Hospital,Shanghai 200032,China ~3Shanghai Institute of Biochemistry,Academy Sinica,Shanghai 200031,ChinaQing Wang earned master degree from Shanghai Medical University in 1996,now a senior lecturer of microbiology,specialized in the role of oncogcncs on tumor metastasis,having 8 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 2 | Draining Tangjiashan Barrier Lake after Wenchuan Earthquake and the flood propagation after the dam break显示文摘Tangjiashan Barrier Lake is one of the largest barrier lakes caused by the Wenchuan Earthquake. Its risk analysis, emergency plan and effect of the emergency plan are introduced in this paper. The dam height of Tangjiashan Barrier Dam is about 105 m, and the reservoir storage capacity is 3.2×108 m3. When the dam broke the flood peak were estimated to be larger than 48000 m3/s, which might cause a enormous disaster to the downstream cities and residents. A discharge channel with 13 m deep and 8 m wide was drug, so that the water may flow out of the lake before the dam breaks. As a result, the drainage and risk mitigation project are successful. During the drainage process, the flood peak was about 6500 m3/s, and about 1.6×108 m3 of water was drained off and the residual reservoir capacity was only 8.97×107 m3. A new channel with average width 100 m was formed, which can bear floods of 200 years frequency. The successful experience and the collected data can be used to deal with the similar natural disasters in future. | LIU Ning1, ZHANG JianXin2, LIN Wei3, CHENG WuYI4 & CHEN ZuYu5 1 Ministry of Water Resources of the People’s Republic of China, Beijing 100053, China 2 Bureau of Hydrology of the Ministry of Water Resources of the People’s Republic of China, Beijing 100053, China 3 Sichuan Hydrographic and Water Resources Survey Bureau Chengdu 610031, China 4 HydroChina Chengdu Engineering Corporation, Chengdu 610072, China 5 China Institute of Water Resources and Hydropower Research, Beijing 100044, China | 2009 | Science China(Technological Sciences)2009，52，4： | 29 |
| 3 | Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle,Fujian Province显示文摘AIM: Genetic polymorphism in enzymes of carcinogen metabolism has been found to have the influence on the susceptibility to cancer. Cytochrome P450 2E1 ( CYP2 E1) is considered to play an important role in the metabolic activation of procarcinogens such as N-nitroscoamines and Iow molecular weight organic compounds. The purpose of this study is to determine whether CYP450 2Elpolymorphisms are associated with risk s of gastric cancer.METHODS: We conducted a population based case-control study in Changle county, Fujian Province, a high-risk region of gastric cancer in China. Ninety-one incident gastric cancer patients and ninety-four healthy controls were included in our study. Datas including dsmographic characteristcs, diet intake, and alcohol and tobacco consumption of indivduals in our study were completed by a standardized questionnaire. PCR-RFLP revealed three genotypes: heterozygote (C1/C2) and two homozygotes (C1/C1 and C2/C2) in CYP2E1.RESULTS: The frequency of variant genotypes (C1/C2 and C2/C2) in gastric cancer cases and controls was 36.3% and 24.5%, respectively. The rare homozygous C2/C2 genotype was found in 6 indivduals in gastric cancer group(6.6%),whereas there was only one in the control group (1.1%).However, there was no statistically significan difference between the two groups (two-tailed Fisher′s exact test, P =0.066). Indivduals in gastric cancer group were more likely to carry genotype C1/C2 (odds ratio, OR = 1.50) and C2/C2(OR = 7.34) than indivduals in control group (X2 = 4.597, for trend P=0.032). The frequencies of genofypes with the C2allele ( C1/C2 and C2/C2 genotypes) were compared with those of genotypes without C2 allele ( C1/C1 genotype )among indivduals in gastric cancer group and control group according to the pattern of gastric cancer risk factors. The results show that indivduals who exposed to these gastric cancer risk factors and carry the C2 allele seemed to have a higher risk of developing gastric cancer.CONCLUSION: Polymorphism of CYP2E1 gene may have some effct in the development of gastric cancer in Changle county, Fujian Province. | Lin Cai~1 Shun-Zhang Yu~2 Zuo-Feng Zhang~3 1 Department of Epidemiology,Fujian Medical University,Fuzhou 350004,Fujian Province,China2 Department of Epidemiology,Shanghai Medical University,Shanghai 200032,China3 Department of Epidemiology,UCLA School of Public Health,Los Angeles California,USA | 2001 | World Journal of Gastroenterology2001，7，6： | 25 |
| 4 | History of the temperature-dependence of susceptibility and its implications: Preliminary results along an E-W transect of the Chinese Loess Plateau显示文摘An investigation of rock magnetic properties using the temperature-dependence ofsusceptibility (TDS) and the coercivity of different IRM components was conducted on samples ofthe Malan loess (L1) and the last interglacial soil (S1) along an E-W transect of the Chinese LoessPlateau. We find that the behavior of the TDS is useful in identifying maghemite (γ-Fe2O3) in bothloess and paleosol, and that it can be used as a new proxy of the degree of pedogenesis, which isclosely linked to climatic conditions. Based on results from the TDS, we conclude that (1) thedetrital magnetite grains predominate in the L1 unit to the west of Liupan Mts, where theweathering and pedogenetic processes were weakest; (2) a comparable degree of pedogenesisexists in the L1 at the east of the Liupan Mts and the S1 at the west of the Liupan Mts; (3) a higherconcentration of maghemite is found in the S1 unit at the eastern sections, suggesting that the localclimate was warmer and more humid in this interval. In addition, we propose that TDSmeasurements can be used as a rapid means of determining the reliability of the paleomagneticsecular variation (PSV) record in loess/poleoso/sequenees. | ZHU Rixiang LIN Mian PAN Yongxin 1) Institute of Geophysics. Chinese Academy of Sciences. Beijing 100101 2) Institute of Mechanism. Chinese Academy of Sciences, Beijing 100080 | 1999 | Chinese Science Bulletin1999，44，S1： | 24 |
| 5 | Efficient production of omega-3 fatty acid desaturase (sFat-1)-transgenic pigs by somatic cell nuclear transfer显示文摘Omega-3(ω-3) fatty acid desaturase transgenic pigs may improve carcass fatty acid composition. The use of transgenic pigs is also an excellent large animal model for studying the role of ω-3 fatty acids in the prevention and treatment of coronary heart disease and cancer. Transgenic pigs carrying synthesized fatty acid desaturase-1 gene (sFat-1) from Caenorhabditis briggsae by somatic cell nuclear transfer (SCNT) were produced for the first time in China. Porcine fetal fibroblast cells were transfected with a sFat-1 expression cassette by the liposome-mediated method. Transgenic embryos were reconstructed by nuclear transfer of positive cells into enucleated in vitro matured oocytes. A total of 1889 reconstructed embryos were transferred into 10 naturally cycling gilts. Nine early pregnancies were established, 7 of which went to term. Twenty-one piglets were born. The cloning efficiency was 1.1% (born piglets/transferred embryos). The integration of the sFat-1 gene was confirmed in 15 live cloned piglets by PCR and Southern blot except for 2 piglets. Expression of the sFat-1 gene in 12 of 13 piglets was detected with RT-PCR. The data demonstrates that an efficient system for sFat-1 transgenic cloned pigs was developed, which led to the successful production of piglets expressing the sFat-1 gene. | PAN DengKe1, ZHANG Li1, ZHOU YanRong2, FENG Chong1, LONG Chuan1, LIU Xiao1, WAN Rong3, ZHANG Jian3, LIN AiXing3, DONG EnQiu4, WANG ShuChen4, XU HouGang4 & CHEN HongXing2 1 Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China 2 Beijing Institute of Biotechnology, Beijing 100071, China 3 China Agricultural University, Beijing 100193, China 4 Yutian Breeding Swine Farms, Yutian 064104, China | 2010 | Science China(Life Sciences)2010，53，4： | 21 |
| 6 | Forecasting the summer rainfall in North China using the year-to-year increment approach显示文摘A new approach to forecasting the year-to-year increment of rainfall in North China in July-August (JA) is proposed. DY is defined as the difference of a variable between the current year and the preceding year (year-to-year increment). NR denotes the seasonal mean precipitation rate over North China in JA. After analyzing the atmospheric circulation anomalies associated with the DY of NR, five key predictors for the DY of NR have been identified. The prediction model for the DY of NR is established by using multi-linear regression method and the NR is obtained (the current forecasted DY of NR added to the preceding observed NR). The prediction model shows a high correlation coefficient (0.8) between the simulated and the observed DY of NR throughout period 1965-1999, with an average relative root mean square error of 19% for the percentage of precipitation rate anomaly over North China. The prediction model makes a hindcast for 2000-2007, with an average relative root mean square error of 21% for the percentage of precipitation rate anomaly over North China. The model reproduces the downward trend of the percentage of precipitation rate anomaly over North China during 1965-2006. Because the current operational prediction models of the summer precipitation have average forecast scores of 60%-70%, it has been more difficult to forecast the summer rainfall over North China. Thus this new approach for predicting the year-to-year increment of the summer precipitation (and hence the summer precipitation itself) has the potential to significantly improve operational forecasting skill for summer precipitation. | FAN Ke1, LIN MeiJing1,2 & GAO YuZhong3 1 Nansen-Zhu International Research Center, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China 2 Graduate University of the Chinese Academy of Sciences, Beijing 100049, China 3 Heilongjiang Meteorological Administration, Harbin 150030, China | 2009 | Science China Earth Sciences2009，52，4： | 18 |
| 7 | Interactions between hotspots and the Southwest Indian Ridge during the last 90 Ma:Implications on the formation of oceanic plateaus and intra-plate seamounts显示文摘This study investigates the relationship between the hotspot-ridge interaction and the formation of oceanic plateaus and seamounts in the Southwest Indian Ocean.We first calculated the relative distance between the Southwest Indian Ridge (SWIR) and relevant hotspots on the basis of models of plate reconstruction,and then calculated the corresponding excess magmatic anomalies of the hotspots on the basis of residual bathymetry and Airy isostasy.The results reveal that the activities of the Marion hotspot can be divided into three main phases:interaction with the paleo-Rodrigues triple junction (73.6-68.5 Ma),interaction with the SWIR (68.5-42.7 Ma),and intra-plate volcanism (42.7-0 Ma).These three phases correspond to the formation of the eastern,central,and western parts of the Del Cano Rise,respectively.The magnitude and apparent periodicity of the magmatic volume flux of the Marion hotspot appear to be dominated by the hotspot-ridge distance.The periodicity of the Marion hotspot is about 25 Ma,which is much longer than that of the Hawaii and Iceland hotspots (about 15 Ma). | ZHANG Tao 1,2,3,4,LIN Jian 5 & GAO JinYao 3,4 1 Institute of Geodesy and Geophysics,Chinese Academy of Sciences,Wuhan 430077,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 The Second Institute of Oceanography,State Oceanic Administrator,Hangzhou 310012,China 4 Key Laboratory of Submarine Geosciences,State Oceanic Administrator,Hangzhou 310012,China 5 Department of Geology and Geophysics,Woods Hole Oceanographic Institution,Woods Hole,MA 02543,USA | 2011 | Science China Earth Sciences2011，54，8： | 16 |
| 8 | Regulation of salt and ABA responses by CIPK14, a calcium sensor interacting protein kinase in Arabidopsis显示文摘Calcium and protein kinase serve as the common mediators to regulate plant responses to multiple stresses including salt and ABA stimulus. Here we reported a novel protein kinase (CIPK14) that regulated the responses to ABA treatment and salt stress in Arabidopsis. CIPK14 transcripts, capable been checked in roots, stems, leaves and flowers, were highly expressed in flowers and roots. CIPK14 was induced by ABA and salt treatments. The disruption of CIPK14 altered the transcriptional pattern of a gene marker line related to ABA and salt responses, and the results suggested that CIPK14 probably was responsible to the control of the salt and ABA responses. Comparing with wild types, the lines inserted with the T-DNA in which CIPK14 gene expression was knocked out were also more sensitive to ABA and salt stimulus, showing low germination rate and the less root elongation. While, when these conditioned seeds were treated with norflurazon, their germination percentages could recover to a certain extent. We also found that exogenous calcium could have an effect on the transcription of CIPK14 under ABA and salt treatments, and it seemed that calcium ion might work upstream CIPK14 to regulate the plant response to ABA and salt response. | QIN YuZhi1,2, LI Xu1, GUO Ming1, DENG KeQin1, LIN JianZhong1, TANG DongYing1, GUO XinHong1 & LIU XuanMing1 1 College of Life Science and Biotechnology, Bioenergy and Biomaterial Research Center, Hunan University, Changsha 410082, China 2 College of living resources & Environment Science, Jishou University, Jishou 416000, China | 2008 | Science China(Life Sciences)2008，51，5： | 16 |
| 9 | Influence of whole peptidoglycan of bifidobacterium on cytotoxic effectors produced by mouse peritoneal macrophages显示文摘INTRODUCTIONBifidobacteria are physiologically beneficial bacteria which are perdominant in human intestine ,and possess the most important functions .They play an important role in maintaining microbial balance of the intestine .Furthermore , their presence is thought to be an important indication of health of the body [1-4].Whole peptidoglycan ( WPG) is the major component in the cell wall of bifidobacterium ,which is also a biological responsemodifier with nontoxic side dffcets. | Li Sheng Wang~1 Hui Ming Zhu~1 Dian Yuan Zhou~2 Yu Lin Wang~1 Wan Dai Zhang~2 ~1Departrnent of Gastroenterology,Shenzhen Municipal People’s Hospital,Jinan University of Medical Sciences,Shenzhen 518020,Guangdong Province,China ~2Chinese PLA Institute of Digestion,the First Military Medical University,Guangzhou 510515,Guangdong Province,ChinaLi Sheng Wang graduated and obtained Ph.D,from the First Military Medical University in 1998,now working at Department of Gastroenterology,Shenzhen Municipal People’s Hospital.Jinan University of Medical Sciences.having 35 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 15 |
| 10 | Rb1 protects endothelial cells from hydrogen peroxide-induced cell senescence by modulating redox status显示文摘Objectives Endothelial senescence has been proposed to be involved in endothelial dysfunction and atherogenesis. This study investigates the effects of ginsenoside Rbl, a major constituent of ginseng,on H2O2-induced endothelial senescence.Methods Primary human umbilical vein endothelial cells(HUVECs) senescence was induced by H2O2 as judged by senescence-associated P-galactosidase assay (SA-P-gal).Fntracellur superoxide dismutase(S0D1) activity and malondialdehyde(MDA) level were determined by commercial kit.S0D1 mRNA and protein expression were analyzed by real time PCR and Western blot.Reactive oxygen species(ROS) were determined by flow cytometry.Results Rb1 was found to reverse endothelial senescence,as witnessed by a significant decrease of senescent cell numbers. Rbl could markedly increase intracellular SOD activity, decrease the MDA level,and suppress the generation of intracellular ROS in H2O2-treated HUVECs.Consistent with these findings,Rbl can effectively restore SOD1 mRNA and protein expression which decreased in H2O2 treated cells. Conclusions Our report demonstrates thatRbl can exert reversal effects on H2O2-induced cellular senescence through modulating cellular redox status. | LIU Ding-hui~1,CHEN Yan-ming~2,LIU Yong~1,HAO Bao-shun~1, ZHOU Bin~1,WU Lin~1,WANG Min~1,CHEN Lin~1,WU Wei-kang~3,QIAN Xiao-xian~1 (1.Department of Cardiology,The Third Affiliated Hospital of Sun Yat-sen University,Guagnzhou 510630 2.Department of Endocrinology,The Third Affiliated Hospital of Sun Yat-sen, Guagnzhou 510630 3.Institute Integrated Traditional Chinese and Western Medicine,Sun Yat-sen University,Guagnzhou 510630) | 2011 | 岭南心血管病杂志2011，17，S1： | 15 |
| 11 | High-resolution climate variability of southwest China during 57―70 ka reflected in a stalagmite δ^(18)O record from Xinya Cave显示文摘A 26-cm-long stalagmite (XY2) from Xinya Cave in northeastern Chongqing of China has been ICP-MS 230Th/U dated, showing a depositional hiatus at 2.3 cm depth from the top. The growth of the 2.3―26 cm interval determined by four dates was between 57 ka and 70 ka, with a linear growth rate of 0.023 mm/a. We have analyzed 190 samples for δ 18O and δ 13C, mostly in the 2.3―26 cm part. The δ 18O and δ 13C values between 57 ka and 70 ka reveal decadal-to-centennial climatic variability during the glacial in-terval of Marine Isotope Stage 4 (MIS4), exhibiting much higher resolution than that of the published Hulu and Dongge records during this interval. Speleothem δ 18O in eastern China, including our study area can be used as a proxy of summer monsoon strength, with lighter values pointing to stronger summer monsoon and higher precipitation, and vice versa. Two decreases in the δ 18O signature of XY2 record around 59.5 and 64.5 Ka are argued to correspond to the Dansgaard-Oeschger (D-O) events 17 and 18 respectively. The Heinrich event 6 (H6) can be identified in the record as a heavy δ 18O peak around 60 ka, indicating significant weakening of the monsoon in Chongqing during the cold period. The XY2 δ 18O record shows very rapid change toward to the interstadial condition of the D-O event, but more gradual change toward to the cold stadial condition. This phenomenon found in the Greenland ice core records is rarely observed so clearly in previously published speleothem records. According to SPECMAP δ 18O record, the glacial maximum of MIS 4 was around 64.5 ka with the boundary of MIS 3/4 around 60 ka. Unlike the marine record, the speleothem record of XY2, China, exhibits much high fre-quency variations without an apparent glacial maximum during MIS 4. However, the timing of MIS 3/4 boundary seems to be around 60 ka when the H6 terminated, in agreement with the marine chronology. The growth period of sample XY2 during glacial times probably reflects a local karstic routing of water, rather than having climatic significance. | LI TingYong1, YUAN DaoXian1,2, LI HongChun1,3 ,YANG Yan2, WANG JianLi1, WANG XinYa1, LI JunYun1, QIN JiaMing2, ZHANG MeiLiang2 & LIN YuShi2 1 College of Geographical Science, Southwest University, Chongqing 400715, China 2 Karst Dynamics Laboratory, Institute of Karst Geology, Chinese Academy of Geological Sciences, Guilin 541004, China 3 Department of Earth Sciences, Cheng-Kung University, Tainan 70101, Taiwan, China | 2007 | Science China Earth Sciences2007，50，8： | 14 |
| 12 | Enrichment mechanisms of rare earth elements in marine hydrogenic ferromanganese crusts显示文摘A series of selective extraction experiments were conducted on marine hydrogenic ferromanganese crusts from the seamount near the Line Island to investigate the distribution of rare earth elements(REEs) and the mechanisms of combination between REEs and the hydrogenic ferromanganese crusts.The enrichment of REEs in hydrogenic ferromanganese crusts is attributed mainly to the mineral or oxide/hydroxide of the crust rather than the growth environment.The REEs are present mainly in amorphous ferric oxide/hydroxide rather than in δ-MnO2.Amorphous ferric oxide/hydroxide preferentially combines free REE3+,while δ-MnO2 combines the REE-carbonate complexes in modern seawater.The REEs in seawater are combined more strongly with amorphous ferric oxide/hydroxides than with δ-MnO2.The positive Ce anomaly in hydrogenic ferromanganese crusts results from the oxidation of soluble Ce3+ to insoluble Ce4+ by the actively soluble oxygen of the bottom current rather than by the oxidation of δ-MnO2. | JIANG XueJun1,2,LIN XueHui1,2,YAO De3,4 & GUO WeiDong5 1 Key Laboratory of Marine Oil and Gas Resources and Marine Environment,Ministry of Land and Resources,Qingdao 266071,China 2 Qingdao Institute of Marine Geology,China Geological Survey,Qingdao 266071,China 3 Institute of Resources and Environment,Shandong University of Technology,Zibo 255049,China 4 Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China 5 Department of Oceanography,Xiamen University,Xiamen 361005,China | 2011 | Science China Earth Sciences2011，54，2： | 14 |
| 13 | Adsorption properties of nitrobenzene in wastewater with silica aerogels显示文摘The adsorption properties of nitrobenzene from wastewater by hydrophobic silica aerogels were investigated.The effects of adsorption intensity by pH value,adsorption temperature,adsorption time and the amount of the silica aerogels were studied.The adsorption principle and mechanism of silica aerogels adsorbing nitrobenzene were discussed along with the Freundlich equation.The results showed that the adsorption intensity of the hydrophobic silica aerogels could reach 68.76% at better adsorption conditions of adsorption temperature 25°C,pH value 8.35,the amount of SiO2 aerogels dosage 3.33 g/L,and adsorption time of 30 min,and that the adsorption properties were related to the hydrophobility of aerogels,surface area of organic solution,structure of aerogels. | CUI Sheng1,LIU XueYong2,LIU Yu2,SHEN XiaoDong1,LIN BenLan1,3,HAN GuiFang1 & WU ZhanWu1 1 College of Material Science and Engineering,Nanjing University of Technology,Nanjing 210009,China 2 Institute of Chemical Materials,CAEP,Mianyang 621900,China 3 Editorial Board of Journal,Nanjing University of Technology,Nanjing 210009,China | 2010 | Science China(Technological Sciences)2010，53，9： | 13 |
| 14 | Research on Methods of Ecological Security Assessment of the Middle and Lower Reaches of Liaohe River Based on GIS显示文摘Ecological security assessment and early warning research possess the attributes of spatiality, non-linearity and randomicity, so we must process much spatial information. Spatial analysis and data management are the advantages of GIS, which can define distribution trend and spatial relations of environmental factors, and show ecological security pattern graphically. Spatial differences of ecological security assessment based on GIS are discussed in this paper, of which the middle and lower reaches of the Liaohe River is taken as a study case. First, to work out pressure-state-response (P-S-R) assessment indicators system, and investigate in person and gather information; second, to digitize the watershed; third, to quantize and calculate by the fuzzy method; last, to construct GIS grid database, and expound spatial differences of ecological security by GIS interpolation and assembly analysis. | Wang Geng 1,2 , Nie Baochi 3, Wang Lin 1 & Wu Wei 1 1. School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China 2. Urban and Environmental School, Liaoning Normal University, Dalian 116029, China 3. Shenyang Buraue of Water Resources, Shenyang 110013, China. | 2005 | Chinese Journal of Population,Resources and Environment2005，3，4： | 12 |
| 15 | Reverse reconciliation for continuous variable quantum key distribution显示文摘An efficient and practical post-processing technique based on reverse reconciliation for continuous variable quantum key distribution is proposed and simulated with low-density parity check (LDPC) codes. MultiLevel Coding/ MultiStage Decoding, which fully utilizes optimization technique such as vector quantization and iterative decoding and the optimal channel coding most close to the Shannon limit, was used to realize efficient reverse reconciliation algorithm. Simulation results showed that the proposed method can improve the secure key distribution rate to 2.2 kb/s and the coding efficiency to 0.89 over 20 km in single-mode optical fiber. Moreover, there still is room for much improvement. | LU ZhiXin 1,2 , YU Li 1,2 , LI Kang 1,2 , LIU BingCan 1,2,3 , LIN JianGui 1,2 , JIAO RongZhen 1,2 & YANG BoJun 1,21 School of Science, Beijing University of Posts and Telecommunications, Beijing 100876, China 2 Key Laboratory of Information Photonics and Optical Communication, Ministry of Education, Beijing University of Posts and Telecommunications, Beijing 100876, China 3 Department of Fundamental Courses, Academy of Armored Force Engineering, Beijing 100072, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 12 |
| 16 | Eigenvalue approximation from below using non-conforming finite elements显示文摘This is a survey article about using non-conforming finite elements in solving eigenvalue problems of elliptic operators,with emphasis on obtaining lower bounds. In addition,this article also contains some new materials for eigenvalue approximations of the Laplace operator,which include:1) the proof of the fact that the non-conforming Crouzeix-Raviart element approximates eigenvalues associated with smooth eigenfunctions from below;2) the proof of the fact that the non-conforming EQ rot1 element approximates eigenvalues from below on polygonal domains that can be decomposed into rectangular elements;3) the explanation of the phenomena that numerical eigenvalues λ 1,h and λ 3,h of the non-conforming Q rot1 element approximate the true eigenvalues from below for the L-shaped domain. Finally,we list several unsolved problems. | YANG YiDu 1 ,ZHANG ZhiMin 2 & LIN FuBiao 11 School of Mathematics and Computer Science,Guizhou Normal University,Guiyang 550001,China 2 Department of Mathematics,Wayne State University,Detroit,MI 48202,USA | 2010 | Science China Mathematics2010，53，1： | 12 |
| 17 | Diet and gastric cancer:a case-control study in Fujian Province,China显示文摘NTRODUCTIONChangleandFuqingcitiesarelocatedinthesoutheasternpartofFujianProvince,Chinawithahighincidenceofgastriccancer.Howev... | YE Wei Min 1, YI Ying Nan 1, LUO Ren Xia 2, ZHOU Tian Shu 3, LIN Ru Tao 1 and CHEN Gui Dong 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 12 |
| 18 | Transient expression and antigenic characterization of HBsAg of HBV nt551 A to G mutant显示文摘NTRODUCTIONFromthelate80s,therehavebeenincreasingnumberofreportsonhepatitisB(HB)patientswithatypicalHBVserologicalmarkers,so... | FANG De Xing 1, LI Fa Qing 1, TAN Wei Guo 1, CHEN Hua Biao 1, JIN Hui Ying 1, LI Su Qin 1, LIN Hou Ji 2 and ZHOU Zhen Xian 2 | 1999 | World Journal of Gastroenterology1999，5，1： | 10 |
| 19 | Influence of L-methionine-deprived total parenteral nutrition with 5-fluorouracil on gastric cancer and host metabolism显示文摘AIM To investigate the influence of L-methioninedeprived total parentaral nutrition with 5-FU on gastric cancer and host metabolism.``METHODS N-methyI-N-nitro-nitrosoguanidine ( MNNG )induced gastric cancer rats were randomly divided into four groups: Met-containing TPN group (n= 11 ), Metdeprived TPN group (n = 12), Met-containing TPN + 5-FU group (n = 11) and Met-deprived TPN + 5-FU group (n-12). Five rats in each group were sacrificed after 7days of treatment and the samples were taken for examination. The remaining rats in each group were then fed separately with normal diet after the treatment until death, the life span was noted.``RESULTS The tumors were enlarged in Met-containing group and shrank in Met-deprived group markedly after the treatment. The DNA index (DI) of tumor cells and the body weight (BW) of rats had no significant change in the two groups, however, the ratio of tumor cells' S phase was increased The ratio of G2M phase went up in Metcontaining group, but down in Met-deprived group. In the other two groups that 5-FU was added, the BW of rats,and the diameter of tumors, the DI of tumor cells, the S and G2M phase ratio of tumor cells were all decreased,particularly in Met-deprived plus 5-FU group. Pathological examination revealed that the necrotic foci of the tumor tissue increased after Met-deprived TPN treatment, and the nucleoli of tumor cells enlarged. In -MetTPN + 5-FUgroup, severe nuclear damage was also found by karyopyknosis and karyorrhexis, meanwhile there was slight degeneration in some liver and kidney cells. The serum free Met and Cysteine decreased markedly (P<0.001), while other amino acids, such as serum free serine and glutamine increased significantly ( P< 0.005).All the rats died of multiple organ failure caused by cancer metastasis. The average survival time was 18.6 days in Met-containing TPN group. 31 days in Met-deprived TPN group, 27.5 days in Met-containing TPN + 5-FU group, and 43 days in Met-deprived TPN+ 5-FU group (P<0.05).``CONCLUSION Met-deprived TPN causes methionine starvation of tumor cells, and can enhance the anti-tumor effect of 5-FU and prolong the life span of gastric cancerbearing rats. | Hong-Bing Xiao~1 Wei-Xin Cao~2 Hao-Ran Yin~2 Yan-Zhen Lin~2 Shi-Hui Ye~1 1 Department of Surgery,Affiliated Railway Hospital,Tongji University,Shanghai 200072,China2 Department of Surgery,Affiliated Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China | 2001 | World Journal of Gastroenterology2001，7，5： | 9 |
| 20 | Development and application of ergodicity model with FRCM and FLAR for hydrological process显示文摘In this paper, a new ergodic property analysis model of hydrological process is proposed based on fuzzy-rough c-means clustering (FRCM), autocorrelogram, and fuzzy least absolute regression (FLAR). A precipitation time series (1951―2004) from Shanghai Hydrology Station is then analyzed with the model. The results show that the precipitation time series of April, May, June, and September has er-godic property. We conclude that in the long run, the precipitation of April, May, June, and September will not keep decreasing; it will converge to its mean value in some period. | WANG HongRui1, FENG QiLei2, LIN Xin3 & ZENG WenYi4 1 College of Water Science, Key Laboratory for Water and Sediment Sciences of the Ministry of Education, Beijing Normal University, Beijing 100875, China 2 School of Science, Beijing Institute of Education, Beijing 100011, China 3 School of Mathematical Sciences, Beijing Normal University, Beijing 100875, China 4 College of Information Science and Technology, Beijing Normal University, Beijing 100875, China | 2009 | Science China(Technological Sciences)2009，52，2： | 9 |
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