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106篇 您的检索式：作者名="Limache"

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	题名	作者	年代	出处	被引量
1	Stem cell treatment and cerebral palsy: Systemic review and meta-analysis显示文摘BACKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(CP)is the most severe motor disability.Once developed,CP is a nonprogressive disease with a prevalence of 1-2 per 1000 live births in developed countries.It demands an extensive and multidisciplinary care.Therefore,it is a challenge for our health system and a burden for patients and their families.Recently,stem cell therapy emerged as a promising treatment option and raised hope in patients and their families.AIM The aim is to evaluate the efficacy and safety of stem cell treatment in children with CP using a systematic review and meta-analysis METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials(RCT)investigating the effect of stem cell transplantation in children with CP.After the review,we performed a randomeffects meta-analysis focusing on the change in gross motor function,which was quantified using the gross motor function measure.We calculated the pooled standardized mean differences of the 6-and/or 12-mo-outcome by the method of Cohen.We quantified the heterogeneity using the I-squared measure.RESULTS We identified a total of 8 RCT for a qualitative review.From the initially selected trials,5 met the criteria and were included in the meta-analysis.Patients’population ranged from 0.5 up to 35 years(n=282).We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95(95%confidence interval:0.13-1.76)favoring the stem cell group and a high heterogeneity(I2=90.1%).Serious adverse events were rare and equally distributed among both intervention and control groups.CONCLUSION Stem cell therapy for CP compared with symptomatic standard care only,shows a significant positive effect on the gross motor function,although the magnitude of the improvement is limited.Short-term safety is present and further highquality RCTs are needed.	Simone Eggenberger Céline Boucard Andreina Schoeberlein Raphael Guzman Andreas Limacher Daniel Surbek Martin Mueller	2019	World Journal of Stem Cells2019，11，10：	8
2	Effects of conjugated e- quine estrogen in postmenopansal women with hysterectomy: the Women's Health Initiative randomized controlled trial 显示文摘	Anderson GL Limacher M Assaf AR	2004	JAMA2004，291，14：	1
3	Effects of conjugated equine estrogen in postmenopausal women with hysterectomy:the Women's Health Initiative randomized controlled trial显示文摘	Anderson GL Limacher M Assaf AR	2004	JAMA2004，291，14：	1
4	Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial 显示文摘	Anderson GL Limacher M Assaf AR Women' s Health Initiative Steering Committee	2004	JAMA2004，291，14：	1
5	Effects of conjugated equine estrogen in postmenopausal women with hysterectomy:the Women's Health Initiative randomized controlled trial 显示文摘	Anderson GL Limacher M Assaf AR	2004	JAMA2004，291，14：	1
6	Effects of conjuga- ted equine estrogen in postmenopausal women with hysterectomy: The Womens Health Initiative randomized controlled tria I 显示文摘	Anderson GL Limacher M Assaf AR	2004	JAMA2004，291，：	1
7	Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial 显示文摘	Anderson GL Limacher M Assaf AR	2004	JAMA2004，291，：	1
8	Effects of conjugated equine estrogen in post menopausal women with hysterectomy:the women's health initiative randomized controlled trail显示文摘	Anderson G L Limacher M Assaf A R	2004	JAMA2004，291，14：	1
9	Effects of conjugated equine estrogen in postmenopausal women with hysterectomy:The Women's Health Initiative randomized controlled trial显示文摘	Anderson GL Limacher M Assaf AR	2004	JAMA2004，291，14：	1
10	Enhancing the reliability and throughput of neurosphere culture on hydrogel microwell arrays显示文摘	Cordey M Limacher M Kebel S	2008	Stem Cells2008，26，10：	1
11	Effects of conjuga- ted equine estrogen in postmenopausal women with hysterectomy: the Womeffs Health Initiative randomized controlled trial显示文摘	Anderson GL Limacher M Assaf AR	2004	JA- MA2004，291，14：	1
12	Formation of furan and methylfuran by maillard-type reactions in model systems and food显示文摘	Limacher A Kerler J Davidek T	2008	Journal of Agricultural and Food Chemistry2008，56，10：	1
13	Effects of conjugated equine estrogen in postmenopausal women with hysterectomy:the Women's Health Initiative randomized controlled trial显示文摘	Anderson GL Limacher M Assaf AR		0，，14：	1
14	Effects of conjugated e- quine estrogen in postmenopausal women with hysterectomy: The Women's Health Initiative randomized controlled trial 显示文摘	Anderson GL Limacher M Assaf AR	2004	JAMA2004，291，14：	1
15	Influence of thermal processing conditions on aerylamide genera- tion and browning in a potato model system显示文摘	Amrein T M Limacher C P Amado R	2006	Journal of Agricultural and Food Chemistry2006，54，16：	1
16	Effect of estrogen plus progestin on stroke inpostmenopausal women:the Women's Health Initiative:a randomized trial显示文摘	Wassertheil-Smoller S Hendrix SL Limacher M	2003	JAMA2003，289，：	1
17	Detection of 11 germline inactivating TP53 mutations and absence of TP63 and HCHK2 mutations in 17 French families with Li-Fraumeni or Li- Fraumeni-like syndrome 显示文摘	Bougeard G Limacher JM Martin C	2001	J Med Genet2001，38，4：	1
18	MUC1 as a target antigen for cancer immunotherapy显示文摘	Acres B Limacher JM	2005	Expert Rev Vaccines2005，4，4：	1
19	TG4010:A therapeutic vaccine against MUC1 expressing tumors显示文摘	Limacher JM Quoix E		0，，05：	1
20	Discovery and development of therapeutic cancer vaccines显示文摘	Acres B Limacher JM Bonnefoy J	2007	Curr Opin Drug Discov Devel2007，10，2：	1

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