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270篇 您的检索式：作者名="Lilly D"

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	题名	作者	年代	出处	被引量
1	Oxidative stress in alcohol-related liver disease显示文摘Alcohol consumption is one of the leading causes of the global burden of disease and results in high healthcare and economic costs.Heavy alcohol misuse leads to alcohol-related liver disease,which is responsible for a significant proportion of alcohol-attributable deaths globally.Other than reducing alcohol consumption,there are currently no effective treatments for alcohol-related liver disease.Oxidative stress refers to an imbalance in the production and elimination of reactive oxygen species and antioxidants.It plays important roles in several aspects of alcohol-related liver disease pathogenesis.Here,we review how chronic alcohol use results in oxidative stress through increased metabolism via the cytochrome P4502E1 system producing reactive oxygen species,acetaldehyde and protein and DNA adducts.These trigger inflammatory signaling pathways within the liver leading to expression of pro-inflammatory mediators causing hepatocyte apoptosis and necrosis.Reactive oxygen species exposure also results in mitochondrial stress within hepatocytes causing structural and functional dysregulation of mitochondria and upregulating apoptotic signaling.There is also evidence that oxidative stress as well as the direct effect of alcohol influences epigenetic regulation.Increased global histone methylation and acetylation and specific histone acetylation inhibits antioxidant responses and promotes expression of key pro-inflammatory genes.This review highlights aspects of the role of oxidative stress in disease pathogenesis that warrant further study including mitochondrial stress and epigenetic regulation.Improved understanding of these processes may identify novel targets for therapy.	Huey K Tan Euan Yates Kristen Lilly Ashwin D Dhanda	2020	World Journal of Hepatology2020，12，7：	6
2	A proposed modification of the Germano subgrid scale closure method显示文摘	Lilly D	1992	Physics of Fluids1992，4，3：	1
3	A proposed modification of the germano subgrid scale closure method显示文摘	Lilly D		0，，03：	1
4	Probiotics:growth-promoting factors produced by microorganisms显示文摘	Lilly D M Stillwell R H	1965	Science1965，147，5：	1
5	Experimental study on mass transfer from pyrolysing coal particles显示文摘	Suuberg E M Unge P E Lilly W D	1985	Fuel1985，64，：	1
6	A comparison of hydraulic conductivities, permeabilities and infiltration rates in frozen and unfrozen soils 显示文摘	MCCLAULEY C A WHITE D M LILLY M R	2002	Cold Reg Sci Technol2002，34，：	1
7	Probiotics:growth-promoting factors produced by microorganisms显示文摘	LILLY D M STILLWELL R H	1965	Science1965，147，：	1
8	Bacterial li- popolysaccharide induces an endocrine switch from prostaglandin F2alpha to prostaglandin E2 in bovine endometrium 显示文摘	Herath S Lilly S T Fischer D P	2009	Endocrinol2009，150，4：	1
9	Isolation and kinetics of penicillin amidase from Escherichia call显示文摘	Balasing K Warburto D Dunnill P Lilly M D	1972	Biochimica Et Biophysica Acta1972，276，1：	1
10	Recovery of three-dimensional wind and temperature fields from simulated single-doppler radar data显示文摘	Flicker D W Lilly D K	1991	J Atmos Sci1991，48，6：	1
11	Probiotics : growth- promoting factors produced by microorganisms 显示文摘	Lilly D M Stillwe11 R H	1965	Science1965，147，：	1
12	A proposed modification of the Germano Subgrid-scale closure method显示文摘	Lilly D K	1991	Physics of Fluids1991，4，3：	1
13	The effect of agitation on the morphology and production of Penicillium chrysogenum 显示文摘	Smith J J Lilly M D Fox R I	1990	Biotechnol Bioeng1990，35，10：	1
14	A proposed modification of the Germanosubgrid-scale closure method显示文摘	Lilly D	1992	Physics of Fluids A1992，4，3：	1
15	Probiotics: gTowih-promoting factors produced by microorganisms 显示文摘	Lilly D M Stillwell R H	1965	Science1965，147，：	1
16	Model of cloud-topped mixed layers under a strong inversion显示文摘	Lilly D K	1968	Journal of the Royal Meteorological Society1968，94，401：	1
17	A Proposed Modification of the Germano Subgrid - scale Closure Method 显示文摘	D K Lilly	1992	Physics of Fluids A1992，，4：	1
18	A proposed modification of the germano subfrid-scale closure method 显示文摘	Lilly D K	1993	Phys Fluids1993，，4：	1
19	The utility of PBPK in the safety assessment of chloroform and carbon tetrachloride显示文摘	DELIC J I LILLY P D MACdONALD A J	2000	Regulatory Toxicology and Pharmacology2000，32，2：	1
20	Carbon stocks in Scottish peatlands 显示文摘	Chapman S Bell J Donnelly J D Lilly A	2009	Soil Use and Management2009，25，：	1

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