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159篇 您的检索式:作者名="Lilli K"
    题名 作者 年代 出处 被引量
1Oxidative stress in alcohol-related liver disease显示文摘Alcohol consumption is one of the leading causes of the global burden of disease and results in high healthcare and economic costs.Heavy alcohol misuse leads to alcohol-related liver disease,which is responsible for a significant proportion of alcohol-attributable deaths globally.Other than reducing alcohol consumption,there are currently no effective treatments for alcohol-related liver disease.Oxidative stress refers to an imbalance in the production and elimination of reactive oxygen species and antioxidants.It plays important roles in several aspects of alcohol-related liver disease pathogenesis.Here,we review how chronic alcohol use results in oxidative stress through increased metabolism via the cytochrome P4502E1 system producing reactive oxygen species,acetaldehyde and protein and DNA adducts.These trigger inflammatory signaling pathways within the liver leading to expression of pro-inflammatory mediators causing hepatocyte apoptosis and necrosis.Reactive oxygen species exposure also results in mitochondrial stress within hepatocytes causing structural and functional dysregulation of mitochondria and upregulating apoptotic signaling.There is also evidence that oxidative stress as well as the direct effect of alcohol influences epigenetic regulation.Increased global histone methylation and acetylation and specific histone acetylation inhibits antioxidant responses and promotes expression of key pro-inflammatory genes.This review highlights aspects of the role of oxidative stress in disease pathogenesis that warrant further study including mitochondrial stress and epigenetic regulation.Improved understanding of these processes may identify novel targets for therapy.Huey K Tan Euan Yates Kristen Lilly Ashwin D Dhanda 2020World Journal of Hepatology2020,12,7:6
2Piloting case -based instruc- tion in a didactic clinical immunology course 显示文摘HOAG K LILLIE J HOPPER 2005Journal of the American Society for Medical Technology2005,18,4:1
3Heminested multiplex RT- PCR for detection and differentiation of Norwalk-like virus genogroups land 2 in fecal samples显示文摘Lilly K W Y Michael G C 2001J Clin Microbiol2001,39,:1
4A Proposed Modification of the Germano Subgrid-Scale Closure Model显示文摘Lilly K 1992Physics of Fluids1992,4,:1
5Prostaglandin G/H synthase-2 is the constitutive and dominant isoform in cultured human lung epithelial cells显示文摘Asano K Lilly CM Drazen JM 1996Am J Physiol1996,271,11:1
6Isolation and kinetics of penicillin amidase from Escherichia call显示文摘Balasing K Warburto D Dunnill P Lilly M D 1972Biochimica Et Biophysica Acta1972,276,1:1
7lnitiation of activation of a preemergent herbicide by a novel alkylsulfatase of Pseudomonas putida FLA 显示文摘Lillis V Dodgson K S White G F 1983Applied & Environmental Microbiology1983,46,5:1
8Recovery of three-dimensional wind and temperature fields from simulated single-doppler radar data显示文摘 Flicker D W Lilly D K 1991J Atmos Sci1991,48,6:1
9Sequestration of acetylated LDL and cholesterol crystals by human monocytederived macrophages显示文摘Kruth HS Skarlatos SI Lilly K 1995Cell Biol1995,129,1:1
10A proposed modification of the Germano Subgrid-scale closure method显示文摘Lilly D K 1991Physics of Fluids1991,4,3:1
11A genetic model defines the importance of the atrial natriuretic peptide receptor (guanylyl cyclase-A) in the regulation of kidney function 显示文摘DUBOIS S K KISHIMOTO I LILLIS T O 2000PNAS2000,97,8:1
12Hindbrain orexin 1 receptorsinfluence palatable food intake, operant responding for food, andfood-conditioned place preference in rats 显示文摘Kay K Parise E M Lilly N 2014Psychopharmacology2014,231,2:1
13Dynamic simulation and neural network compliance control of an intelligent forging center显示文摘LILLY K W MELLIGERI A S 1996Journal of Intelligent & Robotic Systems1996,17,1:1
14Prostaglandin G/H synthase-2 is the constitutive and dominant isoform in cultured lung epithelial cells显示文摘Asano K Lilly CM Drazen DM 1996Am J Physiol1996,271,:1
15Model of cloud-topped mixed layers under a strong inversion显示文摘Lilly D K 1968Journal of the Royal Meteorological Society1968,94,401:1
16Bryostatin 1 acts synergistically with interleukin-1 alpha to induce secretion of GCSF and other cytokines from marrow stromal cells显示文摘 Vo K le T 1996Exp Hematol1996,24,5:1
17A Proposed Modification of the Germano Subgrid - scale Closure Method 显示文摘D K Lilly 1992Physics of Fluids A1992,,4:1
18A proposed modification of the germano subfrid-scale closure method 显示文摘Lilly D K 1993Phys Fluids1993,,4:1
19Dynamic Simulation and Neural Network Compliance Control of an Intelligent Forging Center 显示文摘Lilly K W Melligeri A S 1996Journal of Intelligent and Robotic Systems (S0921-0296)1996,17,1:1
20Diurnal variation of urinary leukotriene E4 and histamine excretion rates in normal subjects and patients with mild-to- moderate asthma 显示文摘Asano K Lilly CM O'Donnell WJ Israel E Fischer A Ransil B J 1995J Allergy Clin Immunol1995,96,51:1
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