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| 1 | Effect of arsenic trioxide on human hepatocarcinoma in nude mice显示文摘AIM: To study the effect of arsenic trioxide (As2O3) on human hepatoma cell line BEL-7402 in vivo.METHODS: Human hepatoma cell line BEL-7402 cultured in vitro was inoculated into nude mice and arsenic trioxide,5-Fu and saline were injected into abdominal cavity of the nude mice respectively. The volumes of tumor and general conditions of the nude mice and structural changes of the liver and kidney were observed. Morphologic changes were studied under electron microscope. Expression of AFP was investigated by immunohistochemical method.RESULTS: As2O3 could inhibit the growth of tumor. The tumor growth inhibitory rate in mice treated with 2.5 mg/kg As2O3 was 53.42% on the tenth day. The tumor growth inhibitory rate in mice treated with 5 mg/kg As2O3 was 79.28% on the fifth day and 96.58% on the tenth day respectively. As2O3 did not damage the liver and kidney of nude mice, or affect the blood system. Typical apoptotic morphological changes were found under electron microscope, and the change of mitochondria was obvious. The expression rate of AFP declined after treatment.CONCLUSION: Arsenic trioxide can induce apoptosis of human hepatoma cells, and inhibit proliferation of tumor with no obvious side effects on liver and kidney. | Hong-YuXu You-LinYang Shu-MeiLiu LiBi Shu-XiangChen | 2004 | World Journal of Gastroenterology2004，10，24： | 24 |
| 2 | 癌症化学预防:过去,现在和未来(英文)显示文摘本文将对癌症化学预防的发展历史、研究现状及其未来前景作一简要评述,主要包括以下内容:癌症化学预防的科学基础,正在使用的癌症化学预防药物,对新合成药物的需求,以及面临的挑战等。本文尤其强调了联合用药在有效的癌症预防中的重要性。 | Michael B. Sporn Karen T. Liby | 2013 | 化学进展2013，25，9： | 2 |
| 3 | Polysaccharideoligoamine based conjugates for gene delivery 显示文摘 | TONY AZZAM HAGIT ELIYAHU LIBI SHAPIRA | 2002 | J Med Chem2002，45，9： | 1 |
| 4 | Strengthening steel bridge sections using CFRP laminates显示文摘 | Sen R Liby L Mullins G | 2001 | Composites Part B-Engineering2001，32，4： | 1 |
| 5 | Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer 显示文摘 | Liby KT Yore MM Spore MB | 2007 | Nat Rev Cancer2007，7，5： | 1 |
| 6 | New synthetic triterpe- noids: Potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress 显示文摘 | SPORN M B LIBY K T YORE M M | 2011 | J Nat Prod2011，74，3： | 1 |
| 7 | Human neuroblasto- ma cells rapidly enter cell cycle arrest and apoptosis following ex- posure to C-28 derivatives of the synthetic triterpenoid CDDO显示文摘 | ALABRAN J L CHEUK A LIBY K | 2008 | Cancer Biol Ther2008，7，5： | 1 |
| 8 | The synthetic triter- penoid 1 - imid- azole blocks nuclear factor-kappaB activation through direct inhi- bition of IkappaB kinase beta 显示文摘 | YORE M M LIBY K T HONDA T | 2006 | Mol Cancer Ther2006，5，12： | 1 |
| 9 | New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflamma- tory and oxidative stress 显示文摘 | SPORN M B LIBY K T YORE M M | 2011 | J Nat Prod2011，74，3： | 1 |
| 10 | Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide显示文摘 | Thimmulappa RK Scollick C Traore K Yates M Trush MA Liby KT | 2006 | Biochem Biophys Res Commun2006，351，4： | 1 |
| 11 | JunB and JunD regulate hu- man heme oxygenase-1 gene expression in renal epithelial cells 显示文摘 | Hock TD Liby K Wright MM | 2007 | J Biol Chem2007，9，68： | 1 |
| 12 | Triterpenoids and rexinoids as multifunctional agents for the pre- vention and treatment of cancer 显示文摘 | LIBY K T YORE M M SPORN M B | 2007 | Nat Rev Can- cer2007，7，5： | 1 |
| 13 | Synthetic oleanane triterpe- noids:multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease 显示文摘 | LIBY K T SPORN M B | 2012 | Pharmacol Rev2012，64，4： | 1 |
| 14 | A novel acetylenic tricyclic bis-( cyano enone) potently induces phase 2 cytoprotec- tire pathways and blocks liver carcinogenesis induced by aflatoxin 显示文摘 | LIBY K YORE M M ROEBUCK B D | 2008 | Cancer Res2008，68，16： | 1 |
| 15 | Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo - controlled study 显示文摘 | Jamerot G Hertervig E Friis -Liby I | 2005 | Gastroenterology2005，128，： | 1 |
| 16 | Clinical trial: colectomy after rescue therapy in ulcerative colitis – 3‐year follow‐up of the Swedish‐Danish controlled infliximab study显示文摘 | A.Gustavsson G.J?rnerot E.Hertervig I.Friis‐Liby L.Blomquist P.Karlén C.Gr?nn? M.Vilien M.Str?m H.Verbaan P. M.Hellstr?m A.Magnuson J.Halfvarson C.Tysk | 2010 | Alimentary Pharmacology & Therapeutics2010，，8： | 1 |
| 17 | Infliximab as rescue therapy in severe to moderately severe ulcerative colitis : a randomized, placebo - controlled study 显示文摘 | Jarnerot G Hertervig E Friis - Liby I | 2005 | Gastroenterology2005，128，7： | 1 |
| 18 | Strengthening Steel Bridge Sections Using CFRP Laminates 显示文摘 | Rajon Sen Larry Liby Gray Mullins | 2001 | Composites: Part B2001，32，： | 1 |
| 19 | NRF2 and cancer: the good, the bad and the importance of context显示文摘 | Spore M B Liby K T | 2012 | Nat Rev Cancer2012，12，8： | 1 |
| 20 | NRF2 and cancer: the good, the bad and the importance of context显示文摘 | Sporn MB Liby KT | 2012 | Nature Reviews Cancer2012，12，8： | 1 |
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