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| 1 | Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?显示文摘AIM To investigate the correlation of iodine concentration(IC) generated by spectral computed tomography(CT) with micro-vessel density(MVD) and vascular endothelial growth factor(VEGF) expression in patients with advanced gastric carcinoma(GC).METHODS Thirty-four advanced GC patients underwent abdominal enhanced CT in the gemstone spectral imaging mode. The IC of the primary lesion in the arterial phase(AP) and venous phase(VP) were measured, and were then normalized against that in the aorta to provide the normalized IC(nI C). MVD and VEGF were detected by immunohistochemical assays, using CD34 and VEGF-A antibodies, respectively. Correlations of nI C with MVD, VEGF, and clinical-pathological features were analyzed.RESULTS Both nI Cs correlated linearly with MVD and were higher in the primary lesion site than in the normal control site, but were not correlated with VEGF expression. After stratification by clinical-pathological subtypes, nI C-AP showed a statistically significant correlation with MVD, particularly in the group with tumors at stage T4, without nodular involvement, of a mixed Lauren type, where the tumor was located at the antrum site, and occurred in female individuals. nI C-VP showed a positive correlation with MVD in the group with the tumor at stage T4 and above, had nodular involvement, was poorly differentiated, was located at the pylorus site, of a mixed and diffused Lauren subtype, and occurred in male individuals. nI C-AP and nI C-VP showed significant differences in terms of histological differentiation and Lauren subtype.CONCLUSION The IC detected by spectral CT correlated with the MVD. n IC-AP and n IC-VP can reflect angiogenesis in different pathological subgroups of advanced GC. | Xiao-Hua Chen Ke Ren Pan Liang Yaru Chai Kui-Sheng Chen Jian-Bo Gao | 2017 | World Journal of Gastroenterology2017，23，9： | 47 |
| 2 | Characteristics of and strategies for patients with severe burn-blast combined injury显示文摘背景严重灼伤强风联合了损害是对为它的高死亡的医疗队的大挑战。这研究的目的是阐明损害并且到现在的临床的特征我们有严重灼伤强风的五个病人联合了的如此的 cases.Methods 的治疗上的临床的经验损害进入我们在 2005 年 6 月 7 日 77 个小时损害以后的医院。灼伤程度从 80% ~ 97%(89.6% 鞪? 亘吗?? | CHAI Jia-ke SHENG Zhi-yong LU Jiang-yang WEN Zhong-guang YANG Hong-ming JIA Xiao-ming LI Li-gen CAO Wei-hong HAO Dai-feng SHEN Chuan-an TUO Xiao-ye LIANG Li-ming WANG Shu-jun | 2007 | Chinese Medical Journal2007，，20： | 17 |
| 3 | Metabolic engineering and flux analysis of Corynebacterium glutamicum for L-serine production显示文摘L-Serine plays a critical role as a building block for cell growth, and thus it is difficult to achieve the direct fermentation of L-serine from glucose. In this study, Corynebacterium glutamicum ATCC 13032 was engineered de novo by blocking and attenuating the conversion of L-serine to pyruvate and glycine, releasing the feedback inhibition by L-serine to 3-phosphoglycerate dehydrogenase (PGDH), in combination with the co-expression of 3-phosphoglycerate kinase (PGK) and feedback-resistant PGDH (PGDHr). The resulting strain, SER-8, exhibited a lower specific growth rate and significant differences in L-serine levels from Phase I to Phase V as determined for fed-batch fermentation. The intracellular L-serine pool reached (14.22±1.41) μmol gCDM 1, which was higher than glycine pool, contrary to fermentation with the wild-type strain. Furthermore, metabolic flux analysis demonstrated that the over-expression of PGK directed the flux of the pentose phosphate pathway (PPP) towards the glycolysis pathway (EMP), and the expression of PGDHr improved the L-serine biosynthesis pathway. In addition, the flux from L-serine to glycine dropped by 24%, indicating that the deletion of the activator GlyR resulted in down-regulation of serine hydroxymethyltransferase (SHMT) expression. Taken together, our findings imply that L-serine pool management is fundamental for sustaining the viability of C. glutamicum, and improvement of C1 units generation by introducing the glycine cleavage system (GCV) to degrade the excessive glycine is a promising target for L-serine production in C. glutamicum. | LAI ShuJuan ZHANG Yun LIU ShuWen LIANG Yong SHANG XiuLing CHAI Xin WEN TingYi | 2012 | Science China(Life Sciences)2012，55，4： | 15 |
| 4 | Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases显示文摘 | Xiangxiu Liang Miaomiao Ma ,Zhaoyang Zhou Jinlong Wang Xinru Yang Shaofei Rao Guozhi Bi Lin Li Xiaojuan Zhang Jijie Chai She Chen Jian-Min Zhou | 2018 | Cell Research2018，28，5： | 13 |
| 5 | Elevated IL-37 levels in the plasma of patients with severe coronary arterycalcification显示文摘Background Coronary artery calcification (CAC) is a predictor of cardiovascular events and plaque burden and is closely associatedwith chronic inflammation. Intedeukin (IL)-37 is a newly discovered member of the IL-1 family and is considered an anti-inflammatorycytokine. Our recent study on mice indicated that IL-37 could attenuate atherosclerosis and vascular calcification, which suggests that IL-37could be associated with the development of atherosclerosis and related diseases. The aim of this study was to investigate if IL-37 plays arole in the progression of CAC in patients. Methods Two hundred participants with suspected cardiovascular disease were recruited. Thelevels of plasma IL-37, osteoprotegerin (OPG), hypersensitive C-reactive protein (hsCRP) together with other biochemical parameters weremeasured, and a coronary calcium assessment was carried out by multi-detector row CT. A score of 〈 10 AU (Agatston units) denotes anabsence of CAC, a score of 11-100 AU denotes mild CAC, 101-400 denotes moderate CAC, and 〉 400 AU denotes severe CAC. ResultsOur initial data showed that there were no apparent differences in plasma IL-37 levels among patients with or without mild or moderate CAC.However, IL-37 levels were significantly increased in patients with severe CAC (P 〈 0.001). Similar results were observed for plasma OPGand hsCRP levels. When IL-37 levels in patients with severe calcification were compared with that in all of the other non-severe CAC groups,it became apparent that there was a significant positive correlation between IL-37 level and severe CAC (r = 0.360, P 〈 0.001; OR = 1.033)using Spearrnan's correlation and binary logistic regression analysis. Conclusions This study demonstrates that the anti-inflammatory cy-tokine IL-37 is associated with high coronary calcium levels, suggesting that IL-37 expression may be caused by the activation ofinf/amma-tion and that IL-37 might become a predictor of severe CAC in the future, which requires further investigation. | Meng CHAI Hai-Tao ZHANG Yu-Jie ZHOU Qing-Wei JI Qing YANG Yu-Yang LIU Ying-Xin ZHAO Dong-Mei SHI Wei LIU Li-Xia YANG Lin-Lin ZHANC Jing LIANG | 2017 | Journal of Geriatric Cardiology2017，14，5： | 11 |
| 6 | 亚洲近视管理共识显示文摘指南的目标本指南是从国际近视研究所(IMI)白皮书中提取出来的有关近视管理方面的建议[1,2]。本指南所提供的内容都是根据现有最新数据(截至2022年3月)而来,其治疗可行性和执业范围因地区而异,应根据实际情况做调整。眼保健专家组通过对现有最优科学数据进行分析诠释,从而形成了本指南。在工作中,近视管理从业者应该将患者需求放在首位,全面考虑患者具体情况后再提出合适的处理意见。 | Monica Jong Serge Resnikoff Kah Ooi Tan 吕帆 Kah Meng Chung 胡楚南 Ian Morgan Oliver Kam Tong Woo 蓝卫忠 齐备 瞿佳 杨智宽 樊志诚 吴佩昌 Ian Flitcroft Murphy Hian Kee Chan Thok Chuan Tan Charlie Ho David Chai Wong Chong Liang Hwee Koh Olivia Qian Ru Cheng | 2022 | 中华眼视光学与视觉科学杂志2022，24，3： | 11 |
| 7 | Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration显示文摘The capacity of 3D organoids to mimic physiological tissue organization and functionality has provided an invaluable tool to model development and disease in vitro.However,conventional organoid cultures primarily represent the homeostasis of self-organizing stem cells and their derivatives.Here,we established a novel intestinal organoid culture system composed of 8 components,mainly including VPA,EPZ6438,LDN193189,and R-Spondin 1 conditioned medium,which mimics the gut epithelium regeneration that produces hyperplastic crypts following injury;therefore,these organoids were designated hyperplastic intestinal organoids(Hyper-organoids).Single-cell RNA sequencing identified different regenerative stem cell populations in our Hyper-organoids that shared molecular features with in vivo injury-responsive Lgr5+stem cells or Clu+revival stem cells.Further analysis revealed that VPA and EPZ6438 were indispensable for epigenome reprogramming and regeneration in Hyper-organoids,which functioned through epigenetically regulating YAP signaling.Furthermore,VPA and EPZ6438 synergistically promoted regenerative response in gut upon damage in vivo.In summary,our results demonstrated a new in vitro organoid model to study epithelial regeneration,highlighting the importance of epigenetic reprogramming that pioneers tissue repair. | Molong Qu Liang Xiong Yulin Lyu Xiannian Zhang Jie Shen Jingyang Guan Peiyuan Chai Zhongqing Lin Boyao Nie Cheng Li Jun Xu Hongkui Deng | 2021 | Cell Research2021，31，3： | 9 |
| 8 | H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak显示文摘AIM To investigate the protective efficacy ofH2 strain attenuated live hepatitis A vaccines(H2-strain vaccines)in hepatitis A(HA)outbreaks.METHODS With the permission of theirparents,5551 pre-school and grade 1-3 primaryschool children were inoculated with 1 dose(106.5TCID50)of H2-strain vaccines in anonrandomized,controlled trial conducted inFucheng County,Hebei Province in May 1997.Another 6485 children in the same grades andcompatible in gender and age were enrolled ascontrols.Epidemiological and serological surveywas conducted to evaluate the protectiveefficacy of the vaccines.ELISA was used todetect serum IgM anti-HAV.RESULTS HA outbreak started in early May1998,peaked in the middle of the same month,and lasted about 80 days.Overall 302 HA caseswere found,192(53.58%)were 5-9 years old.One vaccinee and 25 control cases were found tohave hepatitis A,which account for 0.28%(1/356)and 5.92%(25/422)of all vaccinees andcontrols in the 14 villages,respectively.The protective efficacy of vaccines was 95.27%(95% Cl:85.83%-104.72%).In subjects testedfor anti-HAV IgM from 13 villages,1(0.40%)overt and 11(4.06%)asymptomatic HAV caseswere found in 271 vaccinees,but 21(6.69%)ofovert and asymptomatic ones were found in 314controls.CONCLUSION H2 strain vaccines were excellent in preventing overt hepatitis A, but not so effective in preventing asymptomatic hepatitis A virus infection. A booster dose might be needed to get permanent reliable immunity. | Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu | 2000 | World Journal of Gastroenterology2000，6，6： | 7 |
| 9 | LC-MS/MS analysis and pharmacokinetic study on five bioactive constituents of Tanreqing injection in rats显示文摘Tanreqing injection(TRQ), a well-known traditional Chinese medicine formula, is commonly used to treat respiratory diseases. In the present study, a rapid, selective, and sensitive liquid chromatography-tandem mass spectrometry(LC-MS/MS) method was developed and validated to simultaneously determinate the plasma contents of 5 major constituents of TRQ, including chlorogenic acid(CHA), caffeic acid(CFA), baicalin(BA), ursodeoxycholic acid(UDCA) and chenodeoxycholic acid(CDCA) in rats after intravenous administration of TRQ. Chromatographic separation was performed on an Agilent Zorbax SB-C_(18) column(3.5 μm, 100 mm × 2.1 mm), with acetonitrile and 0.1% aqueous formic acid as mobile phase at a flow rate of 0.3 m L·min^(^(-1)). The calibration curves were linear over the ranges of 27.0–13 333.0 ng·m L^(-1) for CFA, 30.0–14 933.0 ng·m L^(-1) for CHA, 50.0–50 333.0 ng·m L^(-1) for BA, 550.0–55 000.0 ng·m L^(-1) for UDCA, and 480.0–48 000.0 ng·m L^(-1) for CDCA, respectively. Intra- and inter-day precisions(relative standard deviations, RSDs) were from 3.11% to 14.08%. The extraction recoveries were greater than 71% and accuracy(relative recovery) was from 89% to 137% for all analytes, except endogenous bile acids. This validated method was successfully applied to the first pharmacokinetic study of CFA, CHA, BA, UDCA and CDCA in rat plasma after intravenous administration of TRQ. | ZHANG Feng SUN Liang GAO Shou-Hong CHEN Wan-Sheng CHAI Yi-Feng | 2016 | Chinese Journal of Natural Medicines2016，14，10： | 7 |
| 10 | Harnessing Vis-NIR broad spectrum for photocatalytic CO2 reduction over carbon quantum dots-decorated ultrathin Bi2WO6 nanosheets显示文摘到充满精力的烃燃料的公司 2 的 photocatalytic 减小是探讨附随地的全球温暖和逼近的精力危机的一个有希望、持续的方法。然而,存在光催化剂的一个广阔多数仅仅能够利用紫外(紫外) 或 / 并且可见的光(力) ,而在红外线附近(NIR ) 区域仍然保持未经勘探。在这研究,碳量点(CQD ) 装饰了 ultrathin 双性人 2 WO 6 nanosheets (UBW ) 被表明是为在 Vis-NIR 宽广光谱上的公司 2 光致还原的有效光催化剂。CQDs/UBW 混合 nanocomposites 的合成过程是高度灵巧的,是引人注目的,包含帮助的一个壶 hexadecyltrimethylammonium 溴化物(CTAB ) 热水的过程。在可见轻照耀下面,优化 1CQDs/UBW (1 个 wt.% CQD 内容) 在太古的双性人 24 生产的显著 9.5 褶层和 3.1 褶层改进 > WO 6 nanoplatelets (PBW ) 和赤裸的 UBW 分别地。更重要地, CQDs/UBW 的 photocatalytic 应答成功地被扩大到 NIR 区域,没有包含任何稀土元素或高贵金属,它被完成。减小能被归因于 synergistic 的 驾驶NIR 的公司2的实现(i)完成 ultrathin nanostructures 并且高度暴露了{ 001 } UBW 的活跃方面,( ii ) UBW 和 CQD 的优秀光谱的联合,在 UBW 能由 CQD 的起来变换的光致发光是激动的的地方,并且( iii ) CQD 到的撤退电子的性质套住 photogenerated 电子并且延迟充电搬运人的再结合。 | Xin Ying Kong Wen Liang Tan Boon-Junn Ng Siang-Piao Chai Abdul Rahman Mohamed | 2017 | Nano Research2017，10，5： | 7 |
| 11 | 分级凝胶电解质调控Zn^(2+)配位隧道助力无枝晶锌负极显示文摘本文采用离子交联的方法,制备了高离子限域和氢键增强的单宁酸改性海藻酸基复合凝胶电解质.其中,单宁酸中的酚羟基和海藻酸钠中的羧基可以分别与锌离子进行配位和螯合,有效降低Zn^(2+)溶剂化壳层周围结合水分子的活性,通过增强的离子限域效应抑制了副反应和枝晶的生成,实现了锌的均匀沉积.利用该凝胶电解质组装的Zn/NH_(4)V_(4)O_(10)全电池搁置5d后,在2 A g^(-1)下循环200圈的容量保持率高达97.25%.同时,由于单宁酸中的羰基和海藻酸钠、水分子中的羟基之间形成强分子间氢键相互作用,电池在0℃低温下的循环稳定性也得到明显提升.此外,单宁酸中的酚羟基也可与钒基离子螯合,抑制循环过程中钒的溶解,为抑制钒基正极溶解和提高钒基电池小电流密度下的循环稳定性提供了新的解决方案. | Bingyao Zhang Liping Qin Yun Fang Yizhao Chai Xuesong Xie Bingan Lu Shuquan Liang Jiang Zhou | 2022 | Science Bulletin2022，67，9： | 6 |
| 12 | α→β Transformation characteristics revealed by pulsed laser-induced non-equilibrium microstructures in duplex-phase Zr alloy显示文摘Microstructures of a duplex-phase Zr-2.5Nb alloy treated by pulsed laser were characterized by electron backscatter diffraction(EBSD) and electron channeling contrast(ECC) imaging techniques.Major attention has been paid to non-equilibrium hybrid microstructure consisting of both prior a and β phases,and a plates transformed from new β phases to probe α→β transformation characteristics in the alloy.The origin of the hybrid microstructure is attributed to the specific thermodynamic conditions induced by the pulsed laser treatment.ECC observation shows that newly formed β phases during laser heating prefer to nucleate and grow at the expense of edges of prior a grains rather than their interiors.EBSD analyses further reveal that orientations of the new βphases are not determined by the prior a grains according to the Burgers relationship but maintain those of the prior β phases in an epitaxial growth way. | CHAI LinJiang WANG Shu Yan WU Hao GUO Ning PAN HuCheng CHEN Liang Yu MURTY K.L. SONG Bo | 2017 | Science China(Technological Sciences)2017，60，8： | 5 |
| 13 | Geomorphic features of Quaternary glaciation in the Taniantaweng Mountain, on the southeastern Qinghai-Tibet Plateau显示文摘We present geomorphological evidence for multiple glacial fluctuations during the Quaternary in the Taniantaweng Mountain, which is situated at the transition zone of the southeastern Qinghai-Tibet Plateau and the Yunnan-Guizhou Plateau. To reconstruct the history of glacial evolution during the Quaternary Glaciation, we present a ~13000 km^2 geomorphologic map(1:440,000) for the Quaternary glaciations, as well as three electron spin resonance(ESR) ages and three optically stimulated luminescence(OSL) ages from the landforms. By integrating these with ages from previous studies, four major glacial advances are identified during marine oxygen isotope stages(MIS) 6, 3, 2 and 1. This glacial chronology is in reasonable agreement with existing glacial chronologies from other parts of the Hengduan Mountains and surrounding mountains. Glaciers had extended to the Yuqu River during the glacial maximum advance(MIS 6), but became successively more restricted from MIS 3 to MIS 1. The glacial distribution show that precipitation brought by the south Asian monsoon might play a primary role in driving glacial advances during the last glacial period in the southeastern Qinghai-Tibet Plateau. | ZHANG Wei CHAI Le IAN S.Evans LIU Liang LI Ya-peng QIAO Jing-ru TANG Qian-yu SUN Bo | 2019 | Journal of Mountain Science2019，16，2： | 5 |
| 14 | Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin-1-y1)quinolone derivatives显示文摘A series of novel 7-(4-alkoxyimino-3-hydroxypiperidin-1-yl)quinolone derivatives were designed,synthesized and evaluated for in vitro antibacterial activities.Compounds 8f,8g,8i and 8j with the potencies similar to or better than those of levofloxacin and IMB against Staphylococcus aureus and Staphylococcus epidermidis,worth further investigation. | Wang, Ju Xian Guo, Qiang Chai, Yun Feng, Lian Shun Guo, Hui Yuan Liu, Ming Liang | 2010 | Chinese Chemical Letters2010，21，1： | 4 |
| 15 | Identification of Gesture Based on Combination of Raw sEMG and sEMG Envelope Using Supervised Learning and Univariate Feature Selection显示文摘In this paper,we propose a novel study for gesture identification using surface electromyography(sEMG)signal,and the raw sEMG signal and the sEMG envelope signal are collected by the sensor at the same time.An efficient method of gesture identification based on the combination of two signals using supervised learning and univariate feature selection is implemented.In previous research techniques,researchers tend to use the raw sEMG signal and extract several constant features for classification,which inevitably causes a result of ignoring individual differences.Our experiment shows that both the optimal feature set and redundant feature set are not same for different subjects.In order to address this problem,we extract all the common features from two signals,up to 76 features,most of which has been established as the common EMG-based gesture index.In addition,extracting too many features in an application can reduce operational efficiency,so we apply for feature selection to get the optimal feature set and decrease the number of extracting feature.As a result,the combination of two signals is better than using a single signal.The feature selection can be used to select optimal feature set from all features to achieve the best classification performance for each subject.The experimental results demonstrate that the proposed method achieves the performance with the highest accuracy of 95%for identifying up to nine gestures only using two sensors.Finally,we develop a real-time intelligent sEMG-driven bionic hand system by using the proposed method. | Shili Liang Yansheng Wu Jianfei Chen Ling Zhang Peipei Chen Zongqian Chai Chunlei Cao | 2019 | Journal of Bionic Engineering2019，16，4： | 4 |
| 16 | Novel parameter for assessment of left atrial size in patients with hypertension: ratio of left atrial volume to left ventricular volume显示文摘背景左 atrial 增大作为心脏舒张的机能障碍的一个更柔韧的标记被建议了。我们假设到左室的体积(LAV/LVV ) 的左 atrial 体积的比率可能是更合理的思考,这与高血压在病人离开了 atrial 增大,因为高血压的病人有经常伴有心脏舒张的机能障碍的左室的同心改变的一个特征。学习是决定 LAV/LVV 是否能被用作一个新参数估计的这的目的在在 LAV/LVV 和心脏舒张的 dysfunction.Methods 之间的高血压的病人和关系离开了 atrial 尺寸有高血压和 43 正常控制的 91 个病人被学习。高血压的病人被分到正常的墙(NW ) 和 hypertrophic 墙(HW ) 组。左 atrial 直径(男孩) ,洗室,左 atrial 体积索引(LAVi ) , LVV 和 LAV/LVV 被 2-dimensional echocardiography 和实时 3-dimensional echocardiography 测量并且计算。上述所有参数被用来评估左中庭的尺寸。到侧面的僧帽形的体环(E/E') 的山峰 E' 速度的僧帽形的阀门流入的山峰 E 速度的比率被脉搏 Doppler 和织物 Doppler 测量。这个参数被用来评估心脏舒张的功能。结果在高血压的组的男孩,洗室, LAVi, LAV/LVV 和 E/E' 比在正常的组的那些显著地高(P < 0.05 或 0.01 ) ,并且在 HW 组的那些比在 NW 组的那些显著地高(P < 0.05 或 0.01 ) 。E/E' 与洗室, LAVi 和 LAV/LVV 有积极关联。在 E/E' 和 LAV/LVV 之间的关联系数在 E/E' 之间比那相对高,男孩或 LAVi.Conclusion LAV/LVV 可以被用作一个新索引与心脏舒张的机能障碍在高血压的病人评估左 atrial 尺寸。 | LI Yue CHAI Liang ZHANG Yun LI Lei | 2009 | Chinese Medical Journal2009，，19： | 3 |
| 17 | Association of Plasma Pentraxin-3 Levels on Admission with In-hospital Mortality in Patients with Acute Type A Aortic Dissection显示文摘 | Qin Zhou Xiang-Ping Chai Zhen-Fei Fang Xin-Qun Hu Liang Tang | 2016 | Chinese Medical Journal2016，，21： | 3 |
| 18 | Autonomous Domain Correlation-Based Cross-domain Network View Caching Method for SDN Distributed Controller显示文摘Software-defined networks(SDN) maintain a global view of the network, thus improving the intelligence of forwarding decisions. With the expansion of the network scale, distributed controllers are used in a variety of large-scale networks in which subnetworks managed by controller instance are called autonomous domains. We analyze statistic frequency of communication across the autonomous domain. We calculate the autonomous domain correlations for controller instances using acquired statistical information. We cache network views to highly correlated controller instances. Distributed controllers are capable of considering both the average response time and overall storage. An experiment shows that our method can fully take advantage of these two performance indicators. | FU Tao HU Liang CHAI Sheng CHE Xilong | 2016 | Chinese Journal of Electronics2016，25，6： | 3 |
| 19 | The Malaysian cataract surgery registry:incidence and risk factors of postoperative infectious endophthalmitis over a 7-year period显示文摘AIM:To report the incidence,risk factors and visual outcomes for postoperative endophthalmitis(POE)based on 7-year data from the Malaysian Ministry of Health Cataract Surgery Registry(MOH CSR).METHODS:Data was collected from the web-based MOH CSR.All consecutive cataract surgery patients from 1st June 2008 to 31st December 2014 were identified.Exclusion criteria were traumatic cataract or previous ocular surgery.Demographic data,ocular co-morbidities,intraoperative details and postoperative visual acuity(VA)at final ophthalmological follow-up were noted.All eyes were taken for analysis.Subjects with POE were compared against subjects with no POE for risk factor assessment using multiple logistic regressions.RESULTS:A total of 163 503 subjects were screened.The incidence of POE was 0.08%(131/163 503).Demographic POE risk factors included male gender(OR:2.121,95%CI:1.464-3.015)and renal disease(OR:2.867,95%CI:1.503-5.467).POE risk increased with secondary causes of cataract(OR:3.562,95%CI:1.740-7.288),uveitis(OR:11.663,95%CI:4.292-31.693)and diabetic retinopathy(OR:1.720,95%CI:1.078-2.744).Intraoperative factors reducing POE were shorter surgical time(OR:2.114,95%CI:1.473-3.032),topical or intracameral anaesthesia(OR:1.823,95%CI:1.278-2.602),posterior chamber intraocular lens(PCIOL;OR:4.992,95%CI:2.689-9.266)and foldable IOL(OR:2.276,95%CI:1.498-3.457).POE risk increased with posterior capsule rupture(OR:3.773,95%CI:1.915-7.432)and vitreous loss(OR:3.907,95%CI:1.720-8.873).Postoperative VA of 6/12 or better was achieved in 15.27%(20/131)subjects with POE.CONCLUSION:This study concurs with other studies regarding POE risk factors.Further strengthening of MOH CSR data collection process will enable deeper analysis and optimization of POE treatment. | Yong Zheng Wai Fiona Lee Min Chew Mohamad Aziz Salowi Chai Liang Ang Yong Yuin Chong Tassha Hilda Adnan Pik-Pin Goh | 2018 | International Journal of Ophthalmology(English edition)2018，11，10： | 3 |
| 20 | A small scale expression screen identifies tissue specific markers in the Dugesia japonica strain Pek-1显示文摘Freshwater planaria has tremendous capacity to reform the missing part of the body and therefore is considered as one of the most important model organism for regeneration study. At present, Schmidtea mediterranea and Dugesia japonica are the two major species utilized for laboratory manipulations. Dugesia japonica flatworms are widely distributed in the Far East including Cherry Valley region in the northwest area of Beijing, China. We reported here the establishment of an asexual Dugesia japonica strain Pek1, as a suitable system for regeneration study. Using morphological, karyotypical as well as phylogenetic analyses, we confirmed that these flatworms indeed belonged to Dugesia japonica. We went on to show that the commonly used in situ probes and immunohistochemistry reagents and protocols were applicable to the Pek1 strain. Using this strain, we carried out small scale analysis on EST, RNAi and gene expression. We identified 193 unique EST sequences and 65 of them had not been reported in planarian. By RNAi analysis, we showed that 48 genes, when downregulated individually, had no effect on regeneration. Furthermore, we identified 3 groups of tissue specific expressing genes that were useful for cell lineage analysis. We concluded that the Dugesia japonica Pek1 strain could be another suitable animal model to regeneration research. | Changxin Ma Xiaoan Wang Shuizhou Yu Guoliang Chai Hanxia Su Liang Zheng Wei Wu | 2010 | Journal of Genetics and Genomics2010，37，9： | 3 |
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