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| 1 | New chronological evidence for Yanshanian diagenetic mineralization in China's Altay orogenic belt显示文摘Granitoids and related pegmatitic rare-metal deposits are widespread in China’s Altay region,they used to be considered as Hercynian rocks and mineral deposits.Reported here are the^40Ar^39Ar ages of potassium-rich minerals (muscovite and microcline)in the Koktokay pegmatitic rare-metal orefield and whole-rock as well as quartz fluid-inclusion Rb-Sr isochron ages of granite and ores in the Shangkelan pegmatite rare-metal orefield. The ages indicate that there are Yanshanian Diagenetic Mineralization events happening in China’s Altay orogenic belt and that formation of the famous Koktokay No.3 pegmatitic rare-metal deposit endured about 30 Ma of magmatic crystallization differentiation. | Fuwen Chen Huaqin Li Denghong Wang Hong Cai Wen Chen | 2000 | Chinese Science Bulletin2000，45，2： | 12 |
| 2 | EMBRYONIC FACTOR 19 Encodes a Pentatricopeptide Repeat Protein that is Essential for the Initiation of Zygotic Embryogenesis in Arabidopsis显示文摘Early embryogenesis is the most fundamental developmental process in biology.Screening of ethyl methanesulfonate(EMS)-mutagenized populations of Arabidopsis thaliana led to the identification of a zygote-lethal mutant embryonic factor 19(fac19)in which embryo development was arrested at the elongated zygote to octant stage.The number of endosperm nuclei decreased significantly in fac19 embryos.Genetic analysis showed fac19 was caused by a single recessive mutation with typical mendelian segregation,suggesting equal maternal and paternal contributions of FAC19 towards zygotic embryogenesis.Positional cloning showed that FAC19 encodes a putative mitochondrial protein with 16 conserved pentatricopeptide repeat(PPR)motifs.The fac19 mutation caused a conversion from hydrophilic serine located in a previously unknown domain to hydrophobic leucine.Crosses between FAC19/fac19 and the T-DNA insertion mutants in the same gene failed to complement the fac19 defects,confirming the identity of the gene.This study revealed the critical importance of a PPR protein-mediated mitochondrial function in early embryogenesis. | Dali Yu Li Jiang Huaqin Gong Chun-Ming Liu | 2012 | Journal of Integrative Plant Biology2012，54，1： | 8 |
| 3 | Effect of Ti substitution on hydrogen storage properties of Zr_(1-x)Ti_xCo (x = 0, 0.1, 0.2, 0.3) alloys显示文摘Zr1-xTixCo(x = 0, 0.1, 0.2, 0.3) alloys were prepared by arc-melting method and the effect of Ti substitution on hydrogen storage properties was studied systematically. Hydrogen desorption pressure-composition-temperature(PCT) measurements were carried out using Sievert's type volumetric apparatus for ZrCo(at 473 K, 573 K and 673 K) and Zr1-xTixCo alloys(at 673 K), respectively. Products after dehydrogenation were characterized by X-ray diffraction(XRD). In addition, the kinetics of Zr1-xTixCo hydride was investigated at 473 K and 673 K,respectively, under hydrogen pressure of 5 MPa. Results showed that Ti substitution for Zr did not change the crystal structure of ZrCo phase.With the increase of temperature from 473 K to 673 K, the extent of disproportionation for ZrCo alloy increased. With Ti content increasing at 673 K, the desorption equilibrium pressure of Zr1-xTixCo-H2 systems elevated and the disproportionation reaction of Zr1-xTixCo alloys was inhibited effectively. Ti substitution decreased the kinetics rate and the effective hydrogen storage capacity of Zr1-xTixCo alloys slightly.Generally speaking, it was found that Zr0.8Ti0.2Co alloy had better anti-disproportionation property with less decrease of effective hydrogen storage capacity which was beneficial to tritium application in the International Thermonuclear Experimental Reactor(ITER). | Yamin Zhao Rongfeng Li Ruihe Tang Boyan Li Ronghai Yu Wei Liu Huaqin Kou Jianbo Meng | 2014 | Journal of Energy Chemistry2014，23，1： | 6 |
| 4 | Sm-Nd and Rb-Sr isotopical ages of magnetite-chlorite formation gold deposit in the volcanic rock area of Late Paleozoic Era,East Tianshan显示文摘Through studying geo-geochemical characteristics and determining Sm-Nd and Rb-Sr isotopical ages in the Kanggur magnetite-chlorite formation gold deposit, some conclusions can be achieved: Sm-Nd isochron age is (290.4 ±7)Ma, Rb-Sr isochron age is (282.3 ±5)Ma, mineralization is Late Hercynian and the formation of this gold deposit is related to the macro- | Jinsheng Ji Huaqin Li Lianchang Zhang Xingke Yang Chengyou Feng | 1999 | Chinese Science Bulletin1999，44，19： | 5 |
| 5 | Significance of VEGF and NF-κB Expression in Thyroid Carcinoma显示文摘OBJECTIVE To investigate the significance of vascular endothelial growth factor (VEGF) and nuclear factor-kappaB (NF-κB) expression in thyroid carcinoma. METHODS The expression of NF-κB and VEGF was determined by im- munohistochemistry in formalin-fixed and paraffin-embedded specimens obtained from 10 normal thyroid tissues (NT), 12 cases of thyroid adeno- ma (TA) and 68 cases of thyroid carcinoma (TC).Differences in expres- sion between NT, TA and TC were statistically analyzed. In addition, in cases of TC, the relationship of NF-κB and VEGF expression with various clinicopathological factors, including histological typing, clinical staging and lymph node metastasis, as well as the correlation between N F - κ B and VEGF expression was examined. RESULTS In contrast to the negative immunoreactivity for VEGF in NT, there was a significantly higher positive incidence (PI) in TA (41.7%, P= 0.040) and TC (75.0%, P<0.001), and a significant difference between TA and TC (P=0.036). Immunoreactivity for NF-κB in NT was negative and significantly higher in TC (63.2%, P<0.001),but not in TA (16.7%, P= 0.481). However the PI difference between TA and TC (P=0.003) was significant. Between the histological types of TC, a significantly higher PI was found in undifferentiated thyroid carcinoma (UTC),namely,100% for VEGF and 90.0% for NF-κB. We also found significant positive relation- ships of VEGF and N F - κ B expression with the clinical stage and lymph node metastasis. Furthermore, a significant positive correlation between VEGF and NF-κB expression in TC was observed. CONCLUSION Our data showed that the expression of VEGF and NF- ΚB/P65 was greater in TC and UTC, and documented their significant positive correlations with the clinical stage and lymph node metastasis in TC. In addition there was a significant positive relationship between their expression, suggesting that they have important roles in TC and that they may be potential targets for gene therapy in TC patients. | Zhenxian Du Haiyan Zhang Daxin Gao Huaqin Wang Yongjun Li Guoliang Liu | 2006 | Chinese Journal of Clinical Oncology2006，3，3： | 3 |
| 6 | Numerical Modeling of Floating Oil Boom Motions in Wave-Current Coupling Conditions显示文摘Containment booms are commonly used in collecting and containing spilled oil on the sea surface and in protecting specific sea areas against oil slick spreading.In the present study,a numerical model is proposed based on the N-S equations in a mesh frame.The proposed model tracks the outline of the floating boom in motion by using the fractional area/volume obstacle representation technique.The boom motion is then simulated by the technique of general moving object.The simulated results of the rigid oil boom motions are validated against the experimental results.Then,the failure mechanism of the boom is investigated through numerical experiments.Based on the numerical results,the effects of boom parameters and dynamic factors on the oil containment performance are also assessed. | SHI Yang LI Shaowu ZHANG Huaqin PENG Shitao CHEN Hanbao ZHOU Ran MAO Tianyu | 2017 | Journal of Ocean University of China2017，16，4： | 2 |
| 7 | Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer显示文摘 | Peifen Cai Wenjie Guo HuaQin Yuan Qian Li Weicheng Wang Yang Sun Xiaomin Li Yanhong Gu | 2013 | Biomedicine & Pharmacotherapy2013，，： | 1 |
| 8 | Mineralization and fluid inclusion study of the Shizhuyuan W-Sn-Bi-Mo-F skarn deposit, Hunan Province, China 显示文摘 | Lu Huan-zhang Liu Yimiao Wang Changlie Xu Youzhi Li Huaqin | 2003 | Econ Geol2003，98，5： | 1 |
| 9 | Melt index prediction by adaptively aggregated RBF neural networks trained with novel ACO algorithm显示文摘 | Jiubao Li Xinggao Liu Huaqin Jiang Yundu Xiao | 2011 | Journal of Applied Polymer Science2011，10，2： | 1 |
| 10 | Effects of fluoride additives on dehydrogenation behaviors of2LiBH4-MgH2system显示文摘 | KOU Huaqin XIAO Xuezhang LI Jinxiu | 2012 | Int J Hydrogen Energ2012，37，1： | 1 |
| 11 | Regulating local chemistry in ZrCo-based orthorhombic hydrides via increasing atomic interference for ultra-stable hydrogen isotopes storage显示文摘Developing a universal and reliable strategy for the modulation of composition and structure of energy storage materials with stable cycling performance is vital for hydrogen and its isotopes storage advanced system,yet still challenging.Herein,an ultra-stable lattice structure is designed and verified to increase atomic chaos and interference for effectively inhibiting disproportionation reaction and improving cycling stability in ZrCo-based hydrogen isotopes storage alloy.After screening in terms of configuration entropy calculation,we construct Zr_(1-2)Nb_(x)Co_(1-2x)Cu_(x)Ni_(x)(x=0.15,0.2,0.25) alloys with increased atomic chaos,and successfully achieve stable isostructural de-/hydrogenation during 100 cycles,whose cycling capacity retentions are above 99%,much higher than 22.4%of pristine ZrCo alloy.Both theoretical analysis and experimental evidences indicate the high thermo-stability of orthorhombic lattice in Zr_(0.8)Nb_(0.2)Co_(0.6)Cu_(0.2)Ni_(0.2) alloy.Notably,the increased atomic chaos and interference in Zr_(0.8)Nb_(0.2)Co_(0.6)Cu_(0.2)Ni_(0.2) alloy causes regulation in hydrogen local chemical neighborhood,thereby confusing the hydrogen release order,which effectively eliminates lattice distortion and unlocks an ultrastable lattice structure.This study provides a new and comprehensive inspiration for hydrogen atoms transport behaviors and intrinsic reason of stable orthorhombic transformation,which can contribute to paving the way for other energy storage materials modulation. | Zhaoqing Liang Zhendong Yao Ruhong Li Xuezhang Xiao Zhichao Ye Xuancheng Wang Jiacheng Qi Jiapeng Bi Xiulin Fan Huaqin Kou Wenhua Luo Changan Chen Lixin Chen | 2022 | Journal of Energy Chemistry2022，31，6： | 0 |
| 12 | Multiplex genome editing targeting soybean with ultra-low anti-nutritive oligosaccharides显示文摘Soybean is the primary source of plant protein for humans.Owing to the indigestibility of the raffinose family of oligosaccharides(RFO),raffinose and stachyose are considered anti-nutritive factors in soybean seeds.Low-RFO soybean cultivars are generated by mutagenesis of RFO biosynthesis genes,but the carbohydrate profiles invite further modification to lower RFOs.This study employed a pooled multiplex genome editing approach to target four seed-specifically expressed genes mediating RFO biosynthesis,encoding three raffinose synthases(RS2,RS3,and RS4)and one stachyose synthase.In T1progeny,rs2/rs3 and rs4/sts homozygous double mutants and a rs2/rs3/rs4/sts quadruple mutant(rfo-4m)were characterized.The rs2/rs3 mutant showed reduced raffinose and stachyose contents,but the rs4/sts mutant showed only reduced stachyose in seeds.The RFO contents in the rfo-4m mutant were almost eliminated.Metabolomic analysis showed that the mutation of four RFO biosynthesis genes led to a shift of metabolic profile in the seeds,including the accumulation of several oligosaccharides-related metabolites.These mutants could contribute to precision breeding of soybean cultivars for soy food production. | Wenxin Lin Huaqin Kuang Mengyan Bai Xiaomeng Jiang Pengfei Zhou Yinghua Li Bo Chen Huarong Li Yuefeng Guan | 2023 | The Crop Journal2023，11，3： | 0 |
| 13 | Expressing a human RNA demethylase as an assister improves gene-editing efficiency in显示文摘Dear Editor,Despite myriad successful applications of gene editing in plant functional genomics research and precision breeding,many challenges persist around the efficiency of gene-editing tools for many plant species.For instance,soybean(Glycine max)is a major crop providing oil and protein to human diets and feedstock,but its gene-editing efficiency remains relatively low(Bai et al.,2019). | Mengyan Bai Wenxin Lin Chunyan Peng Peizhe Song Huaqin Kuang Jieni Lin Jieping Zhang Jiyao Wang Bo Chen Huarong Li Fanjiang Kong Guifang Jia Yuefeng Guan | 2024 | Molecular Plant2024，17，3： | 0 |
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