|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Research progress of monitoring, forecasting, and prevention of rockburst in underground coal mining in China显示文摘As one of the dynamic disasters of coal mines,rockburst seriously affects underground safe coal mining.Based on the laboratory test,field test,and theoretical analysis,this study proposed the principle of the rock burst induced by the combination of dynamic and static stresses and divided such rock burst into three types,including induced by primary dynamic stress,mainly induced by dynamic stress,and by dynamic stress in low critical stress state.The expressions of the static stress induced by coal mining and dynamic stress induced by mining tremors were obtained.Moreover,theories and technologies at home and abroad were summarized concerning the monitoring,forecasting,and preventing of rockburst.These mainly include the zoning and leveling forecasting method,electromagnetic radiation technology,elastic wave and seismic wave computed tomography technologies in aspect of rockburst monitoring,as well as the intensity weakening theory,the strong-soft-strong structure effect,the directional hydraulic fracturing technology,the roadway support system in regards of rockburst prevention.The prospect of rockburst development suggested that researches concerning the rockburst mechanism should be quantitatively developed around the roadway and coalface surrounding coal-rock mass.It should be focused on the rockburst mechanism and prevention technology of mining with over 1,000 km deep and mining in large tectonic zone.In addition,the monitoring and prevention of rockburst should be based on rockburst mechanism. | Linming Dou Zonglong Mu Zhenlei Li Anye Cao Siyuan Gong | 2014 | International Journal of Coal Science & Technology2014，1，3： | 64 |
| 2 | Numerical Simulation and Analysis of Solid-liquid Two-phase Flow in Centrifugal Pump显示文摘The flow with solid-liquid two-phase media inside centrifugal pumps is very complicated and the relevant method for the hydraulic design is still immature so far.There exist two main problems in the operation of the two-phase flow pumps,i.e.,low overall efficiency and severe abrasion.In this study,the three-dimensional,steady,incompressible,and turbulent solid-liquid two-phase flows in a low-specific-speed centrifugal pump are numerically simulated and analyzed by using a computational fluid dynamics(CFD) code based on the mixture model of the two-phase flow and the RNG k-two-equation turbulence model,in which the influences of rotation and curvature are fully taken into account.The coupling between impeller and volute is implemented by means of the frozen rotor method.The simulation results predicted indicate that the solid phase properties in two-phase flow,especially the concentration,the particle diameter and the density,have strong effects on the hydraulic performance of the pump.Both the pump head and the efficiency are reduced with increasing particle diameter or concentration.However,the effect of particle density on the performance is relatively minor.An obvious jet-wake flow structure is presented near the volute tongue and becomes more remarkable with increasing solid phase concentration.The suction side of the blade is subject to much more severe abrasion than the pressure side.The obtained results preliminarily reveal the characteristics of solid-liquid two-phase flow in the centrifugal pump,and are helpful for improvement and empirical correction in the hydraulic design of centrifugal pumps. | ZHANG Yuliang LI Yi CUI Baoling ZHU Zuchao DOU Huashu | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 55 |
| 3 | Effect of pre-procedural statin therapy on myocardial no-reflow following percutaneous coronary intervention: a meta analysis显示文摘 | LI Xiang-dong YANG Yue-jin HAO Yong-chen YANG Ying ZHAO Jing-lin DOU Ke-fei GU Dong-feng | 2013 | Chinese Medical Journal2013，，9： | 35 |
| 4 | Intravenous injection of mesenchymal stem cells is effective in treating liver fibrosis显示文摘AIM: To compare the influence of different transplant sites in bone marrow mesenchymal stem cell (MSC)-based therapy for liver fibrosis. METHODS: MSCs isolated from Sprague Dawley (SD) rats were induced into hepatocyte-like cells. Liver fibrosis in SD rats was induced with carbon tetrachloride. Following hepatocyte induction in vitro, 4',6-diamidino- 2-phenylindole (DAPI)-labeled MSCs were transplanted by intravenous, intrahepatic, and intraperitoneal injection. Histopathological staining, immunohistochemistry, and biochemical analysis were used to compare the morphological and functional liver regeneration among different MSC injection modalities. The expression differences of interleukins, growth factor, extracellular matrix, matrix metalloproteinases, and tissue inhibitor of metalloproteinase were examined by real-time reverse transcription-polymerase chain reaction (RT-PCR) andenzyme linked immunosorbent assay (ELISA). RESULTS: Four days after exposure to hepatocyte differentiation medium, MSCs that did not express hepatocyte markers could express α-fetoprotein, albumin, and cytokeratin 18. The results of histopathological staining, immunohistochemistry, and biochemical analysis indicated that intravenous injection is more effective at rescuing liver failure than other injection modalities. DAPI-labeled cells were found around liver lobules in all three injection site groups, but the intravenous group had the highest number of cells. PCR and ELISA analysis indicated that interleukin-10 (IL-10) was highest in the intravenous group, whereas il1β, il6, tnfα and tgfβ, which can be regulated by IL10 and are promoters of liver fibrosis, were significantly lower than in the other groups. CONCLUSION: MSC administration is able to protect against liver fibrosis. Intravenous injection is the most favorable treatment modality through promotion of IL10 expression. | Wei Zhao Jun-Jie Li Da-Yong Cao Xiao Li Lin-Ying Zhang Yong He Shu-Qiang Yue De-Sheng Wang Ke-Feng Dou | 2012 | World Journal of Gastroenterology2012，18，10： | 32 |
| 5 | Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging for predicting histological grade of hepatocellular carcinoma:Comparison with conventional diffusion-weighted imaging显示文摘AIM To compare intravoxel incoherent motion(IVIM)-derived parameters with conventional diffusion-weighted imaging(DWI) parameters in predicting the histological grade of hepatocellular carcinoma(h CC) and to evaluate the correlation between the parameters and the histological grades.METHODS A retrospective study was performed. Sixty-two patients with surgically confirmed h CCs underwent diffusion-weighted magnetic resonance imaging with twelve b values(10-1200 s/mm^2). The apparent diffusion coefficient(ADC), pure diffusion coefficient(D), pseudo-diffusion coefficient(D*), and perfusion fraction(f) were calculated by two radiologists. The IVIM and conventional DWI parameters were compared among the different grades by using analysis of variance(ANOVA) and the Kruskal-Wallis test. Receiver operating characteristic(ROC) analysis was performed to evaluate the diagnostic efficiency of distinguishing between low-grade(grade 1, G1) and high-grade(grades 2 and 3, G2 and G3) hC C. The correlation between the parameters and the histological grades was assessed by using the Spearman correlation test. Bland-Altman analysis was used to evaluate the reproducibility of the two radiologists' measurements.RESULTS The differences in the ADC and D values among the groups with G1, G2, and G3 histological grades of HCCs were statistically significant(P < 0.001). The D* and f values had no significant differences among the different histological grades of h CC(P > 0.05). The ROC analyses demonstrated that the D and ADC values had better diagnostic performance in differentiating the low-grade h CC from the high-grade h CC, with areas under the curve(AUCs) of 0.909 and 0.843, respectively, measured by radiologist 1 and of 0.911 and 0.852, respectively, measured by radiologist 2. The following significant correlations were obtained between the ADC, D, and D~* values and the histological grades: r =-0.619(P < 0.001), r =-0.628(P < 0.001), and r =-0.299(P = 0.018), respectively, as measured by radiologist 1; r =-0.622(P < 0.001), r =-0.633(P < 0.001), and r =-0.303(P = 0.017), respectively, as measured by radiologist 2. The intra-class correlation coefficient(ICC) values between the two observers were 0.996 for ADC, 0.997 for D, 0.996 for D*, and 0.992 for f values, which indicated excellent interobserver agreement in the measurements between the two observers.CONCLUSION The IVIM-derived D and ADC values show better diagnostic performance in differentiating high-grade hC C from low-grade hC C, and there is a moderate to good correlation between the ADC and D values and the histological grades. | Shao-Cheng Zhu Yue-Hua Liu Yi Wei Lin-Lin Li She-Wei Dou Ting-Yi Sun Da-Peng Shi | 2018 | World Journal of Gastroenterology2018，24，8： | 33 |
| 6 | Relationship of hepatitis B virus infection of placental barrier and hepatitis B virus intra-uterine transmission mechanism显示文摘AIM: To explore the mechanism of intra-uterine transmission,the HBV infection status of placental tissue and in vitro cultured placental trophoblastic cells was tested through in vivo and in vitro experiments. METHODS: A variety of methods,such as ELISA,RT- PCR,IHC staining and immunofluorescent staining were employed to test the HBV marker positive pregnant women's placenta and in vitro cultured placental trophoblastic cells. RESULTS: The HBV DNA levels in pregnant women's serum and fetal cord blood were correlated. For those cord blood samples positive for HBV DNA,their maternal blood levels of HBV DNA were at a high level. The HBsAg IHC staining positive cells could be seen in the placental tissues and the presence of HBV DNA detected. After co-incubating the trophoblastic cells and HBV DNA positive serum in vitro,the expressions of both HBsAg and HBV DNA could be detected. CONCLUSION: The mechanism of HBV intra-uterine infection may be due to that HBV breaches the placental barrier and infects the fetus. | Han Bai Lin Zhang Li Ma Xiao-Guang Dou Guo-He Feng Gui-Zhen Zhao | 2007 | World Journal of Gastroenterology2007，13，26： | 30 |
| 7 | Effect of Bcl-2 and Bax on survival of side population cells from hepatocellular carcinoma cells显示文摘AIM: To understand the role and significance of side population (SP) cells from hepatocellular carcinoma (HCC) in hepatocarcinogenesis, development, relapse and metastasis, we simulated the denutrition conditions that cancer cells experience in clinical therapy, observed the different anti-apoptosis ability of SP cells and non-SP cells under such conditions, and established the possible effects of P53, Bcl-2 and Bax on survival of SP cells. METHODS: We used ? ow cytometry to analyze and sort the SP and non-SP cells in established HCC lines MHCC97 and hHCC. We evaluated cell proliferation by methyl thiazolyl tetrazolium (MTT) assay and investigated the expression of p53, bcl-2 and bax genes during denutrition, by RT-PCR and immuno? uorescence staining. RESULTS: The percentage of SP cells in the two established HCC lines was 0.25% and 0.5%, respectively. SP cells had greater anti-apoptosis and proliferation ability than non-SP cells. Expression of Bcl-2 and Bax in SP and non-SP cells differed during denutrition. The former was up-regulated in SP cells, and the latter was up-regulated in non-SP cells. CONCLUSION: It may be that different upstream molecules acted and led to different expression levels of Bcl-2 and Bax in these two cell lines. There was a direct relationship between up-regulation of Bcl-2 and down-regulation of Bax and higher anti-apoptosis ability in SP cells. It may be that the existence and activity of SP cells are partly responsible for some of the clinical phenomena which are seen in HCC, such as relapse or metastasis. Further research on SP cells may have potential applications in the f ield of anticancer therapy. | Jing Fan Ren Li Rui Zhang Hai-Liang Liu Ning Zhang Fu-Qing Zhang Ke-Feng Dou | 2007 | World Journal of Gastroenterology2007，13，45： | 27 |
| 8 | Isolation and Identification of Cancer Stem-Like Cells from Murine Melanoma Cell Lines显示文摘In current study,cancer stem-like cells in the murine melanoma B16F10 cells were investigated.CD phenotypes of the B16F10 cells were analyzed by flow cytometry,and the specific CD phenotype cells from the B16F10 cells were isolated by MACS.Then we used colony formation assay in soft agar media,the cell growth assay in serum-free culture media as well as the tumorigenicity investigation of the specific CD phenotype cells in C57BL/6 mice, respectively,to identify cancer stem-like cells in the B16F10 cells.The results showed that the B16F10 cells could form spherical clones in serum-free culture media,and the rate of clonegenesis of CD133 + ,CD44 + and CD44 + CD133 + cells was higher than that of CD133 - ,CD44 - and CD44 + CD133 - cells in soft agar media,respectively. The tumorigenic potential of CD133 + ,CD44 + ,CD44 + CD133 + cells and CD44 + CD133 + CD24 + cells was stronger than that of CD133 - ,CD44 - ,CD44 + CD133 - cells and CD44 + CD133 + CD24 - cells in mice,respectively.In conclusion,the CD44 + CD133 + CD24 + cells have some biological properties of cancer stem-like cells or are highly similar to the characteristics of cancer stem cells(CSC).These results provide an important method for identifying cancer stem-like cells in B16F10 cells and for further cancer target therapy. | Jun Dou Meng Pan Ping Wen Yating Li Quan Tang Lili Chu Fengshu Zhao Chuilian Jiang Weihua Hu Kai Hu Ning Gu | 2007 | Cellular & Molecular Immunology2007，4，6： | 25 |
| 9 | Preparation and microstructure characterization of a nano-sized Ti^(4+)-doped AgSnO_2 electrical contact material显示文摘A Ti4+-doped nano-structured AgSnO2 material was prepared using sol-gel method and characterized by X-ray diffraction (XRD), transmis-sion electron microscopy (TEM), and scanning electron microscopy (SEM). The results show that Ti4+ cations are successfully doped into the crystal lattice of SnO2, and thus significantly improve the electrical conductivity of the sample. Furthermore, the coating of Ag on Ti4+-doped SnO2 nano-sized particles enhances the surface wettability and enables the resulting AgSnO2 material to have better mechanical properties. | ZHENG Ji LI Songlin DOU Fuqi LI Tonghui | 2009 | Rare Metals2009，28，1： | 24 |
| 10 | Analysis of observations on the urban surface energy balance in Beijing显示文摘1 年(20092010 ) 大小从在一个 325-m 塔的三垂直的层位于闹市区北京的传感器获得的城市的表面精力平衡(SEB ) 被分析。结果显示出那:(1 ) 从 325-m 塔的大小代表位于半潮湿的温暖适度的大陆人季风气候地区的城市的 SEB 特征。在典型热、多雨的夏天,感冒和干燥冬季,测量鲍恩比率在冬季在夏天和最大值是最小的。在 140 m 测量春天,夏天,秋天,和冬季的鲍恩比率分别地是 2.86, 0.82, 1.17,和 4.16。(2 ) 在 140-m 的高度(在经常的流动层) ,中午反照率是 0.10 夏天, 0.12 为春天和秋天,并且 0.14 为冬季。白天的比率理智的热流动,潜伏的热流动,和捕捞放射的存储热流动是 0.25, 0.16,和 0.59 清楚天空的天,并且 0.33, 0.19,和 0.48 为多云的天分别地。(3 ) 在清楚天空的天下面,夜间理智的热流动是几乎零,但是潜伏的热流动比零大。为多云的天,夜间理智的热流动比在冬季的潜伏的热流动稍微大。向上的热流动是的夜间大概由于人为的版本(为夏天的主要潜伏的热,当时为冬季的潜伏、理智的热) 。 | MIAO ShiGuang DOU JunXia CHEN Fei LI Ju LI AiGuo | 2012 | Science China Earth Sciences2012，55，11： | 23 |
| 11 | Cycloastragenol upregulates SIRT1 expression,attenuates apoptosis and suppresses neuroinflammation after brain ischemia显示文摘Cycloastragenol(CAG)is the active form of astragaloside V isolated from Astragalus Radix,which displays multiple pharmacological effects.Silent information regulator 1(SIRT1),a classll histone deacetylase,has been shown to play an important role in neuroprotection against cerebral ischemia.In this study,we investigated whether CAG protected against ischemic brain injury and,if so,whether the beneficial effects were associated with the regulation of SIRT1 in the ischemic brain.Mice were subjected to 45 min of middle cerebral artery occlusion(MCAO)followed by reperfusion.CAG(5,10,20 mg/kg)was injected intraperitoneally at the onset of reperfusion,12h later and then twice daily for up to three days.CAG dose-dependently reduced brain infarct volume,significantly ameliorated functional deficits,and prevented neuronal cell oss in MCAO mice.Meanwhile,CAG signicantly reduced matrix metalloproteinase-9 activity,prevented tight junction degradation and subsequently ameliorated blood-brain barier disruption.Moreover,CAG significantly upregulated SIRT1 expression in the ischemic brain but did not directly activate its enzymatic activity.Concomitant with SIRT1 upregulation,CAG reduced p53 acetylation and the ratio of Bax to Bcl-2 in the ischemic brain.CAG also inhibited NF-κB p65 nuclear translocation.As a result,CAG suppressed the mRNA expression of pro-inflammatory cytokines,including TNF-α and IL-1β,and inhibited the activation of microglia and astrocytes in the ischemic brain.Our findings suggest that CAG is neuroprotective against ischemic brain injury in mice and that its beneficial effect may involve SIRT1 upregulation and the inhibition of apoptosis and neuroinflammation in the ischemic brain. | Man Li Shichun Li Bao-kai Dou Yving-xiang Zou Hao-zhen Han Dong-xiang Liu Zunji Ke Zhi-fei Wang | 2020 | Acta Pharmacologica Sinica2020，41，8： | 22 |
| 12 | Clinical significance of diabetes on symptom and patient delay among patients with acute myocardial infarction——an analysis from China Acute Myocardial Infarction(CAMI) registry显示文摘Background Diabetes is frequently associated with poor prognosis among acute myocardial infarction(AMI)patients.Patients with these comorbidities often have atypical symptoms and subsequent delay in treatment.Few studies have reported detailed AMI symptoms in patients with diabetes.This study compared AMI symptoms and presentation characteristics between diabetics and non-diabetics.Methods We included patients from the China AMI registry diagnosed with AMI between January 2013 and September 2014.Baseline characteristics,symptomology,and delay in treatment were compared between diabetics and non-diabetics.Multivariable logistic regression analysis was used to explore independent predictors of atypical symptoms.Results A total of 4450(20.2%)patients had diabetes.They were older,more often women,higher in body mass index,and more likely to have non-ST segment elevation myocardial infarction.Fewer diabetic patients presented with persistent precordial chest pain(63.1%vs.68%,P<0.0001),diaphoresis(60.1%vs.65.6%,P<0.0001),fatigue(16.7%vs.18.3%,P=0.0123),and incontinence(0.4%vs.0.7%,P=0.0093).Time to hospital presentation was longer among patients with diabetes than those without.In multivariable analysis,diabetes was identified as an independent predictor of atypical symptoms(OR:1.112,95%CI:1.034?1.196).Conclusions Our study is the first large-scale study providing evidence that diabetics are less likely to present with typical chest pain and more likely to experience treatment delay when suffering from an AMI.Our results may increase clinician awareness of recognizing AMI patients rapidly to reduce diagnosis and treatment delay,particularly in the context of diabetes. | Rui FU Si-Dong LI Chen-Xi SONG Jing-Ang YANG Hai-Yan XU Xiao-Jin GAO Yi XU Jian-Ping ZENG Jun-Nong LI Ke-Fei DOU Yue-Jin YANG on behalf of the CAMI Registry study group Beijing,China | 2019 | Journal of Geriatric Cardiology2019，16，5： | 21 |
| 13 | Determining "abnormal" levator hiatus distensibility using three-dimensional transperineal ultrasound in Chinese women显示文摘The dimension of the levator hiatus is a possible predictor of pelvic organ prolapse (POP). Thisretrospective study investigated 360 women who went to urogynecological clinic for pelvic floor discomfort.Levator hiatus dimensions were obtained by three-dimensional transperineal ultrasound and results werecompared between women with and without significantly objective prolapse (International Continence SocietyPOP quantification, grade 2 or higher). Receiver operating characteristic (ROC) curve analyses were performed todetermine valid screening index for detecting abnormal levator hiatus distensibility. Women with significantlyobjective prolapse had significantly higher levator hiatus dimensions than those without (all P 〈 0.001). ROCcurve analyses confirmed that hiatal area (HA) of 19.5 cm2 during Valsalva maneuver can be used as single-screening index for abnormal levator hiatus distensibility with sensitivity of 0.80 and specificity of 0.70. In thisstudy, we used a two-step method and achieved higher sensibility (0.80 vs. 0.87) without reducing specificity (0.70vs. 0.71) compared with a single-screening index method. As a result, we suggest that HA ≥ 19.5 cm2 duringValsalva maneuver is an indicator of abnormal levator hiatus distensibility in Chinese women and that the two-step method has higher sensitivity in detecting abnormal distensibility. | Chaoran Dou Qin Li Tao Ying Yulin Yan Xia Wang Bing Hu | 2018 | Frontiers of Medicine2018，12，5： | 21 |
| 14 | Experimental investigation into stress-relief characteristics with upward large height and upward mining under hard thick roof显示文摘 | Ke Yang Xiang He Litong Dou Wenjun Liu Li Sun Haisong Ye | 2015 | International Journal of Coal Science & Technology2015，2，1： | 20 |
| 15 | Effects of Tongxinluo-facilitated cellular cardiomyoplasty with autologous bone marrow-mesenchymal stem cells on postinfarct swine hearts显示文摘<正> Background Treatment of ischemic heart disease remains an important challenge,though there have been enormousprogresses in cardiovascular therapeutics.This study was conducted to evaluate whether Tongxinluo(TXL)treatmentaround the transplantation of mesenchymal stem cells(MSCs)can improve survival and subsequent activities ofimplanted cells in swine hearts with acute myocardial infarction(AMI)and reperfusion.Methods Twenty-eight Chinese mini-pigs were divided into four groups including a control group(n=7);group 2,administration of low-dose TXL alone from the 3rd day prior to AMI to the 4th day post transplantation(n=7);group 3,MSCs alone(n=7)and group 4,TXL+MSCs(n=7).AMI models were made by occlusion of the left anterior descendingcoronary artery for 90 minutes.Autologous bone marrow-MSCs(3×10~7 cells/animal)were then injected into thepost-infarct myocardium immediately after AMI and reperfusion.The survival and differentiation of implanted cells in vivowere detected by immunofluorescent analysis.The data of cardiac function were obtained at baseline(1 week aftertransplantation)and endpoint(6 weeks after transplantation)by single photon emission computed tomography(SPECT)and magnetic resonance imaging(MRI).Apoptosis was detected by TUNEL assay and the oxidative stress level wasinvestigated in the post-infarct myocardium at endpoint.Results At endpoint,there was less fibrosis and inflammatory cell infiltration with more surviving myocardium in group 4than in the control group.In group 4 the survival and differentiation of implanted MSCs were significantly improved morethan that seen in group 3 alone(P<0.0001);the capillary density was also significantly greater than in the control group,group 2 or 3 both in the infarcted zone(P<0.0001)and the peri-infarct zone(P<0.0001).MRI showed that parameters atbaseline were not significantly different between the 4 groups.At endpoint,regional wall thickening and the left ventricularejection fraction were increased while the left ventricular mass index,dyskinetic segments and infarcted size weredecreased only in group 4 compared with control group(P<0.0001).SPECT showed that the area of perfusion defectwas significantly decreased at endpoint only in group 4 compared with control group(P<0.0001).TUNEL assay indicatedthat TXL administration significantly decreased cell apoptosis in peri-infarct myocardium in groups 2 and 4.Furthermore,superoxide dismutase(SOD)significantly increased and malondialdehyde(MDA)decreased in groups 2 and 4 by theadministration of TXL.Conclusions Our study demonstrates the following:(1)immediate intramyocardial injection of MSCs after AMI andreperfusion resulted in limited survival and differentiation potential of implanted cells in vivo,thus being incapable ofbeneficially affecting post-hearts;(2)TXL-facilitation resulted in a significant survival and differentiation potential ofimplanted cells in vivo via inhibition of apoptosis and oxidative stress,accompanied by significant benefits in cardiacfunction.Chin Med J 2007;120(16) | QIAN Hai-yan YANG Yue-jin HUANG Ji GAO Run-lin DOU Ke-fei YANG Guo-sheng LI Jian-jun SHEN Rui HE Zuo-xiang LU Min-jie ZHAO Shi-hua | 2007 | Chinese Medical Journal2007，，16： | 19 |
| 16 | Randomized controlled trial: Moxibustion and acupuncture for the treatment of Crohn's disease显示文摘AIM: To evaluate the clinical efficacy and safety of acupuncture and moxibustion for the treatment of active Crohn's disease(CD).METHODS: Ninety-two patients were equally and randomly divided into the treatment group and received herb-partitioned moxibustion combined with acupuncture, and the control group received wheat bran-partitioned moxibustion combined with superficial acupuncture. The patients received three treatment sessions per week for 12 wk and were followed up for 24 wk. The main outcome was evaluated using the CD Activity Index(CDAI) score, and the secondary outcomes were evaluated using laboratory indicators such as hemoglobin(HGB), C-reactive protein(CRP), erythrocyte sedimentation rate, quality-of-life, endoscopic ratings, and intestinal histology scores.RESULTS: The CDAI scores of both the treatment and control groups were significantly reduced after treatment compared with those measured before treatment. However, the degree of improvement in the treatment group was significantly greater than that of the control group. The improvement in symptoms in patients of the treatment group was sustained at follow-up, whereas that of the control group was not. The overall efficacy of the treatment was significantly greater than that of the control. Both groups demonstrated significant improvements in quality-of-life ratings after treatment, but the improvement was significantly greater in the treatment group than in the control group. In addition, the patients in the treatment group showed significantly increased HGB and significantly decreasedCRP levels and histopathological scores at the end of treatment, whereas the control group did not exhibit significant changes.CONCLUSION: Moxibustion with acupuncture provided significant therapeutic benefits in patients with active CD beyond the placebo effect and is therefore an effective and safe treatment for active CD. | Chun-Hui Bao Ji-Meng Zhao Hui-Rong Liu Yuan Lu Yi-Fang Zhu Yin Shi Zhi-Jun Weng Hui Feng Xin Guan Jing Li Wei-Feng Chen Lu-Yi Wu Xiao-Ming Jin Chuan-Zi Dou Huan-Gan Wu | 2014 | World Journal of Gastroenterology2014，20，31： | 19 |
| 17 | Protein kinase A-mediated cardioprotection of Tongxinluo relates to the inhibition of myocardial inflammation, apoptosis, and edema in reperfused swine hearts显示文摘 | LI Xiang-dong YANG Yue-jin CHENG Yu-tong DOU Ke-fei TIAN Yi MENG Xian-min | 2013 | Chinese Medical Journal2013，，8： | 18 |
| 18 | Fine Mapping and Cloning of the Grain Number Per-Panicle Gene (Gnp4) on Chromosome 4 in Rice (Oryza sativa L.)显示文摘Grain number per-panicle is one of the most important components for rice yield. Spikelets on the primary and secondary branches determine the grain number per-panicle in rice. In this study, we identified a natural mutant, gnp4, lack of lateral spikelet on the secondary branches in the field condition. In addition, the Gnp4 and Lax1-1 double mutant showed dramatically reduced secondary branches and spikelets in panicle at reproductive stage, and tillers at vegetative stage. By map-based cloning approach, and using four F2 segregating populations, the Gnp4 gene was finally mapped to a 10.7-kb region on the long arm of chromosome 4 in rice. In this region, only one gene was predicted, and genomic DNA sequencing of the 10.7-kb region showed no nucleotide differences between the mutant and wild type. Interestingly, we found that the methylation level of several cytosines in the promoter CpG islands region of the predicted gene in gnp4 were different from the wild type. Thus, we propose that the DNA methylation changes at these sites may induce to decrease expression level of Gnp4, consequently, resulting in phenotypic variation. | ZHANG Zhan-ying LI Jin-jie YAO Guo-xin ZHANG Hong-liang DOU Hui-jing SHI Hong-li SUN Xing-ming LI Zi-chao | 2011 | Agricultural Sciences in China2011，10，12： | 17 |
| 19 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 20 | Study on fault induced rock bursts显示文摘In order to study the rules of rock bursts caused by faults by means of mechanical analysis of a roof rock-mass balanced structure and numerical simulation about fault slip destabilization, the effect of coal mining operation on fault plane stresses and slip displacement were studied. The results indicate that the slip displacement sharply increases due to the decrease of normal stress and the increase of shear stress at the fault plane when the working face advances from the footwall to the fault itself, which may induce a fault rock burst. However, this slip displacement will be very small due to the increase of normal stress and the decrease of shear stress when the working face advances from the hanging wall to the fault itself, which results in a very small risk of a fault rock burst. | LI Zhi-hua DOU Lin-ming LU Cai-ping MU Zong-long CAO An-ye | 2008 | Journal of China University of Mining and Technology2008，18，3： | 17 |
您所在的机构暂未开通此部分的功能，请联系管理员