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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Evaluation of contact resistance for isotropic electrically conductive adhesives 显示文摘 | Gaynes M A Lewis R H | 1995 | IEEE Trans Compon Packg Manuf Tech Part B1995，18，3： | 2 |
| 4 | Super-resolution land cover pattern prediction using a Hopfield neural network 显示文摘 | TATEM A J LEWIS H G ATKINSON P M NIXON M S | 2002 | Remote Sensing of Environment2002，，： | 1 |
| 5 | Improved Surface Properties of Polymer Materisls by Multiple Lon Beam Treatment显示文摘 | Lee E H Lewis M B Blau P J | 1991 | Mater Res1991，6，3： | 1 |
| 6 | Identification of urocortin III,an additional member of the corticotrophin-releasing factor (CRF) family with high affinity for the CRF2 receptor显示文摘 | Lewis K Li C Perrin M H | 2001 | Proc Natl Acad Sci USA2001，98，13： | 1 |
| 7 | Epidemiology of insomnia: a longitudinal study in a UK population 显示文摘 | Morphy H Dunn KM Lewis M | 2007 | Sleep2007，30，3： | 1 |
| 8 | Variation in trophie shift for stable isotope ratios of carbon, nitrogen, and sulfur显示文摘 | MCCUTCHAN JR J H LEWIS JR W M KENDALL C | 2003 | Oikos2003，102，2： | 1 |
| 9 | Web space reconstruction with a M-V flap显示文摘 | LEWIS R C NORDYKE M D DUNCAN K H | 1988 | J Hand Surg Am1988，13，1： | 1 |
| 10 | Multiple-class land-cover mapping at the sub-pixel scale using a Hopfield neural network 显示文摘 | Tatem A J Lewis H G Atkinson P M | 2001 | International Journal of Applied Earth Observation and Geoinformation2001，3，2： | 1 |
| 11 | Rationale for control of anthropogenic nitrogen and phosphorus to reduce eutrophication of inland waters 显示文摘 | LEWIS J W M WURTSBAUGH W A PAERL H W | 2011 | Science and Technology2011，45，10： | 1 |
| 12 | The Dully blood group system in Caucasians: evidence for a new allele 显示文摘 | Chown B Lewis M Kaita H | 1965 | Am J Hum Genet1965，17，1： | 1 |
| 13 | Do OA patients gain additlottal benefit from care from a clinical nurse specialist? -a randomized ellnical trial显示文摘 | Hill J Lewis M Bird H | 2009 | Rheu- matology2009，48，： | 1 |
| 14 | Prediction of mammalian microRNA targets显示文摘 | Lewis B P Shih I H Jones-Rhoades M W | 2003 | Cell2003，115，7： | 1 |
| 15 | Increasing the spatial resolution of agricultural land cover maps using a Hopfield neural network 显示文摘 | Tatem A J Lewis H G Atkinson P M | 2003 | International Journal of Geographical Information Science2003，17，7： | 1 |
| 16 | High Precision Formation Control of Mobile Robots Using Virtual Structures显示文摘 | Lewis M Tan K H | 1997 | Autonomous Ro- bots1997，4，4： | 1 |
| 17 | A generalized confusion matrix for assessing area estimates from remotely sensed data 显示文摘 | Lewis H G Brown M | 2001 | International Journal of Remote Sensing2001，22，16： | 1 |
| 18 | Multiple-class landcover mapping at the sub-pixel scale using a Hopfield neural network 显示文摘 | Tatem A J Lewis H G Atkinson P M | 2001 | International Journal of Applied Earth Observation and Geoinformation2001，3，2： | 1 |
| 19 | Prediction of mammalian microRNA targets显示文摘 | Lewis B P Shih I H Jones-Rhoades M W | 2003 | Cell2003，115，： | 1 |
| 20 | Multipleclass land cover mapping at the sub-pixel scale using aHopfield neural network显示文摘 | Tatem A J Lewis H G Atkinson P M | 2001 | International Journal ofApplied Earth Observation and Geoinformation2001，3，2： | 1 |
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