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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Water use efficiency and biomass partitioning of three different miseanthus genotypes with limited and unlimited water supply 显示文摘 | Clifton-brown J C Lewandowski I | 2000 | Annals of Botany2000，86，1： | 1 |
| 3 | Three-dimensional biofilm structure quantification显示文摘 | BEYENAL H DONOVAN C LEWANDOWSKI Z | 2004 | J Microbiol Methods2004，59，3： | 1 |
| 4 | Myths regarding NINDS rtPA Stroke Trial: setting the record straight显示文摘 | Haley EC Lewandowski C Tilley BC | 1997 | Ann Emerg Med1997，30，7： | 1 |
| 5 | Treatment of acute ischemic stroke显示文摘 | Lewandowski C Barsan W | 2001 | Annals of Emergency Medicine2001，37，2： | 1 |
| 6 | Miscanthus:european experience with a novel energy crop显示文摘 | LEWANDOWSKI I CLIFTON-BROWN J C SCURLOCK J M O | 2000 | Biomass &Biocnergy2000，19，4： | 1 |
| 7 | Increased circulating levels of matrix metaUoproteinase-2 and -9 in women with the polycystic ovary syndrome显示文摘 | Lewandowski K C Komorowski J O'Callaghan C J | 2006 | J Clin Endocrinol Metab2006，91，3： | 1 |
| 8 | Miscanthus: European experience with a novel energy crop显示文摘 | Lewandowski I Clifton Brown J C Scurlock J M O | 2000 | Biomass and Bioenergy2000，19，4： | 1 |
| 9 | Biomass production potentials in Central and Eastern Europe under different scenarios显示文摘 | Van DAM J FAAIJ A P C LEWANDOWSKI L FISCHER G | 2007 | Biomass Bioenergy2007，31，6： | 1 |
| 10 | Galileo/SAR: performance aspects and new service capabilities显示文摘 | Lewandowski A Niehoefer B and Wietfeld C | 2010 | International Journal of Satellite Communications and Networking2010，28，6： | 1 |
| 11 | Genotypic variation in cold tolerance influences the yield of Miscanthus 显示文摘 | Farrell A D Clifton-Brown J C Lewandowski I | 2006 | Annals of applied biology2006，149，3： | 1 |
| 12 | European experience with a novel energy crop显示文摘 | Lewandowski I Clifton-Brown J C Scurlock J M O | 2000 | Biomass and Bioenergy2000，19，4： | 1 |
| 13 | A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells显示文摘 | WILLIAMS C EDVARDSSON K LEWANDOWSKI S A | 2008 | Oncogene2008，27，7： | 1 |
| 14 | Gene expression during abscission of Valencia citrus fruit and leaves显示文摘 | BURNS J K NAIRN C J LEWANDOWSKI D J | 1995 | Proc Fla State Hort Soc1995，108，1： | 1 |
| 15 | Treatment of acute ischemicstroke显示文摘 | Lewandowski C Barsan W | 2001 | Ann Emerg Med2001，37，7： | 1 |
| 16 | The modeled productivity of Miscanthus× giganteus (Greef et Deu) in Ireland显示文摘 | CLIFTON BROWN J C NEILSON B LEWANDOWSKI I | 2000 | Industrial Crops and Products2000，12，： | 1 |
| 17 | Design and development of a flexible strain sensor for textile structures based on a conduc- tive polymer composite显示文摘 | COCHRANE C KONCAR V LEWANDOWSKI M | 2007 | Sensors2007，7，4： | 1 |
| 18 | Ultrahigh-temperature Nb- silicide- based composites 显示文摘 | Bewlay B P Jackson M R Zhao J C Subramanian P R Mendiratta M G Lewandowski J J | 2003 | Mrs Bulletin2003，28，9： | 1 |
| 19 | Myths regarding the NINDS rt-PA Stroke Trial:setting the record straight显示文摘 | Haley EC Lewandowski C Tillcy BC | 1997 | Ann EmergMed1997，30，： | 1 |
| 20 | Galileo/ SAR:Performance Aspects and New Service Capabilities 显示文摘 | LEWANDOWSKI A NIEHOEFER B WIETFELD C | 2010 | International Journal of Satellite Communications and Networking2010，28，6： | 1 |
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