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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Desmoid tumor: a disease opportune for molecular insights 显示文摘 | Kotiligam D Lazar A J Pollock R E Lev D | 2008 | Histol Histopathol2008，23，： | 1 |
| 3 | Generalized Synchronization of Chaos in Directionally Coupled Chaotic System显示文摘 | Nikolai F R Mikhall M S Lev S T | 1995 | Phys Rev E1995，51，： | 1 |
| 4 | Sonophotocatalytic destruction of organic contaminants in aqueous systems on TiO2 powders 显示文摘 | Lev D Euireddy P R Paul F | 2001 | Appl Cata B : Environ2001，32，： | 1 |
| 5 | JAK2 V617F mutation in platelets from essential thrombocy them ia patients:corretation with clinical features and analysis of STA33 phosphorylation status 显示文摘 | HELLER P G LEV P R SALINI J P | 2006 | Eur J Haematol2006，77，3： | 1 |
| 6 | Generation of oscillation by the p53-Mdm2 feedback loop: a theoretical and experimental study 显示文摘 | LEV B R MAYA R SEGEL L A | 2000 | Proceedings of the National Academy of Sciences USA2000，97，11： | 1 |
| 7 | Colon polyp registries and colorectal cancer control显示文摘 | Lev R Healey J | 1999 | Cancer Detect Prey1999，23，： | 1 |
| 8 | TiO2 - loaded zeolites and mesoporous materials in the sonophotocatalytic decomposition of aqueous organic pollutants:the role of the support显示文摘 | Euireddy P R Lev D Panagiotis S | 2003 | Appl Carol B : Environ2003，42，： | 1 |
| 9 | Aggressive periodontitis among young Israeli army personnel显示文摘 | Levin L Baev V Lev R | 2006 | J Periodontol2006，77，8： | 1 |
| 10 | Effect of previous treatment with statins on outcome of patients with ST-segment elevation myoeardial infarction treated with primary pereutaneous coronary intervention 显示文摘 | Lev EI Komowski R Vaknin-Assa H | 2009 | Am J Cardio12009，103，2： | 1 |
| 11 | How in Situ Expansion Affects Casing and Tubing Properties显示文摘 | Mack R D Lev R | 1999 | World Oil1999，220，7： | 1 |
| 12 | Prophylactic lidocaine use preintubation:a review显示文摘 | Lev R Rosen P | 1994 | J Emerg Med1994，，： | 1 |
| 13 | Encapsulation of luminous recombinant E-coli in sol-gel silicate films显示文摘 | Premkumar J R Lev O Rosen R | 2001 | Advanced Materials2001，13，： | 1 |
| 14 | Man- agerial Ability and Earnings Quality显示文摘 | DEMERJIAN P R LEV B LEWIS M F | 2013 | The Account- ing Review2013，88，2： | 1 |
| 15 | Fundamental Information Analysis 显示文摘 | Lev B Thiagarajan S R | 1993 | Journal of Accounting Research1993，31，： | 1 |
| 16 | Effect of previous treat- ment with statins on outcome of patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention显示文摘 | Lev EI Komowski R Vaknin-Assa H | 2009 | Am J Cardiol2009，103，2： | 1 |
| 17 | To warn or not to wam: Management disclosures in the face of an earnings sur- prise显示文摘 | Kasznik R Lev B | 1995 | Accounting Review1995，70，1： | 1 |
| 18 | Sonophotocatalytic destruction of organic contaminants in aqueous systems on TiO2 powders显示文摘 | Lev D Ettireddy P R France P | 2001 | Applied Catayst B:Environmental2001，，32： | 1 |
| 19 | Fundamental Information Analy- sis 显示文摘 | Lev B Thiagarajan S R | 1993 | Journal of Accounting Research1993，，31： | 1 |
| 20 | Hydronephrosis associ- ated with colorectal carcinoma: treatment and outcome 显示文摘 | Lev - Chelouche D Keidar A Rub R | 2001 | Eur J Surg Onco12001，27，： | 1 |
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