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| 1 | Sci Rep:科学家阐明线粒体的程序性细胞死亡过程显示文摘日前。发表在Scientific Reports杂志上的一篇研究报告中,来自加利福尼亚大学等机构的研究人员通过利用一种由石墨烯组成的新型传感器深入解析了线粒体的程序性细胞死亡过程,该研究或为驱动癌细胞自我毁灭提供了新的线索。研究者通过研究开发了一种监测线粒体改变的电子学方法,该方法能够指示出细胞进行自我毁灭的开始阶段,我们机体每个细胞中都有数百个、甚至数千个线粒体。每个线粒体都有着内膜和外膜结构;作为细胞的能量工厂,线粒体会对细胞中的碳水化合物和脂肪进行代谢产能以便细胞利用并且储存。但同时线粒体还有第二个角色,那就是调节细胞的生死通路。 | Ted D. Pham Phi Q. Pham Jinfeng Li Anthony G. Letai Douglas C. Wallace Peter J. Burke | 2016 | 现代生物医学进展2016，16，35： | 4 |
| 2 | Distinct BH3domains either sensitize or activate mitochondrial apoptosis,serving as prototype cancer therapeutics显示文摘 | Letai A Bassik M C Walensky L D | 2002 | Cancer Cell2002，2，3： | 1 |
| 3 | Control of mitochondrial apoptosis by the Bcl-2 family显示文摘 | Brunelle JK Letai A | 2009 | J Cell Sci2009，122，4： | 1 |
| 4 | Control of mitochondriaI apoptosis by the Bcl - 2 family 显示文摘 | Brunelle J K Letai A | 2009 | CelI Sci2009，122，4： | 1 |
| 5 | Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel induced apoptosis in breast cancer cells显示文摘 | Kutuk O Letai A | | 0，，10： | 1 |
| 6 | Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 显示文摘 | Opferman JT Letai A Beard C | 2003 | Nature2003，426，6967： | 1 |
| 7 | Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells显示文摘 | Kutuk O Letai A | 2010 | Cell Death Differ2010，1，3： | 1 |
| 8 | Control of mitochondrial apoptosis by the Bel-2 family 显示文摘 | Brunelle JK Letai A | 2009 | J Cell Sci2009，122，4： | 1 |
| 9 | Distinct BH3 domain either sensitize or activate mitochondrial apoptosis,serving as prototype cancer therapeutics显示文摘 | Letai A Bassik MC Walensky LD | 2002 | Cancer Cell2002，2，3： | 1 |
| 10 | Cancer,coagulation,and anticoagulation显示文摘 | Letai A Kuter DJ | 1999 | Oncolo-gist1999，4，6： | 1 |
| 11 | Pharmacological manipulation of bcl-2 family members to control cell death显示文摘 | Letai A | 2005 | J Clin Invest2005，115，： | 1 |
| 12 | 显示文摘 | Brunelle J K Letai A | 2009 | J Cell Sci2009，122，4： | 1 |
| 13 | Control of mitochondrial apoptosis by the Bcl-2 family显示文摘 | Brunelle JK Letai A | 2009 | J Cell Sci2009，122，4： | 1 |
| 14 | Control of mitoehondrial apoptosis by the B,:l-2 family 显示文摘 | Brunelle JK Letai A | 2009 | J Cell Sei2009，122，4： | 1 |
| 15 | Distinct BH3 domains ei ther sensilize or aclivate mitochondria apoplosis, serving as prototype cancer therapeutics显示文摘 | Letai A Bassik M C Walensky L D | 2002 | Cancer Cell2002，2，3： | 1 |
| 16 | Control of mitochondrial apoptosis bythe Bcl-2 family显示文摘 | Brunelle JK Letai A | 2009 | J Cell Sci2009，122，4： | 1 |
| 17 | Distinct BH3 domains either sensitize or activate mitoehondrial apoptosis, serving as prototype cancer therapeutics 显示文摘 | Letai A Bassik M C Walensky L D | 2002 | Cancer Cell2002，2，3： | 1 |
| 18 | Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics 显示文摘 | Letai A Bassik M C Walensky L D | 2002 | Cancer Cell2002，2，3： | 1 |
| 19 | Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxd resistance and can be reversed by ABT-737显示文摘 | Kutuk O Letai A | 2008 | Cancer Res2008，68，19： | 1 |
| 20 | Mimicking the BH3 domain to kill cancer cells 显示文摘 | Ni Chonghaile T Letai A | 2008 | Oncogene2008，271，： | 1 |
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