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| 1 | Resuscitation after prolonged ventricular fibrillation with use of monophasic and biphasic waveform pulses for external defibrillation显示文摘 | Leng CT Paradis NA Calkins H et td | 2000 | Circulation2000，101，： | 1 |
| 2 | Resuscitation after prolonged ventricular fibrillation with use of monophasic and biphasic waveform pulses for external defibrillation显示文摘 | Leng CT Paradis NA Calkins H | | 0，，25： | 1 |
| 3 | Humoral mechanism in pathogenesis of portal hypertension显示文摘 | Hung CT Du RY Leng XS | 1982 | Chin Med Egnl1982，95，6： | 1 |
| 4 | CIM4 is the signaling component ff the macrophage migration inhibitory tactor-CD74 reeeptor complex 显示文摘 | Shi X Leng L Warren K ct al | 2006 | hnmunity2006，25，4： | 1 |
| 5 | The 'Humoral Mechanism':A factor in the pathogenesis of portal hypertension显示文摘 | Huang CT Du RY Leng XS | 1982 | Zhonghua Waike Zazhi1982，20，9： | 1 |
| 6 | Humoral mechanism in pathogensis of portal hypertension显示文摘 | Huang CT Du RY Leng XS | 1982 | Chin Med J1982，95，： | 1 |
| 7 | Effect of cimetidine on wedged hepatic venous pressure in cirrhotic patients 显示文摘 | Leng XS Huang CT Wang XG | 1991 | Chin Med J1991，104，： | 1 |
| 8 | Resuscitation after pro- longed ventricular ibriUation with use of monophasic and biphasic waveform pulses for external defibrillation显示文摘 | Leng CT Paradis NA Calkins H | 2000 | Circulation2000，101，： | 1 |
| 9 | Multipleroles of HDAC inhibition in neurodegenerative conditions显示文摘 | CKuang DM Leng Y Marinova Z* Kim HJ Chiu CT | 2009 | Trends Neurosci2009，32，11： | 1 |
| 10 | Humoral mechanisms in the pathogensis of portal hypertension显示文摘 | HUANG CT DU RY LENG XS | 1982 | Chinese M J1982，95，： | 1 |
| 11 | Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease显示文摘Objectives The predisposition of intracranial atherosclerotic disease(ICAD)to East Asians over Caucasians infers a genetic basis which,however,remains largely unknown.Higher prevalence of vascular risk factors(VRFs)in Chinese over Caucasian patients who had a stroke,and shared risk factors of ICAD with other stroke subtypes indicate genes related to VRFs and/or other stroke subtypes may also contribute to ICAD.Methods Unrelated symptomatic patients with ICAD were recruited for genome sequencing(GS,60-fold).Rare and potentially deleterious single-nucleotide variants(SNVs)and small insertions/deletions(InDels)were detected in genome-wide and correlated to genes related to VRFs and/or other stroke subtypes.Rare aneuploidies,copy number variants(CNVs)and chromosomal structural rearrangements were also investigated.Lastly,candidate genes were used for pathway and gene ontology enrichment analysis.Results Among 92 patients(mean age at stroke onset 61.0±9.3 years),GS identified likely ICAD-associated rare genomic variants in 54.3%(50/92)of patients.Forty-eight patients(52.2%,48/92)had 59 rare SNVs/InDels reported or predicted to be deleterious in genes related to VRFs and/or other stroke subtypes.None of the 59 rare variants were identified in local subjects without ICAD(n=126).31 SNVs/InDels were related to conventional VRFs,and 28 were discovered in genes related to other stroke subtypes.Our study also showed that rare CNVs(n=7)and structural rearrangement(a balanced translocation)were potentially related to ICAD in 8.7%(8/92)of patients.Lastly,candidate genes were significantly enriched in pathways related to lipoprotein metabolism and cellular lipid catabolic process.Conclusions Our GS study suggests a role of rare genomic variants with various variant types contributing to the development of ICAD in Chinese patients. | Mengmeng Shi Xinyi Leng Ying Li Zihan Chen Ye Cao Tiffany Chung Bonaventure YM Ip Vincent HL Ip Yannie OY Soo Florence SY Fan Sze Ho Ma Karen Ma Anne Y Y Chan Lisa WC Au Howan Leung Alexander Y Lau Vincent CT Mok Kwong Wai Choy Zirui Dong Thomas W Leung | 2022 | Stroke & Vascular Neurology2022，7，3： | 0 |
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