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| 1 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 2 | Cardiovascular Autonomic Dysfunction and hemodynamic response to anesthetic Iinduction in patients with coronary artery disease and diabetes mellitus显示文摘 | Keyl C Lemberger P Palitzsch KD | 1999 | Anesth Analg1999，88，5： | 1 |
| 3 | A comparison of the use of transoesophageal Doppler and thermodilution techniques for cardiac output determination显示文摘 | Keyl G Roding P Lemberger P | 1996 | Eur J Anaesthesiol1996，13，2： | 1 |
| 4 | Mechanical fatigue as a mechanism of water tree propagation in TR-XLPE显示文摘 | Wang Z Marcolongo P Lemberg J A | 2012 | IEEE Transactions on Dielectrics and Electrical Insulation2012，19，1： | 1 |
| 5 | Nasal malignant meningioma 显示文摘 | Garcia-Purrinos FJ Cervilla AR Lemberg P | 2005 | Acta Otorrinolaringol Esp2005，56，8： | 1 |
| 6 | Water vapor permeation of selected cellulose ester films显示文摘 | Patel M Patel J M Lemberger A P | 1964 | J Pharm Sci1964，53，3： | 1 |
| 7 | Physiologic disposition of pergolide 显示文摘 | Lemberger L Dhahir P | 1981 | Clin Pharmacol Ther1981，30，： | 1 |
| 8 | A comparision of the use of transoesophageal dopper and thermodilution techniques for cardiac output detemination显示文摘 | Keyl C |lodig G Lemberger P et a/ | 1996 | Eur Anaesthesiol1996，13，2： | 1 |
| 9 | Water vapor permeation of selected cellulose ester films显示文摘 | Patel M Patel J M Lemberger A P | 1964 | J Pharm Sci1964，53，3： | 1 |
| 10 | Mechanical fatigue as a mechanism of water tree propagation in TR-XLPE显示文摘 | Wang Z Marcolongo P Lemberg J A | 2012 | IEEE Transac- tions on Dielectrics and Electrical Insulation2012，19，1： | 1 |
| 11 | Mechanical Fa-tigue as a Mechanism of Water Tree Propagation inTR-XLPE显示文摘 | Wang Z Marcolongo P Lemberg J | 2012 | Transactions on Dielectrics and Electrical In-sulation2012，19，1： | 1 |
| 12 | Geography Teaching and the New Technologies: Opportunities and Challenges 显示文摘 | LEMBERG D STOLTMAN J P | 2001 | Journal of Education2001，181，3： | 1 |
| 13 | Recruitment of RGS2 and RGS4 to the plasma membrane by G-proteins and receptors reflects functional interactions显示文摘 | Roy AA Lemberg KE Chidiac P | 2003 | Mol Pharmacol2003，64，3： | 1 |
| 14 | Nasalmalignant meningioma显示文摘 | García-Purriínos FJ Cervilla AR Lemberg P | 2005 | Acta Otorrinolaringol Esp2005，56，8： | 1 |
| 15 | Perioperative changes in cardiac autonomic control in patients recerving either general or local anesthesia for ophthalmic surgery 显示文摘 | Lemberger P Frey AW | 1996 | Anesth Analg1996，82，： | 1 |
| 16 | Physiologic disposition if pergolide 显示文摘 | Pubin A Lemberger L Dhahir P | 1981 | Chin Pharmaco Ther1981，30，： | 1 |
| 17 | MechanicalFatigue as a Mechanism of Water Tree Propagation inTR-XLPE显示文摘 | Wang Z Marcolongo P Lemberg J A | 2012 | IEEE Transactions on Dielectrics and ElectricalInsulation2012，19，1： | 1 |
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