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| 1 | AU-rich element-binding proteins in colorectal cancer显示文摘Trans-acting factors controlling mRNA fate are critical for the post-transcriptional regulation of inflammation-related genes, as well as for oncogene and tumor suppressor expression in human cancers. Among them, a group of RNA-binding proteins called 'Adenylate-Uridylate-rich elements binding proteins'(AUBPs)control mRNA stability or translation through their binding to AU-rich elements enriched in the 3'UTRs of inflammation-and cancer-associated mRNA transcripts. AUBPs play a central role in the recruitment of target mRNAs into small cytoplasmic foci called Processing-bodies and stress granules(also known as P-body/SG). Alterations in the expression and activities of AUBPs and Pbody/SG assembly have been observed to occur with colorectal cancer(CRC)progression, indicating the significant role AUBP-dependent post-transcriptional regulation plays in controlling gene expression during CRC tumorigenesis.Accordingly, these alterations contribute to the pathological expression of many early-response genes involved in prostaglandin biosynthesis and inflammation,along with key oncogenic pathways. In this review, we summarize the current role of these proteins in CRC development. CRC remains a major cause of cancer mortality worldwide and, therefore, targeting these AUBPs to restore efficient post-transcriptional regulation of gene expression may represent an appealing therapeutic strategy. | Noémie Legrand Dan A Dixon Cyril Sobolewski | 2019 | World Journal of Gastrointestinal Oncology2019，11，2： | 7 |
| 2 | Stress granules in colorectal cancer:Current knowledge and potential therapeutic applications显示文摘Stress granules(SGs)represent important non-membrane cytoplasmic compartments,involved in cellular adaptation to various stressful conditions(e.g.,hypoxia,nutrient deprivation,oxidative stress).These granules contain several scaffold proteins and RNA-binding proteins,which bind to mRNAs and keep them translationally silent while protecting them from harmful conditions.Although the role of SGs in cancer development is still poorly known and vary between cancer types,increasing evidence indicate that the expression and/or the activity of several key SGs components are deregulated in colorectal tumors but also in pre-neoplastic conditions(e.g.,inflammatory bowel disease),thus suggesting a potential role in the onset of colorectal cancer(CRC).It is therefore believed that SGs formation importantly contributes to various steps of colorectal tumorigenesis but also in chemoresistance.As CRC is the third most frequent cancer and one of the leading causes of cancer mortality worldwide,development of new therapeutic targets is needed to offset the development of chemoresistance and formation of metastasis.Abolishing SGs assembly may therefore represent an appealing therapeutic strategy to re-sensitize colon cancer cells to anti-cancer chemotherapies.In this review,we summarize the current knowledge on SGs in colorectal cancer and the potential therapeutic strategies that could be employed to target them. | Noémie Legrand Dan A Dixon Cyril Sobolewski | 2020 | World Journal of Gastroenterology2020，26，35： | 4 |
| 3 | Trasmission/Reflection method for low-loss Material complex permittivity Determination at Mivrowave显示文摘 | Boughriet A H Legrand C Chapoton A | 1997 | IEEE Trans on MTT1997，45，1： | 1 |
| 4 | Two-year clinical, an- giographic, and intravascular ultrasound follow-up of the XIENCE V everolimus-eluting stent in the treatment of patients with de novo native coronary artery lesions:the SPIRIT II trial 显示文摘 | Claessen B E Beijk M A Legrand V | 2009 | Circulation2009，2，4： | 1 |
| 5 | Cognitive apprenticeship显示文摘 | Farmer J A Buckmaster A LeGrand B | 1992 | New Directions for Adult and Continuing Education1992，，： | 1 |
| 6 | In vitro antibacterial activity of doripenem against clinical isolates from French teaching hospitals : proposition of zone diameterbreakpoints显示文摘 | LASCOLS C LEGRAND P MERENS A | 2011 | Eur J Clin Microbiol Infect Dis2011，30，4： | 1 |
| 7 | Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells显示文摘 | LEGRAND D VIGIE K SAID E A | 2004 | Eur J Biochem2004，271，： | 1 |
| 8 | A Study of the Feasibility of a Monoblock Racing Motorcycle Rim显示文摘 | Legrand M Ngoc Q A P | 2001 | Composites Science and Technology2001，61，： | 1 |
| 9 | A study of the feasibility of a monoblock racing motorcycle rim显示文摘 | LEGRAND M NGOC Q A P | 2001 | Composites Science and Technology2001，61，： | 1 |
| 10 | Interleukin-1,tumor necrosis factor alpha,and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci显示文摘 | LeGrand A Fermor B Fink C | 2001 | Arthritis Rheum2001，44，9： | 1 |
| 11 | Platelet Dysfunction Associated With Insulin Therapy in Patients With Type 2 Diabetes: Please Do Not Throw the Baby Out With the Bathwater! 显示文摘 | Scheen A J Legrand D | 2007 | J Am Coil Cardiol2007，49，5： | 1 |
| 12 | Scheduling divisible loads on star and tree networks:results and open problems显示文摘 | BEAUMONT O CASANOVA H LEGRAND A | 2005 | IEEE Trans on Parallel and Distributed Systems2005，16，3： | 1 |
| 13 | Respiratory effects of the external and internal intercostal muscles in hu- man显示文摘 | Wilson TA Legrand A Gcbenois PA | 2001 | J Physiol2001，530，2： | 1 |
| 14 | Melt growth and shrinkage at the exit of the die in the extrusion-cooking process 显示文摘 | Arhaliass A Bouvier J M Legrand J | 2003 | Journal of Food Engineering2003，60，2： | 1 |
| 15 | Interleukin- 1 , tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prosta?glandin E2 production in ex plants of human osteo?arthritic knee menisci显示文摘 | Legrand A Fermor B Fink C | 2001 | Arthritis Rheum2001，44，9： | 1 |
| 16 | Interleukin-l, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisei显示文摘 | LeGrand A Fermor B Fink C | 2001 | Arthritis Rheum2001，44，9： | 1 |
| 17 | Respiratory effects of the external and internal intercostals muscles in humans显示文摘 | Wilson TA Legrand A Gevenois PA | 2001 | J Physiol2001，530，2： | 1 |
| 18 | Scheduling divisible loads on star and tree networks:Results and open problems显示文摘 | Beaumont O Casanova H Legrand A | 2005 | IEEE Trans on Parallel and Distributed Systems2005，16，3： | 1 |
| 19 | Association of platelet thrombospondin-1 with the actin cytoskeleton显示文摘 | Saumet A Jesus N Legrand C | 2002 | Biochem J2002，363，3： | 1 |
| 20 | High efficacy and safety profile of fractionated doses of Mylotarg as induction therapy in patients with relapsed acute myeloblastic leukemia:a prospective study of the alfa group显示文摘 | Taksin A L Legrand O Raffoux E | 2007 | Leukemia2007，21，1： | 1 |
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