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| 1 | Hypothalamic-pituitary-adrenal axis function during perinatal depression显示文摘Abnormal function of the hypothalamic–pituitary–adrenal(HPA) axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol proinflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 11β-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby. | Phillipe Leff Gelman Mónica Flores-Ramos Margarita López-Martínez Carlos Cruz Fuentes Juan Pablo Reyes Grajeda | 2015 | Neuroscience Bulletin2015，31，3： | 6 |
| 2 | Spatial distribution,seston removal,and potential competitive interactions of the bivalves Corbicula fluminea and Elliptio complanata,in a coastal plain stream显示文摘 | Burch J L McArthur J V | 1990 | Freshwater Biology1990，24，2： | 1 |
| 3 | Seasonal changes in planktonic bacterial assemblages of two Ohio Streams 显示文摘 | LEFF L G LEFF A A LEMKE M J | 1998 | Freshwater Biol1998，39，1： | 1 |
| 4 | Drug therapy of the idiopathtic inflammatory myositis:predictors of response to prednisone,azathiopine,and methotrexate and a comparison of their efficacy显示文摘 | Joffe M M Love L A Leff R L | 1993 | Am J Med1993，1994，： | 1 |
| 5 | Hospital at home: Feasibility and outcomes of a program to provide hospi- tal-level care at home for acutely ill older patients显示文摘 | Leff B Burton L Mader S L | 2005 | Ann Intern Med2005，143，11： | 1 |
| 6 | Drug therapy of the idiopathic inflammatory myopathies:predictors of response to prednisone,azathioprine,and methotrexate and a comparison of their efficacy显示文摘 | Joffe M M Love L A Leff R L | 1993 | Am J Med1993，94，4： | 1 |
| 7 | Montelukast reduces airway eo-sinophilic inflammation in asthma:a randomized,controlled trial显示文摘 | Pizziehini EJA Leff TF Reiss L | 1999 | Eur Respir J1999，12，1： | 1 |
| 8 | The effect of guided care teams on the use of health services: results from a cluster - randomized controlled trial 显示文摘 | Boult C Reider L Leff B | 2011 | Arch Intern Med2011，171，5： | 1 |
| 9 | Use of green fluorescent protein to monitor survival of genetically engineered bacteria in aquatic environments 显示文摘 | Leff L G Leff A A | 1996 | Appl Environ Microbiol1996，62，9： | 1 |
| 10 | Montelukast reduces airway eosinop- hilic inflammaiLion in asthma:a randomized, controlled trial 显示文摘 | Pizichni Leff TF Reiss L | 2009 | Eur Respir J2009，20，12： | 1 |
| 11 | Comparison of methods of DNA extraction from stream sediment显示文摘 | Leff L G Dana J R McArthur J V Shimkets L J 1995 | 1995 | A pplied and Environmental Microbiology1995，61，： | 1 |
| 12 | Comparison of methods of DNA extraction from stream sediments显示文摘 | LEFF L G DANA J R McArthur J V | 1995 | Applied and Environmental Microbiology1995，61，3： | 1 |
| 13 | Montelukast reduces airway eosinophilic inflammation in asthma:a randomized,controlled trial显示文摘 | Pizziehini EJA Leff TF Reiss L et a1 | 1999 | Eur Respir J1999，12，1： | 1 |
| 14 | Comparison of methods of DNA extraction from stream sediments显示文摘 | LEFF L G DANA J R MCARTHUR J V | 1995 | Applied and environmental microbiology1995，61，3： | 1 |
| 15 | Montelukast reduces air- way eosinophilic inflammation in asthma: a randomized, controlled trial显示文摘 | Pizichni Leff TF Reiss L | 2009 | European Respiratory Journal2009，13，1： | 1 |
| 16 | Replication algorithms in a remote caching architecture显示文摘 | Leff A Wolf J L Yu P S | 1993 | IEEE Transactions on Parallel and Distributed Systems1993，4，11： | 1 |
| 17 | Diffuse optical imaging of the healthy and diseased breast:A system review显示文摘 | Leff D R Warren O J Enfield L C | 2008 | Breast Cancer Res Treat2008，108，1： | 1 |
| 18 | Montelukast reduces airway eosinophilic inflammation in asthma:a randomized,controlled trial显示文摘 | Pizichni Leff TF Reiss L | | 0，，12： | 1 |
| 19 | Diffuse optical imaging of the healthy and diseased breast: a system review显示文摘 | LEFF D R WARREN O J ENFIELD L C | 2008 | Breast Cancer Res Treat2008，108，1： | 1 |
| 20 | Use of green fluorescent protein to monitor survival of genetically engineered bacteria in aquatic environments 显示文摘 | Leff A A | 1996 | Appl Environ Microbiol1996，62，9： | 1 |
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