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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | The phylogeny and systematics of the endemic Ethiopian Lophuromys flavopunctatus species complex based upon random amplified polymorphic DNA (RAPD) analysis显示文摘 | Lavrenchenko L A Potapov S G Lebedev V S | 2001 | Bioch Syst Ecol2001，29，11： | 1 |
| 3 | Brain - machine interface : pase,present and future 显示文摘 | Lebedev M A Nicolelis M A L | 2006 | Trends in Neurosciences2006，29，9： | 1 |
| 4 | The effect of heavy metals and lume on urease activity podzalic soil显示文摘 | Lebedeval L A Lebedev S N Edemskaya N L | 1995 | Moscow University Soil Science Bul- letin1995，50，2： | 1 |
| 5 | Self-organization of sulfonated polystyrene ionomers in low-polarity solvents显示文摘 | LEBEDEV V T MEL' NIKOV A B VINOGRADOVA L V | 2010 | Polymer Science Series C2010，52，1： | 1 |
| 6 | Antioxidant properties, autooxidation, and mutagerdc activity of echinochrome: a compared with its etherified derivative显示文摘 | LEBEDEV A V LEVITSKAYA E L TIKHONOVA E V | 2001 | Biochemistry (Moscow)2001，66，8： | 1 |
| 7 | Model Parameters of the Nonlinear Stiffness of the Vibra- tor-ground Contact Determined by Inversion of Vi- brator Accelerometer Data显示文摘 | Lebedev A V Beresnev I A Vermeer P L | 2006 | Geophysics2006，71，3： | 1 |
| 8 | Nonlinear distortion of signals radiated by vibroseis sources显示文摘 | Lebedev A V Beresnev L A | 2004 | Geophysics2004，69，4： | 1 |
| 9 | Brain-machine interfaces: past, present and future 显示文摘 | Lebedev M A Nicolelis M A L | 2006 | TRENDS in Neurosciences2006，29，9： | 1 |
| 10 | Nonlinear distortion of signals radiated by vibroseis sources显示文摘 | Lebedev A V Beresnev L A | 2004 | Geophysics2004，69，4： | 1 |
| 11 | Model parameters of the nonlinear stiffness of the vibratorground contact determined by inversion of vibrator accelerometer data显示文摘 | Lebedev A V Beresnev L A Vermeer P L | 2006 | Geophysics2006，71，3： | 1 |
| 12 | Brain-machine interfaces: Past, present and future显示文摘 | LEBEDEV M A NICOLELIS M A L | 2006 | Trends in Neurosciences2006，29，： | 1 |
| 13 | Nonlinear distortion of signals radiated by vibroseis source显示文摘 | Lebedev A V Beresnev L A | 2004 | Geophysics2004，69，4： | 1 |
| 14 | Model parameters of nonlinear stiffness of the vibrator-ground contact determined by inversion of vibrator aecelerometer data显示文摘 | Lebedev A V Beresnev L A Vermeer P L | 2006 | Geophysics2006，71，3： | 1 |
| 15 | Brain-machine interfaces:past,present and future显示文摘 | LEBEDEV M A NICOLELIS M A L | 2006 | Trends in Neurosciences2006，29，9： | 1 |
| 16 | Studies of the eracture process in composite structural elements based on strain measurements and the acoustic-emission technique显示文摘 | SER'EZNOV A N STEPANOVA L N LEBEDEV E Y | 2004 | Russian Journal of Nondestructive Testing2004，40，9： | 1 |
| 17 | Use of the a- coustic emission method in detecting the fracture process in spec- imens made of composite materials显示文摘 | Stepanova L N Lebedev E Y Kareev A E | 2004 | Russian Journal of Non- destructive Testing2004，40，7： | 1 |
| 18 | Electronic Structure of Carbon Nanotubes Modified by Alkali Metal Atoms显示文摘 | ZAPOROTSKOVA I V LEBEDEV N G CHERNOZATONSKI L A | 2004 | Phys Solid State2004，46，6： | 1 |
| 19 | The effect of heavy metals and lime on urease activity podzalic soil显示文摘 | Lebedeva L A Lebedev S N Edemskaya N L | 1995 | Moscow University Soil Science Bulletin1995，50，2： | 1 |
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