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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease显示文摘This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's disease.The vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of mood.It can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous system.Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment responses.These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease.More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit. | Júlio César Claudino dos Santos Leandro Freitas Oliveira Felipe Micelli Noleto Camilla Teixeira Pinheiro Gusmão Gerly Anne de Castro Brito Glauce Socorro de Barros Viana | 2023 | Neural Regeneration Research2023，18，12： | 2 |
| 3 | BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy显示文摘 | Cerchietti Leandro C Hatzi Katerina Caldas-Lopes Eloisi Yang Shao Ning Figueroa Maria E Morin Ryan D Hirst Martin Mendez Lourdes Shaknovich Rita Cole Philip A Bhalla Kapil Gascoyne Randy D Marra Marco Chiosis Gabriela Melnick Ari | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
| 4 | Comparison of a closed (Trach Care MAC) with an open endotracheal suction system in small premature infants显示文摘 | Leandro C Mercedes S Leona W | 2000 | J Pednatol2000，20，3： | 1 |
| 5 | Transfer of catechins and proanthocyanidins from solid parts of the grape cluster into wine显示文摘 | Pinto T Leandro M C | 1999 | Am J enol Vitic1999，50，： | 1 |
| 6 | A quantum particle swarm optimizer with chaotic mutation operato显示文摘 | Leandro D S C | 2008 | Chaos Solitons & Fractals2008，37，5： | 1 |
| 7 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Leandro Vinícius Alves Gurgel Júlio César Perin de Melo Jorge Carvalho de Lena Laurent Frédéric Gil | 2009 | Bioresource Technology2009，，13： | 1 |
| 8 | Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neuro- toxicity 显示文摘 | Leskela S Jara C Leandro - Garcfa LJ | 2011 | Pharmacogenomics J2011，11，： | 1 |
| 9 | Coffee oil as a potential feedstock for biodiesel production显示文摘 | Leandro S O Adriana S F Rodrigo R S C | 2008 | Bioresource Technology2008，，99： | 1 |
| 10 | Hexose and pentose transport in ascomycetous yeasts:an overview显示文摘 | Leandro M J Fonseca C Goncalves P | | 0，，04： | 1 |
| 11 | Phenothia zincs al- ter resistance of methicillin resistant strains of Staphylococcus au- reus(MRSA) to oxacillininvitro显示文摘 | Kristialasen MM Leandro C Ordway D | 2003 | Int J Anti mierob Agents2003，22，： | 1 |
| 12 | Learning and optimization using the clonal selection principle显示文摘 | LEANDRO N D C FERNANDO J V Z | 2002 | IEEE Trans on Evolutionary Computation2002，6，3： | 1 |
| 13 | Partial oxidation of methane over Ni-Co perovskite catalysts显示文摘 | Camila R B S Leandro D C Nielson F P R | 2011 | Catalysis Communi- cations2011，12，7： | 1 |
| 14 | B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients 显示文摘 | LEANDRO M J CAMBRIDGE G EDWARDS J C | 2005 | Rheumatology2005，44，12： | 1 |
| 15 | Determination of priority pesticides in baby foods by gas chromatography tandem quadrupole mass spectrometry显示文摘 | LEANDRO C C FUSSELL R J KEELY B J | 2005 | Journal of chromatography A2005，1085，2： | 1 |
| 16 | Use of chaotic sequences in a biologically inspired algorithm for engineering design optimization显示文摘 | VIVIANA C M | 2008 | Expert Systems with Applications2008，34，3： | 1 |
| 17 | Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation显示文摘 | Leandro S G Vicente B Angel C B | 2004 | J Pediatr2004，144，1： | 1 |
| 18 | Improved differential evolution algorithms for handing economic dispatch optimization with generator constraints显示文摘 | Leandro dos Santos Coelho Mariani V C | 2007 | Energy Conversion and Management2007，48，： | 1 |
| 19 | Ultra-performance liquid chromatography for the determination of pesticide residues in foods by tandem quadrupole mass spectrometry with polarity switching显示文摘 | LEANDRO C C HANCOCK P FUSSELL R J | 2007 | J Chromatogr: A2007，1144，2： | 1 |
| 20 | Effect of soil temperature and plant age at time of inoculation on progress of root rot and foliar symptoms of soybean sudden death syn- drome显示文摘 | GONGORA-CANUL C C LEANDRO L F S | 2011 | Plant Disease2011，95，4： | 1 |
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