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| 1 | Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol显示文摘AIM To analyse the risk factors and outcomes of delayed graft function(DGF) in patients receiving a steroid sparing protocol. METHODS Four hundred and twenty-seven recipients of deceased donor kidney transplants were studied of which 135(31.6%) experienced DGF. All patients received monoclonal antibody induction with a tacrolimus based, steroid sparing immunosuppression protocol.RESULTS Five year patient survival was 87.2% and 94.9% in the DGF and primary graft function(PGF) group respectively, P = 0.047. Allograft survival was 77.9% and 90.2% in the DGF and PGF group respectively, P < 0.001. Overall rejection free survival was no different between the DGF and PGF groups with a 1 and 5 year rejection free survival in the DGF group of 77.7% and 67.8% compared with 81.3% and 75.3% in the PGF group, P = 0.19. Patients with DGF who received IL2 receptor antibody induction were at significantly higher risk of rejection in the early post-transplant period than the group with DGF who received alemtuzumab induction. On multivariate analysis, risk factors for DGF were male recipients, recipients of black ethnicity, circulatory death donation, preformed DSA, increasing cold ischaemic time, older donor age and dialysis vintage.CONCLUSION Alemtuzumab induction may be of benefit in preventing early rejection episodes associated with DGF. Prospective trials are required to determine optimal immunotherapy protocols for patients at high risk of DGF. | Michelle Willicombe Anna Rizzello Dawn Goodall Vassilios Papalois Adam G Mc Lean David Taube | 2017 | World Journal of Transplantation2017，7，1： | 4 |
| 2 | Effect of femoral component designs on the contact and tracking characteristics of the unresurfaced patella in total knee arthroplasty显示文摘 | Tanzer M Mc Lean CA Laxer E | 2001 | Can J Surg2001，44，2： | 1 |
| 3 | Menin controls growth of pancreatic beta-cells in pregnant mice and promote gestational diabetes mellitus显示文摘 | Karnik S K Chen H Mc Lean G W | 2007 | Science2007，318，： | 1 |
| 4 | Neuropsychological outcome at one-month post injury显示文摘 | Dick S Lean MC Nayak T | 1986 | J Neurol Neurosurg Psychinalry1986，67，： | 1 |
| 5 | Photoelectron transfer from excited- state ruthenium( Ⅱ ) tris(bipyridyl)to methylviologen in an ionic liquid 显示文摘 | GORDON C M MC LEAN A J | 2000 | Chem Commun2000，，13： | 1 |
| 6 | The flipped classroom for medical students显示文摘 | Morgan H Mc Lean K Chapman C | 2015 | Clin Teach2015，12，3： | 1 |
| 7 | Tissue factor-dependent thrombin generation across pregnancy显示文摘 | Mc Lean KC Bernstein IM Brummel-Ziedins KE | 2012 | Am J Obstet Gynecol2012，207，2： | 1 |
| 8 | Biodiesel production from waste cooking oil Process and technologies assessment显示文摘 | Zhang Y Dube M A Mc Lean D D | 2003 | Bio resource Technology2003，，89： | 1 |
| 9 | MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling显示文摘 | Mc Donald RA Hata A Mac Lean MR | 2012 | Cardiovasc Res2012，93，： | 1 |
| 10 | Biological activity and enrichment of spermatogonial stem cells in vitamin A-deficient and hyperthermia-exposed testes from mice based on colonization following germ cell transplantation显示文摘 | Mc Lean D J Russell L D Griswold M D | 2002 | Biol Reprod2002，66，： | 1 |
| 11 | Epicardial adipose tissue and coronary artery plaque characteristics显示文摘 | Alexopoulos N Mc Lean DS Janik M | 2010 | Atherosclerosis2010，210，1： | 1 |
| 12 | Why does the law matter?Investor protection and its effects on investment,finance,and growth显示文摘 | Mc Lean R D Zhang T Y Zhao M X | 2012 | Journal of Finance2012，67，1： | 1 |
| 13 | Minimally invasive dentistry显示文摘 | Murdoch-Kinch CA Mc Lean ME | 2003 | Am Dent Assoc2003，134，1： | 1 |
| 14 | Callings and organizational behavior显示文摘 | Elangovan AR Pinder CC Mc Lean M | 2010 | J Vocat Behav2010，76，3： | 1 |
| 15 | Decomposition rate of organic substrates in relation to the species diversity of soil saprophytic fungi显示文摘 | Setala H Mc Lean M A | 2004 | Oecologia2004，139，： | 1 |
| 16 | Canadian Otolaryngology-Head and- Neck Surgery clerkship curricula: evolving toward tomorrow'sleamers 显示文摘 | Kelly K Fung K Mc Lean L | 2013 | J Otolaryngol Head Neck Surg2013，42，1： | 1 |
| 17 | Improved RNA extraction from woody plants for the detection of viral pathogens by reverse transcription-polymerase chain reaction显示文摘 | Donald J Mac Kenzie Morven A Mc Lean | 1997 | Plant Disease1997，81，2： | 1 |
| 18 | The effect of environment on plasma cortisol andβ-endorphin in the parturient pig and the involvement of endogenous opioids显示文摘 | JARVIS S LAWRENCE A B Mc LEAN K A | 1998 | Anim Reprod Sci1998，52，2： | 1 |
| 19 | Neuro-psychological outcome at one-month post injury 显示文摘 | Dick S Lean MC Nayak T | 1986 | Neurosurg Psychiatry1986，87，2： | 1 |
| 20 | Bench-to-bedside review:the value of cardiac biomarkers in the intensive care patient显示文摘 | Mc Lean AS Huang SJ Salter M | 2008 | Crit Care2008，12，3： | 1 |
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