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| 1 | The evolution and functional diversification of animal microRNA genes显示文摘microRNAs (miRNAs ) 是 22 核苷酸(nt ) 的一个丰富的班在更高真核细胞的染色体是弥漫的规章的 RNA。以便充分在染色体理解他们的突起,阐明是必要的能多样化 miRNA 活动的分子的机制。在这评论,我们描述一些允许新奇 miRNA 功能出现的许多策略,与 miRNA 基因怎么在动物演变的特别强调。这些机制在他们的顺序包括变化,处理,或表示模式;miRNA 的获得 * 功能或 antisense 处理;并且 de novo 基因出生。miRNAs 的设备和通用性位于下面多半演变并且变化他们怎么成为了更高的染色体的主导的成分。 | Na Liu Katsutomo Okamura David M Tyler Michael D Phillips Wei-Jen Chung Eric C Lai | 2008 | Cell Research2008，18，10： | 17 |
| 2 | Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist显示文摘AIM To investigate the impact of physical frailty on risk of hospitalisation in cirrhotic patients on the liver transplant waitlist.METHODS Cirrhotics listed for liver transplantation at a single centre underwent frailty assessments using the Fried Frailty Index, consisting of grip strength, gait speed, exhaustion, weight loss, and physical activity. Clinical and biochemical data including MELD score as collected at the time of assessment. The primary outcome was number of hospitalised days per year; secondary outcomes included incidence of infection. Univariable and multivariable analysis was performed using negative binomial regression to associate baseline parameters including frailty with clinical outcomes and estimated incidence rate ratios(IRR). RESULTS Of 587 cirrhotics, 64% were male, median age(interquartile range) was 60(53-64) years and MELD score was 15(12-18). Median Fried Frailty Index was 2(1-3); 31.6% were classified as frail(fried frailty ≥ 3). During 12 mo of follow-up, 43% required at least 1hospitalisation; 38% of which involved major infection.107/184(58%) frail and 142/399(36%) non-frail patients were hospitalised at least once(P < 0.001). In univariable analysis, Fried Frailty Index was associated with total hospitalisation days per year(IRR = 1.51,95%CI: 1.28-1.77; P ≤ 0.001), which remained significant on multivariable analysis after adjustment for MELD, albumin, and gender(IRR for frailty of 1.21,95%CI: 1.02-1.44; P = 0.03). Incidence of infection was not influenced by frailty.CONCLUSION In cirrhotics on the liver transplant waitlist, physical frailty is a significant predictor of hospitalisation and total hospitalised days per year, independent of liver disease severity. | Marie Sinclair Eduard Poltavskiy Jennifer L Dodge Jennifer C Lai | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 3 | 毛细管电泳法分析蜂花粉中黄酮类化合物(英文)显示文摘使用毛细管电泳法(CE)检测了健康食品中常见的六种黄酮类化合物:橙皮甙、海棠甙、异鼠李素、山奈酚、槲皮素、芦丁。研究了一系列的试验参数,如:pH、缓冲溶液浓度、分离电压以及UV检测器波长等,以确定出最佳条件。使用H3BO3-Na2B4O7缓冲液(pH9.2),各分析物可在8min内分出。相对标准偏差(RSD):8次进样的迁移时间为0.77%~0.93%;峰面积为3.8%~8.6%;各检测限(S/N=3)范围为0.34μg/ml~2.9μg/ml,回收率为80.4%~113.9%。方法简单、灵敏,重现性高,线性好,无须固相萃取前处理,用于蜂花粉分析结果准确。 | 卢挺 Edward P C Lai Jorn C C Yu 胡风祖 | 2006 | 食品科学2006，27，12： | 9 |
| 4 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 5 | Underutilization of palliative care services in the liver transplant population显示文摘AIM To evaluate use of palliative care services in patients with end-stage liver disease who do not have access to liver transplant.METHODS Evaluated were end-stage liver disease patients who were removed from the liver transplant wait-list or died prior to transplant at a single transplant center over a 2-year period. Those who were removed due to noncompliance or ultimately transplanted elsewhere were excluded from this study. Patient characteristics associated with palliative care consultation were assessed using logistic regression analysis.RESULTS Six hundred and eighty-three patients were listed for liver transplant in 2013-2014 with 107(16%) dying(n = 62) or removed for clinical decompensation prior to liver transplant(n = 45): Median age was 58 years, and the majority were male(66%), Caucasian(53%), had Child C cirrhosis(61%) or hepatocellular carcinoma(52%). The palliative care team was consulted in only 18 of the 107 patients(17%) who died or were removed, 89% of which occurred as inpatients. Half of these consultations occurred within 72 h of death. In univariable analysis, patients of younger age, white race, and higher end-stage liver disease scores at time of listing and delisting were more likely to receive palliative care services. Only younger age [Odds ratio(OR) = 0.92; P = 0.02] and Caucasian race(OR = 4.90; P = 0.02) were still associated with integration of palliative care services through multivariable analysis.CONCLUSION Palliative care services are grossly underutilized in older, non-white patients with cirrhosis on the liver transplant wait-list. We encourage early integration of these services into clinical decision-making in the transplant population, with further studies aimed at understanding barriers to consultation. | Priya Kathpalia Alexander Smith Jennifer C Lai | 2016 | World Journal of Transplantation2016，6，3： | 3 |
| 6 | Development of Soda Residue Concrete Expansion Agent显示文摘A new type of concrete expansion agent has been successfully developed for the first time in the world by utilizing an industrial waste residue soda residue and an industrial wasteliquor.Adding 3%-6% of the agent into Portland cement enables a shrinkage compensating concrete to be prepared.Mortar and concrete containing this expansion agent have better shrinkage compensating and mechanical properties.The raw materials component,production process,technical properties,micro analysis of mortar made with this expansion agent,mechanism of expansion and research results are described in this article.The experimental results show that the new type of concrete expansion agent accords with the standard and its main mineral component is xCaO ySO 3 zAl 2O 3. | 王宝民 M F Mohd Zain F C Lai | 2003 | Journal of Wuhan University of Technology(Materials Science)2003，18，3： | 3 |
| 7 | On the dexterity of robotics manilulators-service angle显示文摘 | Yang D C H Lai Z C | 1985 | ASME Journal of Mechanisms Transmissions and Automation in Design1985，107，3： | 2 |
| 8 | Fuzzy weighting optimization with several objective function in structual design显示文摘 | Shih C J Lai T K | 1994 | Computer & Structures1994，52，5： | 2 |
| 9 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 10 | Excited - state properties of dioxorhenium(V) generation and reactivity of dioxorhenium(Ⅵ) 显示文摘 | Che C M Chung W C Lai T F | 1989 | Inorg Chem1989，28，： | 1 |
| 11 | Does dying at home influence the good death of terminal cancer patients? 显示文摘 | Yao C A Hu W Y Lai Y F | 2007 | J Pain Symptom Manage2007，34，5： | 1 |
| 12 | Tarsal sinus: arthrographic, MR imaging, MR arthrographic, and pathologic findings in cadavers and retrospective study data in patients with sinus tarsi syndrome显示文摘 | Lektrakul N Chung C B Lai Y M | 2001 | Radiology2001，219，6： | 1 |
| 13 | Connectivity distribution and attack tolerance of general networks with both preferential and random attachments显示文摘 | Liu Y C Lai Y C Ye N | 2002 | Physics Letters A2002，303，： | 1 |
| 14 | Brake squeal a literature review 显示文摘 | Papinniemi Antti Lai Joseph C S Zhao Jiye | 2002 | Applied Acoustics2002，63，4： | 1 |
| 15 | Mathematical modelling of elliptic helicoid screw transmission systems显示文摘 | Wu D S Lai H Y Chen C K | 2002 | Proceedings of the Institution of Mechanical Engineers Part B: Journal of Engineering Manufacture2002，216，2： | 1 |
| 16 | Controlling chaotic dynamical systems显示文摘 | Lai Ying-Cheng | 1999 | Systems & Control Letters1999，，31： | 1 |
| 17 | Management of recurrent cervical cancer显示文摘 | Lai C H | 2004 | Chang Gung Med J2004，27，10： | 1 |
| 18 | Matrix profile and wavefront reduction based on the graph theory and wavefront minimization显示文摘 | Lai Y C Weingarten V I Eshraghi H | 1996 | International Journal for Numerical Methods in Engineering1996，39，7： | 1 |
| 19 | Current approaches to the management of acute primary angle-closure glaucoma显示文摘 | LAM D S THAM C C LAI J S | 2007 | Curr Opin Opthalmol2007，18，2： | 1 |
| 20 | Neural network models for product image design显示文摘 | Lin Y C Lai H H Yeh C H | 2004 | Knowledge-Based Intelligent Information and Engineering Systems2004，，3215： | 1 |
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