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1篇 您的检索式:作者名="Lavinia Ferrone"
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1Plasma small-extracellular vesicles enriched in miR-122-5p promote disease aggressiveness in pediatric anaplastic large-cell lymphoma显示文摘Dear Editor,Anaplastic lymphoma kinase-positive(ALK+)anaplastic large cell lymphoma(ALCL)is an aggressive peripheral Tcell lymphoma representing 10%-15%of pediatric lymphoid neoplasms.The constitutively activated nucleophosmin-ALK(NPM-ALK)fusion protein is the main driver of ALK+ALCL oncogenesis[1].Current clinical protocols can achieve high cure rates,with 75%event-free survival(EFS)at 5 years[2],but the patients’outcome with relapsed/refractory disease still remains poor[3].Liquid biopsy is widely applied for the prognostic and therapeutic stratification of onco-hematological patients.As a non-invasive procedure,it can be used to identify several biomarkers,such as small extracellular vesicles(S-EVs)[4].S-EVs are stable carriers of molecules that mediate genetic exchange between distant cells,alter the microenvironment,facilitate cancer cell progression and promote drug resistance[5].Carlotta Caterina Damanti Lavinia Ferrone Enrico Gaffo Anna Garbin Anna Tosato Giorgia Contarini Ilaria Gallingani Roberta Angioni Barbara Molon Giulia Borile Elisa Carraro Marta Pillon Federico Scarmozzino Angelo Paolo Dei Tos Marco Pizzi Francesco Ciscato Andrea Rasola Alessandra Biffi Stefania Bortoluzzi Federica Lovisa Lara Mussolin 2023Cancer Communications2023,43,5:0
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