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| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | 电弧防护服防护性能测量显示文摘 1 概述
在过去10年里,人们对电弧事故的本质以及电弧对附近工人造成的人身伤害等方面的认知取得了显著进展.电弧造成的人身伤害,除了有触电和电击等显著伤害外,还有其他相对不直观的伤害,如电弧事故中形成的热效应.热效应是由电弧产生的较大比例的热辐射引起的,肉眼不可见,所以相对不直观;但是却可能对人体皮肤造成一定程度的灼伤,甚至导致更严重或致命的伤害.…… | Genevieve Laverty | 2008 | 电力安全技术2008，10，9： | 10 |
| 3 | Mucoadhesive polymeric platforms for controlled drug delivery显示文摘 | Andrews GP Laverty TP Jones DS | 2009 | Eur J Pharm Biopharm2009，71，3： | 1 |
| 4 | Active travel to work and cardiovascular risk factors in the United Kingdom显示文摘 | Laverty AA Mindell JS Webb EA | 2013 | Am J Prey Med2013，45，3： | 1 |
| 5 | PTH stimulatesa C1^- -dependent and EIPA-sensitive current in chick proximal tubule cells in culture 显示文摘 | LAVERTY G MCWILLIAMS C SHELDON A | 2003 | Am J Physiol Renal Physiol2003，284，5： | 1 |
| 6 | Cleavage of type Ⅱ collagen by cathepsin K in human osteoarthritic cartilage显示文摘 | Dejica VM Mort JS Laverty S | 2008 | Am J Pathol2008，173，1： | 1 |
| 7 | Evaluation of the CytoRich slide preparation process 显示文摘 | Laverty CR Farnsworth A Thurloe JK | 1997 | Anal Quant Cytol Histol1997，19，3： | 1 |
| 8 | Evidence for alteredsynthesis of type II collagen in patients with osteoarlhritis显示文摘 | FNelson L Dahlberg S Laverty A Reiner | 1998 | J Clin In-vest1998，，12： | 1 |
| 9 | Mucoadhesive polymeric platforms for controlled drug detivery 显示文摘 | Andrews GP Laverty TP Jones DS | 2009 | Eur J Pharm Biopharm2009，71，： | 1 |
| 10 | Managerial myopia or systemic short-tremism显示文摘 | Laverty K J | 2004 | Management Decision2004，42，8： | 1 |
| 11 | Cleavage of typeⅡcol agen by cathepsin K in human osteoarthritic cartilage显示文摘 | Dejica VM Mort JS Laverty S | | 0，，01： | 1 |
| 12 | Film boiling of saturated nitrogen flowing in a vertical tube 显示文摘 | LAVERTY W F ROHSENOW W M | 1967 | ASME Journal of Heat Transfer1967，89，1： | 1 |
| 13 | Ex vivo characterization of articular cartilage and bone lesions in a rabbit ACL transection model of osteoarthritis using MRI and micro-CT 显示文摘 | Batiste DL Kirkley A Laverty S | 2004 | Osteoarthritis Cartilage2004，12，12： | 1 |
| 14 | Aldosterone suppresses expression of an avian colonic sodium-glucose cotransporter 显示文摘 | Laverty G Bjarnadottir S Elbr^TM nd V S | 2001 | Am J Physiol2001，281，： | 1 |
| 15 | An improved algorithm to aid in post-heat storm restoration显示文摘 | Laverty E Schulz N N | 1999 | IEEE Trans on Power System1999，14，2： | 1 |
| 16 | The MSL complex: X chromosome and beyond 显示文摘 | Laverty C Lucci J Akhtar A | 2010 | Curr Opin Genet Dev2010，20，2： | 1 |
| 17 | Epstein-Barr virus encoded latent membrane protein-1 induces epithelial cell proliferation and sensitizes transgenic mice to chemical carcinogenesis显示文摘 | Curran JA Laverty FS Campbell D | 2001 | Cancer Res2001，61，18： | 1 |
| 18 | Synchrophasor broadcast over intemet protocol for distributed generator synchro- nization显示文摘 | BEST R J MORROW D J LAVERTY D M | 2010 | IEEE Transanction on Power Delivery2010，25，4： | 1 |
| 19 | the importance of the cell sample in cervical cytology: a controlled trail of a new sampling device显示文摘 | Laverty CR Farnsworth A Thurloe JK | 1989 | Med J Aust1989，150，8： | 1 |
| 20 | Laparoscopic Abdominal A natomy of Foals Positioned in Dorsal Recumbency 显示文摘 | Boure L Marcoux M Laverty S | 1997 | Vet Surg1997，26，1： | 1 |
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