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| 1 | Appropriate prescribing in the elderly: Current perspectives显示文摘Advances in medical therapeutics have undoubtedly contributed to health gains and increases in life expectancy over the last century. However, there is growing evidence to suggest that therapeutic decisions in older patients are frequently suboptimal or potentially inappropriate and often result in negative outcomes such as adverse drug events, hospitalisation and increased healthcare resource utilisation. Several factors influence the appropriateness of medication selectionin older patients including age-related changes in pharmacokinetics and pharmacodynamics, high numbers of concurrent medications, functional status and burden of co-morbid illness. With ever-increasing therapeutic options, escalating proportions of older patients worldwide, and varying degrees of prescriber education in geriatric pharmacotherapy, strategies to assist physicians in choosing appropriate pharmacotherapy for older patients may be helpful. In this paper, we describe important age-related pharmacological changes as well as the principal domains of prescribing appropriateness in older people. We highlight common examples of drugdrug and drug-disease interactions in older people. We present a clinical case in which the appropriateness of prescription medications is reviewed and corrective strategies suggested. We also discuss various approaches to optimising prescribing appropriateness in this population including the use of explicit and implicit prescribing appropriateness criteria, comprehensive geriatric assessment, clinical pharmacist review, prescriber education and computerized decision support tools. | Amanda Hanora Lavan John O'Grady Paul Francis Gallagher | 2015 | World Journal of Pharmacology2015，4，2： | 3 |
| 2 | Multiple-tuned mass dampers for multimodal control of pedestrian bridges 显示文摘 | Daniel Y Lavan O Levy R | 2012 | Journal of Structure Engineering2012，138，： | 1 |
| 3 | Iron status and restless legs syndrome in the elderly 显示文摘 | O' Keeffe ST Gavin K Lavan JN | 1994 | Age Ageing1994，23，3： | 1 |
| 4 | Iron status and restless legs syndrome in the elderly 显示文摘 | O'Keeffe ST Gavin K Lavan JN | 1994 | Age Ageing1994，23，3： | 1 |
| 5 | Fully Stressed Design of Passive Controllers in Framed Structures for Seismic Loadings显示文摘 | Levy R Lavan O | 2006 | Structural and Multidisciplinary Optimization2006，32，6： | 1 |
| 6 | Simple iterative use of lyapunov's solution for the linear optimal seismic design of passive devices in framed buildings显示文摘 | Lavan O Levy R | 2009 | Journal of Earthquake Engineering2009，13，5： | 1 |
| 7 | Multi-objective evolutionary seismic design with passive energy dissipation systems显示文摘 | Lavan O Dargush G F | 2009 | Journal of Earthquake Engineering2009，13，6： | 1 |
| 8 | Optimal Design of Supplemental Viscous Dampers for Irregular Shear-frames in the Presence of Yielding 显示文摘 | LAVAN O LEVY R | 2005 | Earthquake Engineering Structural Dynamics2005，34，8： | 1 |
| 9 | Quantitative comparison of optimization approaches for the design of supplemental damping in earthquake engineering practice显示文摘 | Levy R Lavan O | 2009 | ASCE Journal of Structural Engineering2009，135，3： | 1 |
| 10 | Iron status and restless legs syndrome in the elderly显示文摘 | O' Keefe ST Gavin K Lavan JN | 1994 | Age and Ageing1994，23，3： | 1 |
| 11 | Iron status and rest-less legs syndrome in the elderly 显示文摘 | O^eeffe S T Gavin K Lavan J N | 1994 | Age Ageing1994，23，3： | 1 |
| 12 | h'on status and restless legs syndrome in the elderly 显示文摘 | O' Keeffe ST Gavin K Lavan JN | 1994 | Age Aging1994，23，3： | 1 |
| 13 | Clinical significance of delirium subtypes in older people显示文摘 | O'Keeffe ST Lavan JN | | 0，，： | 1 |
| 14 | Optimal design of supplemental viscous dampers for irregular shear-frames in the presence of yielding 显示文摘 | Lavan O Levy R | | Earthquake Engineering & Structural Dynamics0，34，： | 1 |
| 15 | The prognostic significance of delirium in older hospital patients显示文摘 | O'Keeffe S Lavan J | 1997 | J Am Geriatr Soc1997，45，2： | 1 |
| 16 | Iron status and restless legs syndrome in the elderly显示文摘 | O'Keeffe ST Gavin K Lavan JN | 1994 | Age Aging1994，23，3： | 1 |
| 17 | Optimal design of supplemental viscous dampers for irregular shear-frames in the presence of yielding显示文摘 | Lavan O Levy R | 2005 | Earthquake Engineering & Structural Dynamics2005，34，8： | 1 |
| 18 | Simple iterafive use of Lyapunov's solution for the linear optimal seismic design of passive devices in framed buildings显示文摘 | Lavan O Levy R | 2009 | Journal of Earthquake Engineering2009，13，5： | 1 |
| 19 | Predicting delirium in elderly patients: development and validation of a risk-stratification model 显示文摘 | O'Keeffe ST Lavan JN | 1996 | Age Ageing1996，25，4： | 1 |
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