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16篇 您的检索式：作者名="Laudier"

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		题名	作者	年代	出处	被引量
	1	Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation显示文摘Mesenchymal stem cell(MSC)-based treatments have shown promise for improving tendon healing and repair.MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes. Cell elongation and cytoskeletal tension have been shown to be instrumental to the process of MSC differentiation. Previous studies have shown that inhibition of stress fiber formation leads MSCs to default toward an adipogenic lineage, which suggests that stress fibers are required for MSCs to sense the environmental factors that can induce differentiation into tenocytes. As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, we examined whether the activation of this pathway was required when inducing MSC tendon differentiation using rope-like silk scaffolds. To accomplish this, we employed a loss-of-function approach by knocking out ROCK,actin and myosin(two other components of the pathway) using the specific inhibitors Y-27632, Latrunculin A and blebbistatin, respectively. We demonstrated that independently disrupting the cytoskeleton and the Rho/ROCK pathway abolished the expression of tendon differentiation markers and led to a loss of spindle morphology. Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds.	Edward Maharam Miguel Yaport Nathaniel L Villanueva Takintope Akinyibi Damien Laudier Zhiyong He Daniel J Leong Hui B Sun	2015	Bone Research2015，3，3：	4
	2	High-dose risedronate treatment partially preserves cancellous bone mass and microarchitecture during long-term disuse显示文摘	Li C Y Majeska R J Laudier D M	2005	Bone2005，37，3：	1
	3	A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture显示文摘	Natalia Maldonado Adreanne Kelly-Arnold Yuliya Vengrenyuk Damien Laudier John T. Fallon Renu Virmani Luis Cardoso Sheldon Weinbaum	2012	AJP: Heart and Circulatory Physiology2012，，5：	1
	4	Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes 显示文摘	Illien-Junger S Grosjean F Laudier DM	2013	PloS One2013，8，64：	1
	5	PMX2B,a new candidate gene for Hirschsprung's disease 显示文摘	Benailly HK Lapierre JM Laudier B	2003	Clin Genet2003，64，3：	1
	6	Meiotic segregation analysis in spermatozoa of perieentric inversion carriers using fluorescence in-situ hybridization 显示文摘	Morel F Laudier B Gu6rif F	2007	Hum Reprod2007，22，1：	1
	7	Meiotic segregation analysis in spermatozoa of pericentric inversion carriers using fluorescence insitu hybridization显示文摘	Morel F Laudier B GuerifF	2007	Hum Reprod2007，22，1：	1
	8	Revised micro- calcification hypothesis for fibrous cap rupture in human coronary ar- teries显示文摘	Kelly-Arnold A Maldonado N Laudier D	2013	Proc Natl Acad Sci U S A2013，10，10：	1
	9	Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome 显示文摘	AmielJ Laudier B Attie-Bitach T	2003	Nat Gcnet2003，33，4：	1
	10	A sanitised city? Social exclusion at Bristol' s 1996 International Festival of the Sea显示文摘	Atkinson D Laudier E	1998	Geoforum1998，29，2：	1
	11	Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion显示文摘	Daniel J. Leong Xiang I. Gu Yonghui Li Jonathan Y. Lee Damien M. Laudier Robert J. Majeska Mitchell B. Schaffler Luis Cardoso Hui B. Sun	2010	Matrix Biology2010，，5：	1
	12	Activation of resorption in fatigue-loaded bone involves both apop- tosis and active pro-osteoclastogenic signaling by dis- tinct osteocyte cell populations 显示文摘	Kennedy OD Herman BC Laudier DM	2012	Bone2012，50，5：	1
	13	Revised mierocalcification hypothesis for fibrous cap rupture in human coronary arteries显示文摘	Kelly-Arnold A Maldonado N Laudier D	2013	Proc Natl Acad Sci USA2013，110，10：	1
	14	High-dose risedronate treatment partially preserves cancellous bone mass and microarchitecture during long-term disuse显示文摘	Yang Li C Majeska RJ Laudier DM		0，，03：	1
	15	Polyalanine expansion and frameshift mutations of the paired like homeobox gene PHOX2B in congenital central hypoventilation syndrome显示文摘	Amiel J Laudier B Attie-Bitach T	2003	Nat Genet2003，33，：	1
	16	Meiotic segregation analysis in spermatozoa of pericentric inversion carriers using fluorescence in-situ hybridization 显示文摘	MOREL F LAUDIER B GUERIF F	2007	Hum Reprod2007，22，：	1

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