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| 1 | Paraneoplastic syndrome in mice bearing high-angiogenic variant of Lewis lung carcinoma: Relations with tumor derived VEGF显示文摘 | Fedorchuk Olexander G Pyaskovskaya Olga M Skivka Larysa M | 2012 | Cytokine2012，57，1： | 1 |
| 2 | Introduction of antineoplastic drug NSC631570 in an inpatient and outpatient setting:Comparative evaluation of biological effects显示文摘The aim of this study is to evaluate the effect of moderate physical exercise and treatment time on the organism’s response to NSC631570. The sensitivity of circulating phagocytes to the drug at different times of day was estimated in in vitro experiments. NSC631570 was administered intravenously to healthy volunteers (eleven men, 23 ± 2 years) in a single therapeutic dose in an inpatient and an outpatient setting. Blood samples were obtained before the drug administration, 30 min after the drug injection and every fourth hour throughout the 24 hour period. Biochemical parameters were determined using the hematological analyzer. Flow cytometry was used to evaluate phagocyte metabolism. Treatment of circulating phagocytes with NSC631570 in vitro resulted in an increase in ROS production along with a decrease in their phagocytic activity, most expressed in the morning time. Drug injection to sedentary persons resulted in pro-inflammatory metabolic polarization of circulating phagocytes. Introduction of NSC631570 to active persons was accompanied by a significant increase in phagocyte endocytosis along with a decrease in the daily mean of ROS generation. Significant oscillation (but in the normal ranges) of urea, creatinine, alanine aminotransferase and aspartate aminotransferase after NSC631570 introduction in the outpatient setting was shown during the day. Physical activity interferes with immunomodulatory action of NSC631570 and abrogates pro-inflammatory shift of circulating phagocytes. Biochemical parameters of blood from patients treated with NSC631570 in the outpatient setting must be interpreted cautiously considering the effect of physical activity on some metabolic biomarkers. | Mariia Rudyk Olexander Fedorchuk Yaroslav Susak Yaroslav Nowicky Larysa Skivka | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，2： | 0 |
| 3 | Routine laboratory parameters in patients with necrotizing pancreatitis by the time of operative pancreatic debridement:Food for thought显示文摘BACKGROUND Timing of invasive intervention such as operative pancreatic debridement(OPD)in patients with acute necrotizing pancreatitis(ANP)is linked to the degree of encapsulation in necrotic collections and controlled inflammation.Additional markers of these processes might assist decision-making on the timing of surgical intervention.In our opinion,it is logical to search for such markers among routine laboratory parameters traditionally used in ANP patients,considering simplicity and cost-efficacy of routine laboratory methodologies.AIM To evaluate laboratory variables in ANP patients in the preoperative period for the purpose of their use in the timing of surgery.METHODS A retrospective analysis of routine laboratory parameters in 53 ANP patients undergoing OPD between 2017 and 2020 was performed.Dynamic changes of routine hematological and biochemical indices were examined in the preoperative period.Patients were divided into survivors and non-survivors.Survivors were divided into subgroups with short and long post-surgery length of stay(LOS)in hospital.Correlation analysis was used to evaluate association of laboratory variables with LOS.Logistic regression was used to assess risk factors for patient mortality.RESULTS Seven patients(15%)with severe acute pancreatitis(SAP)and 46 patients(85%)with moderately SAP(MSAP)were included in the study.Median age of participants was 43.2 years;33(62.3%)were male.Pancreatitis etiology included biliary(15%),alcohol(80%),and idiopathic/other(5%).Median time from diagnosis to OPD was≥4 wk.Median postoperative LOS was at the average of 53 d.Mortality was 19%.Progressive increase of platelet count in preoperative period was associated with shortened LOS.Increased aspartate aminotransferase and direct bilirubin(DB)levels the day before the OPD along with weak progressive decrease of DB in preoperative period were reliable predictors for ANP patient mortality.CONCLUSION Multifactorial analysis of dynamic changes of routine laboratory variables can be useful for a person-tailored timing of surgical intervention in ANP patients. | Yaroslav M Susak Kristina Opalchuk Olexandr Tkachenko Mariia Rudyk Larysa Skivka | 2022 | World Journal of Gastrointestinal Surgery2022，14，1： | 0 |
| 4 | C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance显示文摘我们与 C 60 fullerene (C 60+Cis 建筑群) 提出了并且分析并且在 vitro 向肿瘤房间线看了它的更高的毒性是否 anticancer 药 cisplatin (Cis ) 的新奇 nanoformulation 与 Cis 相比独自一个。建筑群的最高的毒性在 HL-60/adr 和 HL-60/vinc 被观察化疗抵抗的人的白血病房间 sublines (对 Adriamycin 和 Vinculin 抵抗,分别地) 。我们发现 C 60+Cis 建筑群的行动与通过在 Annexin V/PI 试金观察 apoptotic 房间的一个增加的数字克服肿瘤房间线的药抵抗被联系。而且,在与路易斯一起的 vivo 试金,肺癌(LLC ) C57BL/6J 雄的老鼠证明 C 60+Cis 建筑群增加肿瘤生长抑制,什么时候与 Cis 或 C 60 fullerenes 相比独自一个。同时,我们进行了分子的停靠研究并且执行了 Ames 测试。分子的停靠指定 C 60 fullerene 的能力在 P-glycoprotein (P-gp ) 上与潜在的有约束力的地点形成货车 der Waals 相互作用, multidrug 抵抗蛋白质 1 (MRP-1 ) ,并且 multidrug 抵抗蛋白质 2 (MRP-2 ) 分子。观察现象揭示了可能的机制由 C 60+Cis 建筑群绕过肿瘤房间药抵抗。另外, Ames 测试的结果证明如此的建筑群的形成减少 Cis 诱变的活动并且可以减少第二等的瘤形成的概率。在结论, C 60+Cis 建筑群有效地在 vitro 导致了肿瘤细胞死亡并且在 vivo 禁止了肿瘤生长,由与 P-gp, MRP-1,和 MRP-2 分子交往的 C 60 fullerene 的潜力多半克服药抵抗。因此, C 60+Cis 建筑群可能是潜在的新奇化疗修正。 | Svitlana Prylutska Rostyslav Panchuk Grzegorz Golunski Larysa Skivka Yuriy Prylutskyy Vasyl Hurmach Nadya Skorohyd Agnieszka Borowik Anna Woziwodzka Jacek Piosik Olena Kyzyma Vasil Garamus Leonid Bulavin Maxim Evstigneev Anatoly Buchelnikov Rostyslav Stoika Walter Berger Uwe Ritter Peter Scharff | 2017 | Nano Research2017，10，2： | 0 |
| 5 | Effectiveness of a new approach to minimally invasive surgery in palliative treatment of patients with distal malignant biliary obstruction显示文摘BACKGROUND Palliative endoscopic biliary drainage is the primary treatment option for the management of patients with jaundice which results from distal malignant biliary obstruction(DMBO).In this group of patients,decompression of the bile duct(BD)allows for pain reduction,symptom relief,chemotherapy administration,improved quality of life,and increased survival rate.To reduce the unfavorable effects of BD decompression,minimally invasive surgical techniques require continuous improvement.AIM To develop a technique for internal-external biliary-jejunal drainage(IEBJD)and assess its effectiveness in comparison to other minimally invasive procedures in the palliative treatment of patients with DMBO.METHODS A retrospective analysis of prospectively collected data was performed,which included 134 patients with DMBO who underwent palliative BD decompression.Biliary-jejunal drainage was developed to divert bile from the BD directly into the initial loops of the small intestine to prevent duodeno-biliary reflux.IEBJD was carried out using percutaneous transhepatic access.Percutaneous transhepatic biliary drainage(PTBD),endoscopic retrograde biliary stenting(ERBS),and internal-external transpapillary biliary drainage (IETBD) were used for the treatment of studypatients. Endpoints of the study were the clinical success of the procedure, the frequency andnature of complications, and the cumulative survival rate.RESULTSThere were no significant differences in the frequency of minor complications between the studygroups. Significant complications occurred in 5 (17.2%) patients in the IEBJD group, in 16 (64.0%)in the ERBS group, in 9 (47.4%) in the IETBD group, and in 12 (17.4%) in the PTBD group.Cholangitis was the most common severe complication. In the IEBJD group, the course ofcholangitis was characterized by a delayed onset and shorter duration as compared to other studygroups. The cumulative survival rate of patients who underwent IEBJD was 2.6 times higher incomparison to those of the PTBD and IETBD groups and 20% higher in comparison to that of theERBS group.CONCLUSIONIEBJD has advantages over other minimally invasive BD decompression techniques and can berecommended for the palliative treatment of patients with DMBO. | Yaroslav M Susak Leonid L Markulan Serhii M Lobanov Roman Y Palitsya Mariia P Rudyk Larysa M Skivka | 2023 | World Journal of Gastrointestinal Surgery2023，15，4： | 0 |
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