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| 1 | 儿童和成人住院期间心脏骤停时首次确诊的心脏节律与临床结局显示文摘Context: Cardiac arrests in adults are often due to ventricular fibrillation(VF) or pulseless ventricular tachycardia(VT), which are associated with better outcomes than asystole or pulseless electrical activity(PEA). Cardiac arrests in children are typically asystole or PEA. Objective: To test the hypothesis that children have relatively fewer in-hospital cardiac arrests associated with VF or pulseless VT compared with adults and, therefore, worse survival outcomes. Design, Setting, and Patients: A prospective observational study from a multicenter registry(National Registry of Cardiopulmonary Resuscitation) of cardiac arrests in 253 US and Canadian hospitals between January 1, 2000, and March 30, 2004. A total of 36 902 adults(≥ 18 years) and 880 children(<18 years) with pulseless cardiac arrests requiring chest compressions, defibrillation, or both were assessed. Cardiac arrests occurring in the delivery department, neonatal intensive care unit, and in the out-of-hospital setting were excluded. Main Outcome Measure: Survival to hospital discharge. Results: The rate of survival to hospital discharge following pulseless cardiac arrest was higher in children than adults(27% [236/880] vs 18% [6485/36 902]; adjusted odds ratio[OR], 2.29; 95% confidence interval[CI], 1.95- 2.68). Of these survivors, 65% (154/236) of children and 73% (4737/6485) of adults had good neurological outcome. The prevalence of VF or pulseless VT as the first documented pulseless rhythm was 14% (120/880) in children and 23% (8361/36 902) in adults(OR, 0.54; 95% CI, 0.44- 0.65; P<.001). The prevalence of asystole was 40% (350) in children and 35% (13 024) in adults(OR, 1.20; 95% CI, 1.10- 1.40; P=.006), whereas the prevalence of PEA was 24% (213) in children and 32% (11 963) in adults(OR, 0.67; 95% CI, 0.57- 0.78; P< .001). After adjustment for differences in preexisting conditions, interventions in place at time of arrest, witnessed and/or monitored status, time to defibrillation of VF or pulseless VT, intensive care unit location of arrest, and duration of cardiopulmonary resuscitation, only first documented pulseless arrest rhythm remained significantly associated with differential survival to discharge(24% [135/563] in children vs 11% [2719/24 987] in adults with asystole and PEA; adjusted OR, 2.73; 95% CI, 2.23- 3.32). Conclusions: In this multicenter registry of in-hospital cardiac arrest, the first documented pulseless arrest rhythm was typically asystole or PEA in both children and adults. Because of better survival after asystole and PEA, children had better outcomes than adults despite fewer cardiac arrests due to VF or pulseless VT. | Nadkarni V. M Larkin G. L Peberdy M. A 刘宇(译) 马超(校) | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，5： | 2 |
| 2 | Loop electrosurgical excision procedure of the cervix and time of delivery in subsequent pregnancy 显示文摘 | Sciscione A Larkin M OShea A | 2004 | Am J Obstet Gynecol2004，190，3： | 1 |
| 3 | Positive and negative regulation of the IL-27 receptor during lymphoid cell activation 显示文摘 | VILLARINO A V LARKIN J 3RD SARIS C J | 2005 | J Inmmnol2005，174，12： | 1 |
| 4 | Partial characterization of the acidic and basic polypeptides of glycinin 显示文摘 | Moreira M A Hermodson M A Larkins B A | 1979 | Journal of Biological Chemistry1979，254，： | 1 |
| 5 | ClustalW2 and ClustalX version 2 显示文摘 | Larkin M A Blackshields G Brown N P | 2007 | Bioinformatics2007，23，： | 1 |
| 6 | Microsatellites and a single nucleotide polymorphism differetiate apparent amylose classes in an extended pedigree of US rice germplasm显示文摘 | Ayres N M McClung A M Larkin P D | 1997 | Theor Appl Genet1997，94，： | 1 |
| 7 | TNF receptor secretion after ex vivo adenoviral gene transfer to cornea and effect on in vivo graft survival显示文摘 | RAYNERS A LARKIN D F GEORGE A J | 2001 | Invest Ophthalmol Vis Sci2001，42，7： | 1 |
| 8 | Positive and negative regulation of the IL-27 receptor during lymphoid cell activation显示文摘 | VILLARINO A V LARKIN J RD SARIS C J | 2005 | J Immunol2005，174，12： | 1 |
| 9 | lmmuno-oneology Combina- tions:A Review of Clinical Experience and Future Prospects显示文摘 | Antonia S J Larkin J Ascierto P A | 2014 | Clin Cancer Res2014，20，24： | 1 |
| 10 | The eEFIA gene family is differentially expressed in maize endosperm显示文摘 | CARNEIRO N P HUGHES P A LARKINS B A | 1999 | Plant Mol Biol1999，41，6： | 1 |
| 11 | Elongation factor 1 alpha concentration is highly correlated with the lysine content of maize endosperm显示文摘 | Habben J E Moro G L Hunter B G Hamaker B R Larkins B A | 1995 | Proceedings of The National Academy of USA1995，92，： | 1 |
| 12 | Partial characterization of the acidic and basic polypeptides of glycinin显示文摘 | Moreira M A Hermodson M A Larkins B A | 1979 | Journal of Biochemistry1979，254，： | 1 |
| 13 | Intrathecal fentanyl-induced pruritus is more severe in combination with procaine than with lidocaine or bupivacaine显示文摘 | Larkin KL Siddiqui A | 2001 | Reg Anesth Pain Med2001，26，3： | 1 |
| 14 | Elongation factor la concentration is highly correlated with the lysine content of maize endosperm显示文摘 | HABBEN J E MORO G L HUNTER B G HAMAKER B R LARKINS B A | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 15 | Imperfect perfect lens 显示文摘 | LARKIN I A STOCKMAN M I | 2005 | Nano Lett2005，5，： | 1 |
| 16 | Theory of collective flux creep显示文摘 | Feigel’man M V Geshkenbein V B Larkin A I | 1989 | Phys Rev Lett1989，63，： | 1 |
| 17 | The opaque-2 mu- tation of maize differentially reduces zein gene transcrip- tion显示文摘 | Kodrzycki R Boston R S Larkins B A | 1989 | Plant Ce111989，1，1： | 1 |
| 18 | EGFR and HER2 inhibition in pancreatic cancer显示文摘 | Walsh N Kennedy S Larkin A | | Invest New Drugs0，31，3： | 1 |
| 19 | Microsatellites and a single-nucleotide polymorphism in an extended pedigree of US rice germplasm 显示文摘 | Ayres N M McClung A M Larkin P D | 1997 | Theoretical and Applied Genetics1997，94，： | 1 |
| 20 | Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear tactor kappaB activation 显示文摘 | Brooks SV Vasilaki A Larkin LM | 2008 | J Physiol2008，586，16： | 1 |
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