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| 1 | Long-term albumin infusion improves survival in patients with cirrhosis and ascites: An unblinded randomized trial显示文摘瞄准:在幸存上调查长期的白朊管理的效果,腹水的复发和另外的复杂并发症的发作。方法:为第一发作的腹水招收的 100 个连续病人被使随机化加人的白朊收到利尿剂第一年和 25 g 里的 25 g/wk 每二 wk 此后(组 1 ) 或利尿剂独自一个(组 2 ) 。没有肝移植,主要端点是幸存。第二等的端点是腹水的复发和另外的复杂并发症的出现。结果:中部的后续是 84 (2-120 ) 瞬间。对待白朊的病人有显著地更大的累积幸存率(Breslow test=7.05, P=0.0078 ) 并且腹水复发的更低的概率(51% 对 94% , P<0.0001 ) 。长期的白朊注入导致了 16 瞬间的幸存的吝啬的增加。结论:在第一发作的腹水以后的长期的白朊管理显著地改进病人的幸存并且减少腹水复发的风险。 | Roberto Giulio Romanelli Giorgio La Villa Giuseppe Barletta Francesco Vizzutti Fabio Lanini Umberto Arena Vieri Boddi Roberto Tarquini Pietro Pantaleo Paolo Gentilini Giacomo Laffi | 2006 | World Journal of Gastroenterology2006，12，9： | 22 |
| 2 | Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study显示文摘AIM To investigate the adhesion and anti-inflammatory effects of Lactobacil us rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture model.METHODS For the ex vivo experiment, a total of 98 patients (68 UC patients and 30 normal subjects) were included. Endoscopic biopsies were collected and incubated with and without LGG or LGG-conditioned media to evaluate the mucosal adhesion and anti-inflammatory effects [reduction of tumor necrosis factor alpha (TNFα) and interleukin (IL)-17 expression] of the bacteria, and extraction of DNA and RNA for quantification by real-time (RT)-PCR occurred after the incubation. A dose-response study was performed by incubating biopsies at 'regular', double and 5 times higher doses of LGG. For the in vivo experiment, a total of 42 patients (20 UC patients and 22 normal controls) were included. Biopsies were taken from the colons of normal subjects who consumed a commercial formulation of LGG for 7 d prior to the colonoscopy,and the adhesion of the bacteria to the colonic mucosa was evaluated by RT-PCR and compared with that of control biopsies from patients who did not consume the formulation. LGG adhesion and TNFα and IL-17 expression were compared between UC patients who consumed a regular or double dose of LGG supplementation prior to colonoscopy.RESULTS In the ex vivo experiment, LGG showed consistent adhesion to the distal and proximal colon in normal subjects and UC patients, with a trend towards higher concentrations in the distal colon, and in UC patients, adhesion was similar in biopsies with active and quiescent inflammation. In addition, bioptic samples from UC patients incubated with LGG conditioned media (CM) showed reduced expression of TNFα and IL-17 compared with the corresponding expression in controls (P < 0.05). Incubation with a double dose of LGG increased mucosal adhesion and the anti-inflammatory effects (P < 0.05). In the in vivo experiment, LGG was detectable only in the colon of patients who consumed the LGG formulation, and bowel cleansing did not affect LGG adhesion. UC patients who consumed the double LGG dose had increased mucosal concentrations of the bacteria and reduced TNFα and IL-17 expression compared with patients who consumed the regular dose (48% and 40% reduction, respectively, P < 0.05).CONCLUSION In an ex vivo organ culture model, LGG showed consistent adhesion and anti-inflammatory effects. Colonization by LGG after consumption for a week was demonstrated in vivo in the human colon. Increasing the administered dose increased the adhesion and effectiveness of the bacteria. For the first time, we demonstrated that LGG effectively adheres to the colonic mucosa and exerts antiinflammatory effects, both ex vivo and in vivo. | Cristiano Pagnini Vito Domenico Corleto Michela Martorelli Claudio Lanini Giancarlo D'Ambra Emilio Di Giulio Gianfranco Delle Fave | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 3 | Healthcare - associated infection in Italy: annual point - prevalence surveys,2002 ~ 2004 显示文摘 | Lanini S Jarvis WR Nicastri E | 2009 | Infect Cont Hosp Epidemiol2009，30，7： | 1 |
| 4 | Socio ~ hydrosystem modeling for integrated water ~ resources management-the Hérault catchments case study,southern France,Environmental Modeling and Software显示文摘 | Lanini S Courtois N | 2004 | 2004，，1172： | 1 |
| 5 | Fine map-ping of quantitative trait loci using selected overlapping recombi-nant chromosomes in an interspecies cross of tomato 显示文摘 | PATERSON A H DEVEMA J W LANINI B | 1990 | Genetics1990，124，： | 1 |
| 6 | Fine mapping of quantitative trait loci using selected overlapping recom- binant chromosomes, in an interspecies cross of tomato 显示文摘 | Paterson AH DeVerna JW Lanini B | 1990 | Genetics1990，124，： | 1 |
| 7 | Heahhcare associated infection in Italy: annual point prevalence surveys, 2002- 2004显示文摘 | Lanini S Jarvis WR Nicastri E | 2009 | Infect Control Hosp Epidemiol2009，30，： | 1 |
| 8 | Molecularepidemiology of a hepatitis C virus epidemic in ahaemodialysis unit : outbreak investigation and infectionoutcome显示文摘 | LANINI S ABBATE I PURO V | 2010 | BMC Infect Dis2010，10，： | 1 |
| 9 | Fine Mapping ofquantitative trait loci using selected overlapping recombinantchromosomes in an interspecies cross of tomato显示文摘 | Paterson A H DeVerna J W Lanini B | 1990 | Genetics1990，124，： | 1 |
| 10 | Patient transmission of hepati-tis B viris:a systematic review of reports on outbreaks be-tween 1992and 2007显示文摘 | Lanini S Puro v Lauria | 2009 | BMC medicine2009，4，8： | 1 |
| 11 | Discriminating weeds from processing tomato using visible and near-infrared spectroscopy 显示文摘 | Slaughter D C Lanini W T Giles D K | 2004 | Transactions of the ASAE2004，47，6： | 1 |
| 12 | Discriminating weeds from processing tomato plants using visible and near-infrared spectroscopy显示文摘 | Slaughter D C Lanini W T Giles D K | 2004 | Transactions of the ASAE2004，47，6： | 1 |
| 13 | Comparison of soil N availability and leaching potential,crop yields and weeds in organic,low-input and conventional farming systems in northern California显示文摘 | Poudel D D Horwarth W R Lanini W T | 2002 | Agriculture Ecosystems and Environment2002，90，： | 1 |
| 14 | Heahhcare- associated infection in Italy:annual point-prevalence surveys, 2002-2004显示文摘 | Lanini S Jarvis WR Nicastri E | 2009 | Infect Cont Hosp Epidemiol2009，30，7： | 1 |
| 15 | Fine mapping of quantitative trait loci using selected overlapping recombinant chromosomes in an interspecies cross of tomato显示文摘 | Paterson A H Deverna J W Lanini B | 1990 | Genetics1990，124，： | 1 |
| 16 | Patient to patient transmission of hepatitis B virus: a systematic review of reports on outbreaks between 1992 and 2007显示文摘 | Lanini S Puro V Lauria F N et al | 2009 | BMC medicine2009，7，： | 1 |
| 17 | Plant growth response to the phytotoxin viridiol produced by the fungus Gliocladium virens 显示文摘 | Jones R W Lanini W T Hancock J G | 1988 | Weed Science1988，36，： | 1 |
| 18 | Healthcalre - associated in- fection in Italy : annual point - prevalence surveys, 2002 - 2004 显示文摘 | Lanini S Jarvis WR Nicastri E | 2009 | Infect Control Hospital Epidemiol2009，30，7： | 1 |
| 19 | Heatthcare-associated infection in Italy: annual point-prevalence surveys,2002-2004 显示文摘 | Lanini S Jarvis WR Nicastri E | 2009 | Infect Control Hosp Epidemiol2009，30，7： | 1 |
| 20 | Comparison of soil N availability and leaching potential, crop yields and weeds in organic, low-input and conventional fanning systems in northern California显示文摘 | Poudel D D Horwath W R Lanini W T | 2002 | Agriculture Ecosystems &Environment2002，90，2： | 1 |
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