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| 1 | Outcome of patients with acute, necrotizing pancreatitis requiring drainage-does drainage size matter?显示文摘AIM:To assess the outcome of patients with acute necrotizing pancreatitis treated by percutaneous drainage with special focus on the influence of drainage size and number. METHODS:We performed a retrospective analysis of 80 patients with acute pancreatitis requiring percutaneous drainage therapy for infected necroses. Endpoints were mortality and length of hospital stay. The influence of drainage characteristics such as the median drainage size, the largest drainage size per patient and the total drainage plane per patient on patient outcome was evaluated. RESULTS:Total hospital survival was 66%. Thirty-four patients out of all 80 patients (43%) survived acute necrotizing pancreatitis with percutaneous drainage therapy only. Eighteen patients out of all 80 patients needed additional percutaneous necrosectomy (23%). Ten out of these patients required surgical necrosectomy in addition, 6 patients received open necrosectomy without prior percutaneous necrosectomy. Elective surgery was performed in 3 patients receiving cholecystectomy and one patient receiving resection of the parathyroid gland. The number of drainages ranged from one to fourteen per patient. The drainage diameter ranged from 8 French catheters to 24 French catheters. The median drainage size as well as the largest drainage size used per patient and the total drainage area used per patient did not show statistically significant influence on mortality. CONCLUSION:Percutaneous drainage therapy is an effective tool for treatment of necrotizing pancreatitis.Large bore drainages did not prove to be more effective in controlling the septic focus. | T Bruennler J Langgartner S Lang CE Wrede F Klebl S Zierhut S Siebig F Mandraka F Rockmann B Salzberger S Feuerbach J Schoelmerich OW Hamer | 2008 | World Journal of Gastroenterology2008，14，5： | 23 |
| 2 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 3 | Development of theory of mind and executive control 显示文摘 | Pemer J Lang B | 1999 | Trends Cogn Sci1999，3，9： | 1 |
| 4 | Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+acute myeloid leukemia显示文摘 | Arceci RJ Sande J Lange B | | 0，，： | 1 |
| 5 | Characterization and quantification of a pharyngo UES contractile reflex in cats显示文摘 | Medda B K Lang I M Dodds W J | 1994 | Am J Physiol1994，267，61： | 1 |
| 6 | Retroperitoneoscopic adrenalectomy without previous control of adrenal vein is feasible and safe for pheochromocytoma显示文摘 | Zhang X Lang B Ouyang J Z | 2007 | Urology2007，69，： | 1 |
| 7 | Posterior epistaxis identification of common bleeding sites 显示文摘 | Theoraton M A Mahesh B N Lang J | 2005 | Laryngol Scope2005，115，4： | 1 |
| 8 | Chemistry Communica- tions显示文摘 | Lang J W Kong L B Wu W J | 2008 | 42132008，4213，： | 1 |
| 9 | Bayesian ordinal and binary regression models with a parametric family of mixturelinks 显示文摘 | Lang J B | 1999 | Computational Statistics & Data Analysis1999，31，1： | 1 |
| 10 | Towards operational guidelines for over-threshold modeling 显示文摘 | Lang M Ouardab T B M J Bobee B | 1999 | Journal of Hydrology1999，255，： | 1 |
| 11 | Enhanced fracture toughness in layered microcomposites of Ce-ZrO2 and Al2O3显示文摘 | Marshall D B Ratto J J Lange F F | 1999 | JAm CermaSoc1999，74，12： | 1 |
| 12 | Morphological aspects of interactions between asbestos fibers and human mesothelial cell cytoskeleton显示文摘 | RUTTNER J R LANG A B GUT D R ct al | 1987 | Exp Cell Biol1987，55，6： | 1 |
| 13 | Bone mineral density and biochemical makers of bone metabolism in late onset rheumatoid arthritis and polymyalgia rheumatoid-a prospective study on the influence of glueocortieoid therapy 显示文摘 | Lange U Boss B Teichmann J | 2000 | Z Rheumatol2000，59，2： | 1 |
| 14 | Metabolic disturbances during short exercises in dermatomyositis revealed by real-time functional 31P magnetic resonance spectroscopy显示文摘 | Pfleiderer B Lange J Loske KD | | 0，，： | 1 |
| 15 | Epithelioidangiosarcoma of the spine : a case report of a rare bone tumor显示文摘 | Lang J Chen L Chen B | 2014 | Oncol Lett2014，7，6： | 1 |
| 16 | Development of theory of mind and executive control 显示文摘 | Perner J Lang B | 1999 | Trends Cogn Sci1999，3，9： | 1 |
| 17 | Experimental and theoretical studies of fabric compaction behavior in resin transfer molding 显示文摘 | Chen B Lang E J Chou T W | 2001 | Materials Science and Engineering: A2001，317，1： | 1 |
| 18 | Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humans显示文摘 | B(a)umer T Lange R Liepert J | 2003 | Neuroimage2003，20，1： | 1 |
| 19 | MMP12,lung function, and COPD in high risk populations 显示文摘 | Hunninghake G M Cho M H Tesfaigzi Y Soto - Quiros M E Avila L Lasky - Su J Stidley C Melen E Soderhall C Hallberg J Kull I KercJ Svartengren M Pershagen G Wickman M Lange C Demeo D L Hersh C P Klanderman B J Raby B A Sparrow D Shapiro S D Silverman E K Litonjua A A Weiss S T Celedon J C | 2009 | New England Journal of Medicine2009，361，27： | 1 |
| 20 | Immunotherapy with human monoclonal antibodies: fragment A specificity of polyclonal and monoclonal antibodies is crucial for full protection against tetanus toxin显示文摘 | Lang A B Cryz S J Schurch U | 1993 | J lmmunol1993，151，： | 1 |
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