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| 1 | 阿卡波糖治疗在日常临床工作中的有效性、安全性和被接受程度——对中国2型糖尿病患者的阿卡波糖上市后监测(英文)显示文摘此项上市后监测的目的是为了评价中国的2型糖尿病患者日常实际使用阿卡波糖的有效性、安全性和接受程度。中国共有231位临床医师招募了2 480例2型糖尿病患者参加了本次开放性、前瞻性,非对照、非随机的多中心研究。主要的疗效参数是阿卡波糖治疗后空腹和餐后血糖水平的变化以及HbA_(IC)水平的变化。大部分患者入组之前曾接受其他口服降糖药或胰岛素的治疗,并且在平均为13.5周的观察期内接受了降糖药物联合治疗。大部分患者阿卡波糖的起始剂量为50 mg,3次/日。在整个研究期间,阿卡波糖使空腹血糖浓度下降了56.1 mg/dl(18 mg/dl葡萄糖=1 mmol/L葡萄糖),餐后2 h血糖下降了111.3 mg/dl,HbA_(IC)下降了1.9%,体重下降0.9 kg。研究期间出现了76次阿卡波糖相关的不良事件,两例患者出现严重不良事件。主治医师对90.1%的患者做出“非常好”或“较好”的评价,患者对阿卡波糖的耐受性为89.1%,接受程度为87.1%。无论作为单药治疗还是和其他降糖药物合用,每天常规使用阿卡波糖对于中国的2型糖尿病患者是有效、安全和接受程度较好的。 | 苏胜偶 赵家军 张锦 邹大进 李红 盛正妍 梁干雄 Harald Landen | 2006 | 中华内分泌代谢杂志2006，22，6： | 16 |
| 2 | Epithelial ovarian cancer:An overview显示文摘Ovarian cancer is the second most common gyneco-logical cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions. | Arpita Desai Jingyao Xu Kartik Aysola Yunlong Qin Chika Okoli Ravipati Hariprasad Ugorji Chinemerem Candace Gates Avinash Reddy Omar Danner Geary Franklin Anachebe Ngozi Guilherme Cantuaria Karan Singh William Grizzle Charles Landen Edward E Partridge Valerie Montgomery Rice E Shyam P Reddy Veena N Rao | 2014 | World Journal of Translational Medicine2014，3，1： | 10 |
| 3 | Tumor-selective response to antibody-mediated targeting of alphaVbeta3 integrin in ovarian cancer 显示文摘 | Landen CN Kim TJ Lin YG | 2008 | Neoplasia2008，10，11： | 1 |
| 4 | Hard X-ray and hot electron environment in vacuum hohlraums at the National Ignition Facili ty显示文摘 | McDonald J W Suter L J Landen O L | 2006 | PhysPlasmas2006，，： | 1 |
| 5 | Genomic instability is associated with lack of telomerase activation in ovarian cancer 显示文摘 | Landen C N Klingelhutz A Coffin J E | 2004 | Cancer Biol Ther2004，3，12： | 1 |
| 6 | Optimization of an Extraction Procedure for the Quantification of Vitamin E in Tomato and Broccoli using Response Surface Methodology 显示文摘 | Junsoo Lee Lin Ye Landen W O | 2000 | Journal of Food Composition and Analysis2000，，13： | 1 |
| 7 | Serotonin transporter gene polymorphisms are associated with anxiety- related personality traits in women显示文摘 | MELKE J LANDEN M BAGHEI F | 2006 | American Journal of Medical Genetics2006，105，： | 1 |
| 8 | Insulin-like growth factor II in gynecological cancer: A preliminary study显示文摘 | Mathur SP Landen CP Datta SM | 2003 | Am J Reprocl Immunol2003，49，2： | 1 |
| 9 | Eph A2 as a target for ovarian cancer therapy 显示文摘 | Landen CN Kinch MS Sood AK | 2005 | Expert Opin Ther Targets2005，9，6： | 1 |
| 10 | Neuroendocrine modula- tion of signal transducer and activator of transcription-3 in ovarian cancer 显示文摘 | Landen CN Lin YG Pena GNA | 2007 | Cancer Res2007，67，10： | 1 |
| 11 | X-ray backlighting for the national ignition facility显示文摘 | Landen O L Farley D R Glendinning S G | 2001 | Rev Sci Instrum2001，72，1： | 1 |
| 12 | Expression of cyclooxy- genase-2 in cervical, endometrial, and ovarian malignancies 显示文摘 | Landen CN Jr Mathur SP Richardson MS | 2003 | Am J Obstet Gynecol2003，188，5： | 1 |
| 13 | Epigallocatechin gallate and sulforaphane combination treatment induce apoptosis in paclitaxelresistant ovarian cancer cells through hTERT and Bcl-2 down-regulation显示文摘 | Chen H Landen C N Li Y | 2013 | Exp Cell Res2013，319，5： | 1 |
| 14 | Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells显示文摘 | Halder J Landen C N Jr Lutgendorf S K | 2005 | Clin Cancer Res2005，11，24： | 1 |
| 15 | Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery显示文摘 | Chavez-Reyes A Bucana C | 2005 | Cancer Res2005，65，15： | 1 |
| 16 | Detailed measurements of a diffusive supersonic wave in a radiatively heated foam显示文摘 | Back C A Bauer J D Landen O L | 2000 | Phys Rev Lett2000，84，2： | 1 |
| 17 | Preoperative serum tissue factor levels are an independent prognostic factor in pa tients with ovarian carcinoma显示文摘 | Han LY Landen CN Jr Kamat AA | 2006 | J Clin Oncol2006，24，5： | 1 |
| 18 | Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer显示文摘 | Kamat AA Kim TJ Landen CN | 2007 | Cancer Res2007，67，1： | 1 |
| 19 | Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy显示文摘 | Halder J Kamat A A Landen C N Jr | 2006 | Clin Cancer Res2006，12，16： | 1 |
| 20 | Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer 显示文摘 | Kamat AA Kim TJ Landen CN | 2007 | Cancer Res2007，67，1： | 1 |
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