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| 1 | Ombitasvir/paritaprevir/ritonavir + dasabuvir +/-ribavirin in real world hepatitis C patients显示文摘BACKGROUND The hepatitis C virus(HCV) NS5A inhibitor ABT-267(ombitasvir, OBV), the HCV NS4/4A protease inhibitor ABT-450(paritaprevir, PTV), the CYP3A inhibitor ritonavir(r) and the non-nucleoside NS5B polymerase inhibitor ABT-333(dasabuvir, DSV)(OBV/PTV/r + DSV) with or without ribavirin(RBV) is a direct-acting antiviral regimen approved in the United States and other major countries for the treatment of HCV in genotype 1(GT1) infected patients. Patients with HCV who are considered 'hard-to-cure' have generally been excluded from registration trials due to rigorous study inclusion criteria, presence of comorbidities and previous treatment failures.AIM To investigate the efficacy of this regimen in HCV G1-infected patients historically excluded from clinical trials.METHODS Patients were ≥ 18 years old and chronically infected with HCV GT1(GT1a, GT1b or GT1a/1b). Patients were treatment-na?ve or previously failed a regimen including pegylated interferon/RBV +/-telaprevir, boceprevir, or simeprevir.One hundred patients were treated with the study drug regimen, which was administered for 12 or 24 wk +/-RBV according to GT1 subtype and presence/absence of cirrhosis. Patients were evaluated every 4 wk from treatment day 1 and at 4 and 12 wk after end-of-treatment.RESULTS Many of the patients studied had comorbidities(44.2% hypertensive, 33.7%obese, 20.2% cirrhotic) and 16% previously failed HCV treatment. Ninety-six patients completed study follow-up and 99% achieved 12-wk sustained virologic response. The majority(88.4%) of patients had undetectable HCV RNA by week 4. The most common adverse events were fatigue(12%), headache(10%),insomnia(9%) and diarrhea(8%); none led to treatment discontinuation. Physical and mental patient reported outcomes scores significantly improved after treatment. Almost all(98%) patients were treatment compliant.CONCLUSION In an all-comers HCV GT1 population, 12 or 24-wk of OBV/PTV/r + DSV +/-RBV is highly effective and tolerable and results in better mental and physical health following treatment. | Nicole Loo Eric Lawitz Naim Alkhouri Jennifer Wells Carmen Landaverde Angie Coste Rossalynn Salcido Michael Scott Fred Poordad | 2019 | World Journal of Gastroenterology2019，25，18： | 2 |
| 2 | Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccinederived poliovirus显示文摘 | Kew O Morris-Glasgow V Landaverde M | 2002 | Science2002，296，5566： | 1 |
| 3 | Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine- derived poliovirus 显示文摘 | Kew O Morris Glasgow V Landaverde M | 2002 | Science2002，296，5566： | 1 |
| 4 | Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine derived poliovirus显示文摘 | Kew OM Morris GV Landaverde M | 2002 | Science2002，296，5566： | 1 |
| 5 | Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccinederived poliovirus 显示文摘 | Kew OM Morris-Glasgow V Landaverde M | 2002 | Science2002，296，： | 1 |
| 6 | Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus 显示文摘 | Kew OM Morris-Glasgow V Landaverde M | 2002 | Science2002，296，5566： | 1 |
| 7 | Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccinederived poliovirus显示文摘 | Kew O Morris-Glasgow V Landaverde M | 2002 | Science2002，296，： | 1 |
| 8 | Outbreak of poli- omyelitis in Hispaniola associated with circulating type 1 vaccine- derived poliovirus 显示文摘 | Kew O Morris-Glasgow V Landaverde M | 2002 | Science2002，296，： | 1 |
| 9 | Outbreak of polio- myelitis in Hispaniola associated with circulating type 1 vaccine - derived poliovirus显示文摘 | Kew O Morris - Glasgow V Landaverde M | 2002 | Science2002，296，： | 1 |
| 10 | Outbreak of poli- omyelitis in Hispaniola associated with cirulating type 1 vaccine-de- rived poliovirus显示文摘 | Kew OM Morris-Glasgow V Landaverde M | 2002 | Science2002，296，56： | 1 |
| 11 | Outbreak of Poliomyelitis in Hispaniola Associated with Circulating Type Ⅰ Vaccine-derived Poliovirus显示文摘 | Olen Kew Victoria Morris-Glasgow Mauricio Landaverde | 2002 | Science2002，296，： | 1 |
| 12 | Fluid retention in cir rhosis pathophysiology and management显示文摘 | A Kashani C Landaverde V Medici | 2008 | Q J Med2008，101，71： | 1 |
| 13 | Outbreak of poliomyelitis in Hispaniola associated with circu lating type 1 vaccine-derived poliovirus显示文摘 | Kew O Morris-Glasgow V Landaverde M | 2002 | Science2002，296，5566： | 1 |
| 14 | Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus显示文摘 | Kew O Morris-Glasgow V Landaverde M | 2002 | Science2002，296，： | 1 |
| 15 | Outbreak of poliomye- litis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus 显示文摘 | Kew O Morris-Glasgow V Landaverde M Burns C Shaw J Garib Z Andr6 J Blackman E Freeman C J Jorba J Sutter R Tambini G Venczel L Pedreira C Laender F Shimizu H Yoneyama T Miyamura T van Der Avoort H Oberste M S Kilpatriek D Cochi S Pallansch M de Quadros C | 2002 | Science2002，296，5566： | 1 |
| 16 | Development of a disease-specific questionnaire to measure health-related quality of life in liver transplant recipients 显示文摘 | Saab S Ng V Landaverde C | 2011 | Liver Transpl2011，17，5： | 1 |
| 17 | Outbreak of Poliomyelitis in Hispaniola Associated with Circulating Type I Vaccine-derived Poliovirus显示文摘 | Glasgow V M Landaverde M | 2002 | Science2002，296，： | 1 |
| 18 | Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus显示文摘 | Kew OM Morris-Glasgow V Landaverde M | 2002 | Science2002，296，5566： | 1 |
| 19 | Patients With NASH and Cryptogenic Cirrhosis Are Less Likely Than Those With Hepatitis C to Receive Liver Transplants显示文摘 | Jacqueline G. O’Leary Carmen Landaverde Linda Jennings Robert M. Goldstein Gary L. Davis | 2011 | Clinical Gastroenterology and Hepatology2011，，8： | 1 |
| 20 | Outbreak of Poliomyelitis in Hispaniola Associated with Circulating Type I Vaccine-derived Poliovirus显示文摘 | Olen Kew Victoria Morris Glasgow Mauricio Landaverde | 2002 | Science2002，296，： | 1 |
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